Comprehensive molecular profiling of lung adenocarcinoma

Eric A. Collisson; Joshua D. Campbell; Angela N. Brooks; Alice H. Berger; William Lee; Juliann Chmielecki; David G. Beer; Leslie Cope; Chad J. Creighton; Ludmila Danilova; Li Ding; Gad Getz; Peter S. Hammerman; D. Neil Hayes; Bryan Hernandez; James G. Herman; John V. Heymach; Igor Jurisica; Raju Kucherlapati; David Kwiatkowski; Marc Ladanyi; Gordon Robertson; Nikolaus Schultz; Ronglai Shen; Rileen Sinha; Carrie Sougnez; Ming-Sound Tsao; William D. Travis; John N. Weinstein; Dennis A. Wigle; Matthew D. Wilkerson; Andy Chu; Andrew D. Cherniack; Angela Hadjipanayis; Mara Rosenberg; Daniel J. Weisenberger; Peter W. Laird; Amie Radenbaugh; Singer Ma; Joshua M. Stuart; Lauren Averett Byers; Stephen B. Baylin; Ramaswamy Govindan; Matthew Meyerson; Stacey B. Gabriel; Kristian Cibulskis; Jaegil Kim; Chip Stewart; Lee Lichtenstein; Eric S. Lander; Michael S. Lawrence; Getz; Cyriac Kandoth; Robert Fulton; Lucinda L. Fulton; Michael D. McLellan; Richard K. Wilson; Kai Ye; Catrina C. Fronick; Christopher A. Maher; Christopher A. Miller; Michael C. Wendl; Christopher Cabanski; Elaine Mardis; David Wheeler; Miruna Balasundaram; Yaron S. N. Butterfield; Rebecca Carlsen; Eric Chuah; Noreen Dhalla; Ranabir Guin; Carrie Hirst; Darlene Lee; Haiyan I. Li; Michael Mayo; Richard A. Moore; Andrew J. Mungall; Jacqueline E. Schein; Payal Sipahimalani; Angela Tam; Richard Varhol; A. Gordon Robertson; Natasja Wye; Nina Thiessen; Robert A. Holt; Steven J. M. Jones; Marco A. Marra; Marcin Imielinski; Robert C. Onofrio; Eran Hodis; Travis Zack; Elena Helman; Chandra Sekhar Pedamallu; Jill Mesirov; Gordon Saksena; Steven E. Schumacher; Scott L. Carter; Levi Garraway; Rameen Beroukhim; Semin Lee; Harshad S. Mahadeshwar; Angeliki Pantazi; Alexei Protopopov; Xiaojia Ren; Sahil Seth; Xingzhi Song; Jiabin Tang; Lixing Yang; Jianhua Zhang; Peng-Chieh Chen; Michael Parfenov; Andrew Wei Xu; Netty Santoso; Lynda Chin; Peter J. Park; Katherine A. Hoadley; J. Todd Auman; Shaowu Meng; Yan Shi; Elizabeth Buda; Scot Waring; Umadevi Veluvolu; Donghui Tan; Piotr A. Mieczkowski; Corbin D. Jones; Janae V. Simons; Matthew G. Soloway; Tom Bodenheimer; Stuart R. Jefferys; Jeffrey Roach; Alan P. Hoyle; Junyuan Wu; Saianand Balu; Darshan Singh; Jan F. Prins; J. S. Marron; Joel S. Parker; Charles M. Perou; Jinze Liu; Dennis T. Maglinte; Philip H. Lai; Moiz S. Bootwalla; David J. Van Den Berg; Timothy Triche; Juok Cho; Daniel DiCara; David Heiman; Pei Lin; William Mallard; Douglas Voet; Hailei Zhang; Lihua Zou; Michael S. Noble; Nils Gehlenborg; Helga