Contemporary Epidemiology, Management, and In-Hospital Outcomes of Acute Myocarditis

Claire Bouleti; Theodora Bejan-Angoulvant; Clement Servoz; Ehmer Carsten; Thibaud Genet; Julien Ternacle; Jean-François Deux; Etienne Puymirat; Elie Mousseaux; Benjamin Alos; Rodrigue Garcia; Guillaume Bonnet; Alexis Jacquier; Benoit Lattuca; Olivier Huttin; Mariama Akodad; Alban Redheuil; Denis Angoulvant; Phalla Ou; Carsten Ehmer; Jérémie Abtan; Olivier Lairez; Pascal Lim; Victoria Tea; Guillaume Cayla; Cornelia Freitag; Laura Filippetti; Damien Mandry; Myriam Akodad; François Roubille; Gilles Barone-Rochette; Gerald Vanzetto; Adrien Jankowski; Adrian Mirolo; Christophe Tron; Eric Durand; Jean-Nicolas Dacher; Guillaume Taldir; Laurent Payot; Marine Jullien; Aymeric Menet; Alexandre Altes; Manuel Toledano; Guillaume Leurent; Christophe Thuaire; Marion Berous; Jean-Etienne Ricci; Houzefa Chopra; Nachwan Ghanem; Charly Udozen; Cyril Zakine; Yann Ancedy; Ariel Cohen; Gilles Lemesle; Nicolas Debry; François Pontana; Cyrille Boulogne; Victor Aboyans; Franck Haziza; Benjamin Honton; Emmanuelle Filippi; Mohammed Belkadi; Florent Le Ven; Martine Gilard; Antonin Trimaille; Patrick Ohlmann; Mickael Ohana; Loic Biere; Marc Sirol; Ludivine Eliahou; Julien Lenestour; Christophe Caussin; Christelle Diakov; Jean-François Paul; Bruno Vaquette; Philippe Pon-Bache-Gabrielsen; Agnes Charbonnel; Guillaume Clerfond; Benjamin Safar; Justine Enee; Vincent Probst; Jean-Michel Serfaty; Nicolas Rebotier; Julien Adjedj; Thomas Levasseur; Enrique Alonso; David Attias; Laurens Mitchell-Heggs; Patrick Dupouy; Nathan Mewton; François Bagate; Benoit Merat; MyocarditIRM Investigators

doi:10.1016/j.jchf.2025.03.038

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Contemporary Epidemiology, Management, and In-Hospital Outcomes of Acute Myocarditis

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Contemporary Epidemiology, Management, and In-Hospital Outcomes of Acute Myocarditis

Claire Bouleti, Theodora Bejan-Angoulvant, Clement Servoz, Ehmer Carsten, Thibaud Genet, Julien Ternacle, Jean-François Deux, Etienne Puymirat, Elie Mousseaux, Benjamin Alos, …

JACC. Heart failure, Vol.13(8), p.102492

08/2025

DOI: https://doi.org/10.1016/j.jchf.2025.03.038

Résumé

acute myocarditis

Cameroun

management

prognosis

Despite a frequently favorable evolution during the initial phase, acute myocarditis (AM) remains associated with heart failure and ventricular arrhythmia. There are no large prospective databases to provide robust results. The aim of this study was to describe baseline characteristics, real-life management, in-hospital outcomes, and determinants of prognosis in a large cohort of patients with AM admitted to cardiology, with a comparison of patients with and without initial severity criteria. MyocarditIRM (French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on [Magnetic Resonance Imaging] MRI) is a multicenter prospective observational study of patients with AM confirmed by cardiac magnetic resonance. Patients initially admitted to the intensive care unit or those who died before cardiac magnetic resonance–confirmed diagnosis were not included. In total, 803 consecutive hospitalized patients were enrolled at 49 participating centers between May 2016 and February 2019. The median age was 31 years (Q1-Q3: 23-41 years), and 82% were men. Chest pain was the most frequent symptom (93%), and 112 patients (14%) had severity criteria upon admission (left ventricular ejection fraction <50%, severe ventricular arrythmia, high-degree atrioventricular block, or cardiogenic shock). ST-segment elevation was observed in 49% of patients. Overall, 64 patients (8%) experienced in-hospital complications, defined as a composite of death; left ventricular ejection fraction ≤40%; sustained ventricular or supraventricular arrythmia; cardiogenic shock; and need for mechanical circulatory support, inotropic drugs, temporary cardiac pacing, pacemaker, or cardiac defibrillator implantation. Patients with severity criteria at admission were 10 times more likely to experience in-hospital complications. This prospective cohort represents the largest AM database worldwide. Although the recruitment process likely led to a selection of patients with lower risk AM, 8% experienced in-hospital complications, the major prognosis factor being severity criteria upon admission. (French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRI; NCT02717143) [Display omitted]