Thorvaldsdottir; Marc-Danie Nazaire; Jim Robinson; B. Arman Aksoy; Giovanni Ciriello; Barry S. Taylor; Gideon Dresdner; Jianjiong Gao; Benjamin Gross; Venkatraman E. Seshan; Boris Reva; S. Onur Sumer; Nils Weinhold; Chris Sander; Sam Ng; Jingchun Zhu; Christopher C. Benz; Christina Yau; David Haussler; Paul T. Spellman; Patrick K. Kimes; Bradley M. Broom; Jing Wang; Yiling Lu; Patrick Kwok Shing Ng; Lixia Diao; Wenbin Liu; Christopher I. Amos; Rehan Akbani; Gordon B. Mills; Erin Curley; Joseph Paulauskis; Kevin Lau; Scott Morris; Troy Shelton; David Mallery; Johanna Gardner; Robert Penny; Charles Saller; Katherine Tarvin; William G. Richards; Robert Cerfolio; Ayesha Bryant; Daniel P. Raymond; Nathan A. Pennell; Carol Farver; Christine Czerwinski; Lori Huelsenbeck-Dill; Mary Iacocca; Nicholas Petrelli; Brenda Rabeno; Jennifer Brown; Thomas Bauer; Oleg Dolzhanskiy; Olga Potapova; Daniil Rotin; Olga Voronina; Elena Nemirovich-Danchenko; Konstantin V. Fedosenko; Anthony Gal; Madhusmita Behera; Suresh S. Ramalingam; Gabriel Sica; Douglas Flieder; Jeff Boyd; JoEllen Weaver; Bernard Kohl; Dang Huy Quoc Thinh; George Sandusky; Hartmut Juhl; Edwina Duhig; Peter Illei; Edward Gabrielson; James Shin; Beverly Lee; Kristen Rogers; Dante Trusty; Malcolm V. Brock; Christina Williamson; Eric Burks; Kimberly Rieger-Christ; Antonia Holway; Travis Sullivan; Michael K. Asiedu; Farhad Kosari; Natasha Rekhtman; Maureen Zakowski; Valerie W. Rusch; Paul Zippile; James Suh; Harvey Pass; Chandra Goparaju; Yvonne Owusu-Sarpong; John M. S. Bartlett; Sugy Kodeeswaran; Jeremy Parfitt; Harmanjatinder Sekhon; Monique Albert; John Eckman; Jerome B. Myers; Richard Cheney; Carl Morrison; Carmelo Gaudioso; Jeffrey A. Borgia; Philip Bonomi; Mark Pool; Michael J. Liptay; Fedor Moiseenko; Irina Zaytseva; Hendrik Dienemann; Michael Meister; Philipp A. Schnabel; Thomas R. Muley; Martin Peifer; Carmen Gomez-Fernandez; Lynn Herbert; Sophie Egea; Mei Huang; Leigh B. Thorne; Lori Boice; Ashley Hill Salazar; William K. Funkhouser; W. Kimryn Rathmell; Rajiv Dhir; Samuel A. Yousem; Sanja Dacic; Frank Schneider; Jill M. Siegfried; Richard Hajek; Mark A. Watson; Sandra McDonald; Bryan Meyers; Belinda Clarke; Ian A. Yang; Kwun M. Fong; Lindy Hunter; Morgan Windsor; Rayleen V. Bowman; Solange Peters; Igor Letovanec; Khurram Z. Khan; Mark A. Jensen; Eric E. Snyder; Deepak Srinivasan; Ari B. Kahn; Julien Baboud; David A. Pot; Kenna R. Mills Shaw; Margi Sheth; Tanja Davidsen; John A. Demchok; Liming Yang; Zhining Wang; Roy Tarnuzzer; Jean Claude Zenklusen; Bradley A. Ozenberger; Heidi J. Sofia; Canc Genome Atlas Res Network

doi:10.1038/nature13385

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Comprehensive molecular profiling of lung adenocarcinoma

Article de revue

Avec comité de lecture

Comprehensive molecular profiling of lung adenocarcinoma

Eric A. Collisson, Joshua D. Campbell, Angela N. Brooks, Alice H. Berger, William Lee, Juliann Chmielecki, David G. Beer, Leslie Cope, Chad J. Creighton, Ludmila Danilova, …

Nature (London), Vol.511(7511), pp.543-550

31/07/2014

DOI: https://doi.org/10.1038/nature13385

PMID: 25079552

Résumé

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen(mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis.

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Titre: Comprehensive molecular profiling of lung adenocarcinoma
Créateurs - sans rôle: Eric A. Collisson - Univ Calif San Francisco, San Francisco, CA 94158 USA
Joshua D. Campbell
Angela N. Brooks - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Alice H. Berger
William Lee - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Juliann Chmielecki
David G. Beer - Univ Michigan, Ann Arbor, MI 48109 USA
Leslie Cope - Johns Hopkins Univ, Baltimore, MD 21287 USA
Chad J. Creighton - Baylor Coll Med, Houston, TX 77030 USA
Ludmila Danilova - Johns Hopkins Univ, Baltimore, MD 21287 USA
Li Ding - Washington Univ, St Louis, MO 63108 USA
Gad Getz - Massachusetts Gen Hosp, Boston, MA 02114 USA
Peter S. Hammerman
D. Neil Hayes - Univ N Carolina, Chapel Hill, NC 27599 USA
Bryan Hernandez
James G. Herman - Johns Hopkins Univ, Baltimore, MD 21287 USA
John V. Heymach - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Igor Jurisica - Princess Margaret Canc Ctr, Toronto, ON M5G 2M9, Canada
Raju Kucherlapati - Harvard Univ, Sch Med, Boston, MA 02115 USA
David Kwiatkowski - Brigham & Womens Hosp, Boston, MA 02115 USA
Marc Ladanyi - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Gordon Robertson - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Nikolaus Schultz - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Ronglai Shen - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Rileen Sinha - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Carrie Sougnez
Ming-Sound Tsao - Princess Margaret Canc Ctr, Toronto, ON M5G 2M9, Canada
William D. Travis - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
John N. Weinstein - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Dennis A. Wigle - Mayo Clin, Rochester, MN 55905 USA
Matthew D. Wilkerson - Univ N Carolina, Chapel Hill, NC 27599 USA
Andy Chu - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Andrew D. Cherniack
Angela Hadjipanayis - Harvard Univ, Sch Med, Boston, MA 02115 USA
Mara Rosenberg
Daniel J. Weisenberger - Univ So Calif, Los Angeles, CA 90033 USA
Peter W. Laird - Univ So Calif, Los Angeles, CA 90033 USA
Amie Radenbaugh - Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA
Singer Ma - Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA
Joshua M. Stuart - Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA
Lauren Averett Byers - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Stephen B. Baylin - Johns Hopkins Univ, Baltimore, MD 21287 USA
Ramaswamy Govindan - Washington Univ, St Louis, MO 63108 USA
Matthew Meyerson
Mara Rosenberg
Stacey B. Gabriel
Kristian Cibulskis
Carrie Sougnez
Jaegil Kim
Chip Stewart
Lee Lichtenstein
Eric S. Lander - MIT, Cambridge, MA 02142 USA
Michael S. Lawrence
Getz - Harvard Univ, Sch Med, Boston, MA 02115 USA
Cyriac Kandoth - Washington Univ, St Louis, MO 63108 USA
Robert Fulton - Washington Univ, St Louis, MO 63108 USA
Lucinda L. Fulton - Washington Univ, St Louis, MO 63108 USA
Michael D. McLellan - Washington Univ, St Louis, MO 63108 USA
Richard K. Wilson - Washington Univ, St Louis, MO 63108 USA