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Titre: Contemporary Epidemiology, Management, and In-Hospital Outcomes of Acute Myocarditis
Créateurs - sans rôle: Claire Bouleti - University of Poitiers, Clinical Investigation Center (INSERM 1402), Cardiology Department, Poitiers Hospital, Poitiers, France
Theodora Bejan-Angoulvant - Inserm
Clement Servoz - Cardiology Department, University Hospital of Toulouse, Toulouse, France
Ehmer Carsten - Radiology Department, Bichat University Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France
Thibaud Genet - Cardiology Department, University Hospital of Tours, Tours, France
Julien Ternacle - Cardiology Department, Mondor University Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France
Jean-François Deux - Radiology Department, Mondor University Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France
Etienne Puymirat - Assistance Publique – Hôpitaux de Paris
Elie Mousseaux - Radiology Department, European Hospital Georges Pompidou, Assistance Publique–Hôpitaux de Paris, INSERM PARCC, Université Paris-Cité, Paris, France
Benjamin Alos - University of Poitiers, Clinical Investigation Center (INSERM 1402), Cardiology Department, Poitiers Hospital, Poitiers, France
Rodrigue Garcia - University of Poitiers, Clinical Investigation Center (INSERM 1402), Cardiology Department, Poitiers Hospital, Poitiers, France
Guillaume Bonnet - Cardiology Department, University Hospital of Marseille, Assistance Publique–Hôpitaux de Marseille, Marseille, France
Alexis Jacquier - Radiology Department, University Hospital of Marseille, Assistance Publique–Hôpitaux de Marseille, Marseille, France
Benoit Lattuca - Cardiology Department, University Hospital of Nîmes, Nîmes, France
Olivier Huttin - Centre Hospitalier Régional et Universitaire de Nancy
Mariama Akodad - Cardiology Department, University Hospital of Montpellier, Montpellier, France
Alban Redheuil - Radiology Department, La Pitie-Salpétrière University Hospital, Assistance Publique–Hôpitaux de Paris, IHU ICAN, Paris, France
Denis Angoulvant - Cardiology Department, CHRU de Tours and UMR Inserm 1327 ISCHEMIA Membrane Signalling and Inflammation in Reperfusion Injuries, Tours University, Tours, France
Phalla Ou - Radiology Department, Bichat University Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France
Claire Bouleti - Bichat University Hospital, Paris, France
Phalla Ou - Bichat University Hospital, Paris, France
Carsten Ehmer - Bichat University Hospital, Paris, France
Jérémie Abtan - Bichat University Hospital, Paris, France
Olivier Lairez - Toulouse University Hospital, Rangueil, France
Clement Servoz - Toulouse University Hospital, Rangueil, France
Julien Ternacle - Henri Mondor University Hospital, Creteil, France
Pascal Lim - Henri Mondor University Hospital, Creteil, France
Jean-François Deux - Henri Mondor University Hospital, Creteil, France
Victoria Tea - HEGP University Hospital, Paris, France
Etienne Puymirat - HEGP University Hospital, Paris, France
Elie Mousseaux - HEGP University Hospital, Paris, France
Rodrigue Garcia - Poitiers University Hospital, Poitiers, France
Benjamin Alos - Poitiers University Hospital, Poitiers, France
Guillaume Bonnet - Marseille University Hospital, Marseille, France
Alexis Jacquier - Marseille University Hospital, Marseille, France
Benoit Lattuca - Nîmes University Hospital, Nîmes, France
Guillaume Cayla - Nîmes University Hospital, Nîmes, France
Cornelia Freitag - Nîmes University Hospital, Nîmes, France
Olivier Huttin - Centre Hospitalier Régional et Universitaire de Nancy
Laura Filippetti - Nancy University Hospital, Vandoeuvre-les-Nancy, France
Damien Mandry - Nancy University Hospital, Vandoeuvre-les-Nancy, France
Myriam Akodad - Montpellier University Hospital, Montpellier, France
François Roubille - Montpellier University Hospital, Montpellier, France
Gilles Barone-Rochette - Grenoble University Hospital, Echirolles, France
Gerald Vanzetto - Grenoble University Hospital, Echirolles, France
Adrien Jankowski - Grenoble University Hospital, Echirolles, France