Kai Ye - Washington Univ, St Louis, MO 63108 USA
Catrina C. Fronick - Washington Univ, St Louis, MO 63108 USA
Christopher A. Maher - Washington Univ, St Louis, MO 63108 USA
Christopher A. Miller - Washington Univ, St Louis, MO 63108 USA
Michael C. Wendl - Washington Univ, St Louis, MO 63108 USA
Christopher Cabanski - Washington Univ, St Louis, MO 63108 USA
Li Ding
Elaine Mardis - Washington Univ, St Louis, MO 63108 USA
Ramaswamy Govindan
Chad J. Creighton
David Wheeler - Baylor Coll Med, Houston, TX 77030 USA
Miruna Balasundaram - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Yaron S. N. Butterfield - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Rebecca Carlsen - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Andy Chu
Eric Chuah - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Noreen Dhalla - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Ranabir Guin - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Carrie Hirst - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Darlene Lee - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Haiyan I. Li - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Michael Mayo - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Richard A. Moore - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Andrew J. Mungall - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Jacqueline E. Schein - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Payal Sipahimalani - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Angela Tam - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Richard Varhol - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
A. Gordon Robertson - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Natasja Wye - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Nina Thiessen - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Robert A. Holt - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Steven J. M. Jones - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Marco A. Marra - BC Canc Agcy, Vancouver, BC V5Z 4S6, Canada
Joshua D. Campbell
Angela N. Brooks
Juliann Chmielecki
Marcin Imielinski - Harvard Univ, Sch Med, Boston, MA 02115 USA
Robert C. Onofrio
Eran Hodis - Harvard Univ, Sch Med, Boston, MA 02115 USA
Travis Zack
Carrie Sougnez
Elena Helman
Chandra Sekhar Pedamallu
Jill Mesirov
Andrew D. Cherniack
Gordon Saksena
Steven E. Schumacher
Scott L. Carter
Bryan Hernandez
Levi Garraway - Dana Farber Canc Inst, Boston, MA 02115 USA
Rameen Beroukhim - Dana Farber Canc Inst, Boston, MA 02115 USA
Stacey B. Gabriel
Gad Getz
Matthew Meyerson - Dana Farber Canc Inst, Boston, MA 02115 USA
Angela Hadjipanayis - Harvard Univ, Sch Med, Boston, MA 02115 USA
Semin Lee - Harvard Univ, Sch Med, Boston, MA 02115 USA
Harshad S. Mahadeshwar - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Angeliki Pantazi - Harvard Univ, Sch Med, Boston, MA 02115 USA
Alexei Protopopov - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Xiaojia Ren - Harvard Univ, Sch Med, Boston, MA 02115 USA
Sahil Seth - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Xingzhi Song - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Jiabin Tang - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Lixing Yang - Harvard Univ, Sch Med, Boston, MA 02115 USA
Jianhua Zhang - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Peng-Chieh Chen - Harvard Univ, Sch Med, Boston, MA 02115 USA
Michael Parfenov - Harvard Univ, Sch Med, Boston, MA 02115 USA
Andrew Wei Xu - Harvard Univ, Sch Med, Boston, MA 02115 USA
Netty Santoso - Harvard Univ, Sch Med, Boston, MA 02115 USA
Lynda Chin - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Peter J. Park - Harvard University
Raju Kucherlapati - Harvard Univ, Sch Med, Boston, MA 02115 USA
Katherine A. Hoadley - Univ N Carolina, Chapel Hill, NC 27599 USA
J. Todd Auman - Univ N Carolina, Chapel Hill, NC 27599 USA
Shaowu Meng - Univ N Carolina, Chapel Hill, NC 27599 USA
Yan Shi - Univ N Carolina, Chapel Hill, NC 27599 USA
Elizabeth Buda - Univ N Carolina, Chapel Hill, NC 27599 USA
Scot Waring - Univ N Carolina, Chapel Hill, NC 27599 USA
Umadevi Veluvolu - Univ N Carolina, Chapel Hill, NC 27599 USA
Donghui Tan - Univ N Carolina, Chapel Hill, NC 27599 USA
Piotr A. Mieczkowski - Univ N Carolina, Chapel Hill, NC 27599 USA
Corbin D. Jones - Univ N Carolina, Chapel Hill, NC 27599 USA
Janae V. Simons - Univ N Carolina, Chapel Hill, NC 27599 USA
Matthew G. Soloway - Univ N Carolina, Chapel Hill, NC 27599 USA
Tom Bodenheimer - Univ N Carolina, Chapel Hill, NC 27599 USA
Stuart R. Jefferys - Univ N Carolina, Chapel Hill, NC 27599 USA
Jeffrey Roach - Univ N Carolina, Chapel Hill, NC 27599 USA
Alan P. Hoyle - Univ N Carolina, Chapel Hill, NC 27599 USA
Junyuan Wu - Univ N Carolina, Chapel Hill, NC 27599 USA
Saianand Balu - Univ N Carolina, Chapel Hill, NC 27599 USA
Darshan Singh - Univ N Carolina, Chapel Hill, NC 27599 USA
Jan F. Prins - Univ N Carolina, Chapel Hill, NC 27599 USA
J. S. Marron - Univ N Carolina, Chapel Hill, NC 27599 USA
Joel S. Parker - Univ N Carolina, Chapel Hill, NC 27599 USA
D. Neil Hayes
Charles M. Perou - Univ N Carolina, Chapel Hill, NC 27599 USA
Jinze Liu - Univ Kentucky, Lexington, KY 40515 USA
Leslie Cope
Ludmila Danilova
Daniel J. Weisenberger
Dennis T. Maglinte - Univ So Calif, Los Angeles, CA 90033 USA
Philip H. Lai - Univ So Calif, Los Angeles, CA 90033 USA
Moiz S. Bootwalla - Univ So Calif, Los Angeles, CA 90033 USA
David J. Van Den Berg - Univ So Calif, Los Angeles, CA 90033 USA
Timothy Triche - Univ So Calif, Los Angeles, CA 90033 USA
Stephen B. Baylin
Peter W. Laird
Mara Rosenberg
Lynda Chin
Jianhua Zhang
Juok Cho
Daniel DiCara
David Heiman
Pei Lin
William Mallard
Douglas Voet
Hailei Zhang
Lihua Zou
Michael S. Noble
Michael S. Lawrence
Gordon Saksena
Nils Gehlenborg
Helga Thorvaldsdottir
Jill Mesirov
Marc-Danie Nazaire
Jim Robinson
Gad Getz
William Lee
B. Arman Aksoy - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Giovanni Ciriello - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Barry S. Taylor - Univ Calif San Francisco, San Francisco, CA 94158 USA
Gideon Dresdner - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Jianjiong Gao - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Benjamin Gross - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Venkatraman E. Seshan - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Marc Ladanyi
Boris Reva - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Rileen Sinha - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
S. Onur Sumer - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Nils Weinhold - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Nikolaus Schultz - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Ronglai Shen
Chris Sander - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Sam Ng - Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA
Singer Ma
Jingchun Zhu - Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA
Amie Radenbaugh - Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA
Joshua M. Stuart
Christopher C. Benz - Buck Inst Age Res, Novato, CA 94945 USA
Christina Yau - Buck Inst Age Res, Novato, CA 94945 USA
David Haussler - Univ Calif Santa Cruz, Santa Cruz, CA 95064 USA
Paul T. Spellman - Oregon Hlth & Sci Univ, Portland, OR 97239 USA
Matthew D. Wilkerson
Joel S. Parker
Katherine A. Hoadley
Patrick K. Kimes - Univ N Carolina, Chapel Hill, NC 27599 USA
D. Neil Hayes
Charles M. Perou