Adrian Mirolo - Charles Nicolle University Hospital, Rouen, France
Christophe Tron - Charles Nicolle University Hospital, Rouen, France
Eric Durand - Charles Nicolle University Hospital, Rouen, France
Jean-Nicolas Dacher - Charles Nicolle University Hospital, Rouen, France
Guillaume Taldir - Saint-Brieuc Hospital, Saint-Brieuc, France
Laurent Payot - Saint-Brieuc Hospital, Saint-Brieuc, France
Marine Jullien - Jacques Cartier Institute, Massy, France
Benjamin Alos - Jacques Cartier Institute, Massy, France
Aymeric Menet - Catholic University of Lille, Lomme, France
Alexandre Altes - Catholic University of Lille, Lomme, France
Manuel Toledano - Catholic University of Lille, Lomme, France
Guillaume Leurent - Pontchaillou University Hospital, Rennes, France
Christophe Thuaire - Chartres Hospital, Le Coudray, France
Marion Berous - Le Millenaire Clinic, Montpellier, France
Jean-Etienne Ricci - Le Millenaire Clinic, Montpellier, France
Houzefa Chopra - Simone Veil Hospital, Eaubonne, France
Nachwan Ghanem - Simone Veil Hospital, Eaubonne, France
Charly Udozen - Simone Veil Hospital, Eaubonne, France
Cyril Zakine - Jossigny Hospital, Jossigny, France
Yann Ancedy - Saint-Antoine Hospital, Paris, France
Ariel Cohen - Saint-Antoine Hospital, Paris, France
Gilles Lemesle - Lille University Hospital, Lille, France
Nicolas Debry - Lille University Hospital, Lille, France
François Pontana - Lille University Hospital, Lille, France
Cyrille Boulogne - Limoges University Hospital, Limoges, France
Victor Aboyans - Limoges University Hospital, Limoges, France
Franck Haziza - Foch Hospital, Suresnes, France
Benjamin Honton - Pasteur Clinic, Toulouse, France
Emmanuelle Filippi - Vannes Hospital, Vannes, France
Mohammed Belkadi - Vannes Hospital, Vannes, France
Florent Le Ven - Brest University Hospital, Brest, France
Martine Gilard - Brest University Hospital, Brest, France
Antonin Trimaille - Hôpitaux Universitaires de Strasbourg
Patrick Ohlmann - Hôpitaux Universitaires de Strasbourg
Mickael Ohana - Hôpitaux Universitaires de Strasbourg
Loic Biere - Angers University Hospital, Angers, France
Marc Sirol - Ambroise Paré University Hospital, Boulogne, France
Benjamin Alos - Ambroise Paré University Hospital, Boulogne, France
Ludivine Eliahou - Beclere University Hospital, Clamart, France
Julien Lenestour - La Rochelle Hospital, La Rochelle, France
Christophe Caussin - Institut Mutualiste Montsouris, Paris, France
Christelle Diakov - Institut Mutualiste Montsouris, Paris, France
Jean-François Paul - Institut Mutualiste Montsouris, Paris, France
Bruno Vaquette - Bois Bernard Hospital, Bois-Bernard, France
Philippe Pon-Bache-Gabrielsen - Cherbourg Hospital, Cherbourg, France
Agnes Charbonnel - Begin Military Hospital, Percy, France
Guillaume Clerfond - Clermont-Ferrand University Hospital, Clermont-Ferrand, France
Benjamin Safar - Montfermeil Hospital, Montfermeil, France
Justine Enee - Nantes University Hospital, Nantes, France
Vincent Probst - Nantes University Hospital, Nantes, France
Jean-Michel Serfaty - Nantes University Hospital, Nantes, France
Nicolas Rebotier - Orleans Hospital, Orleans, France
Julien Adjedj - Cochin University Hospital, Paris, France
Thomas Levasseur - Reims University Hospital, Reims, France
Enrique Alonso - Clinique des Fontaines, Melun, France
David Attias - Centre Cardiologique du Nord, Saint-Denis, France
Laurens Mitchell-Heggs - Centre Cardiologique du Nord, Saint-Denis, France
Patrick Dupouy - Antony Hospital, Antony, France
Nathan Mewton - Louis Pradel University Hospital, Bron (Lyon), France
François Bagate - Ambroise Paré Clinic, Neuilly, France
Benoit Merat - Lariboisière University Hospital, Paris, France
Cyrille Boulogne - Tulle Hospital, Tulle, France
MyocarditIRM Investigators
Détails de publication: JACC. Heart failure, Vol.13(8), p.102492
Éditeur: Elsevier Inc
Identifiants: 99139723409311
Unité académique: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp; Recherche hors université; Initial MAnagement & prevent of acute orGan failures IN critically ill patiEnts - IMAGINE
Langue: English
Type de ressource: Journal article