Bradley M. Broom - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Jing Wang - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Yiling Lu - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Patrick Kwok Shing Ng - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Lixia Diao - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Lauren Averett Byers
Wenbin Liu - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
John V. Heymach
Christopher I. Amos - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
John N. Weinstein
Rehan Akbani - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Gordon B. Mills - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Erin Curley - Int Genom Consortium, Phoenix, AZ 85004 USA
Joseph Paulauskis - Int Genom Consortium, Phoenix, AZ 85004 USA
Kevin Lau - Int Genom Consortium, Phoenix, AZ 85004 USA
Scott Morris - Int Genom Consortium, Phoenix, AZ 85004 USA
Troy Shelton - Int Genom Consortium, Phoenix, AZ 85004 USA
David Mallery - Int Genom Consortium, Phoenix, AZ 85004 USA
Johanna Gardner - Int Genom Consortium, Phoenix, AZ 85004 USA
Robert Penny - Int Genom Consortium, Phoenix, AZ 85004 USA
Charles Saller - Analyt Biol Serv Inc, Wilmington, DE 19801 USA
Katherine Tarvin - Analyt Biol Serv Inc, Wilmington, DE 19801 USA
William G. Richards - Brigham & Womens Hosp, Boston, MA 02115 USA
Robert Cerfolio - Univ Alabama Birmingham, Birmingham, AL 35294 USA
Ayesha Bryant - Univ Alabama Birmingham, Birmingham, AL 35294 USA
Daniel P. Raymond - Cleveland Clin, Cleveland, OH 44195 USA
Nathan A. Pennell - Cleveland Clin, Cleveland, OH 44195 USA
Carol Farver - Cleveland Clin, Cleveland, OH 44195 USA
Christine Czerwinski - Christiana Care, Newark, DE 19713 USA
Lori Huelsenbeck-Dill - Christiana Care, Newark, DE 19713 USA
Mary Iacocca - Christiana Care, Newark, DE 19713 USA
Nicholas Petrelli - Christiana Care, Newark, DE 19713 USA
Brenda Rabeno - Christiana Care, Newark, DE 19713 USA
Jennifer Brown - Christiana Care, Newark, DE 19713 USA
Thomas Bauer - Christiana Care, Newark, DE 19713 USA
Oleg Dolzhanskiy - Cureline Inc, San Francisco, CA 94080 USA
Olga Potapova - Cureline Inc, San Francisco, CA 94080 USA
Daniil Rotin - Cureline Inc, San Francisco, CA 94080 USA
Olga Voronina - Cureline Inc, San Francisco, CA 94080 USA
Elena Nemirovich-Danchenko - Cureline Inc, San Francisco, CA 94080 USA
Konstantin V. Fedosenko - Cureline Inc, San Francisco, CA 94080 USA
Anthony Gal - Emory Univ, Atlanta, GA 30322 USA
Madhusmita Behera - Emory Univ, Atlanta, GA 30322 USA
Suresh S. Ramalingam - Emory Univ, Atlanta, GA 30322 USA
Gabriel Sica - Emory Univ, Atlanta, GA 30322 USA
Douglas Flieder - Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
Jeff Boyd - Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
JoEllen Weaver - Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
Bernard Kohl - ILSbio, Chestertown, MD 21620 USA
Dang Huy Quoc Thinh - ILSbio, Chestertown, MD 21620 USA
George Sandusky - Indiana Univ Sch Med, Indianapolis, IN 46202 USA
Hartmut Juhl - Individumed, Silver Spring, MD 20910 USA
Edwina Duhig - Prince Charles Hosp, Brisbane, Qld 4032, Australia
Peter Illei - Johns Hopkins Univ, Baltimore, MD 21287 USA
Edward Gabrielson - Johns Hopkins Univ, Baltimore, MD 21287 USA
James Shin - Johns Hopkins Univ, Baltimore, MD 21287 USA
Beverly Lee - Johns Hopkins Univ, Baltimore, MD 21287 USA
Kristen Rogers - Johns Hopkins Univ, Baltimore, MD 21287 USA
Dante Trusty - Johns Hopkins Univ, Baltimore, MD 21287 USA
Malcolm V. Brock - Johns Hopkins Univ, Baltimore, MD 21287 USA
Christina Williamson - Lahey Hosp & Med Ctr, Burlington, MA 01805 USA
Eric Burks - Lahey Hosp & Med Ctr, Burlington, MA 01805 USA
Kimberly Rieger-Christ - Lahey Hosp & Med Ctr, Burlington, MA 01805 USA
Antonia Holway - Lahey Hosp & Med Ctr, Burlington, MA 01805 USA
Travis Sullivan - Lahey Hosp & Med Ctr, Burlington, MA 01805 USA
Dennis A. Wigle
Michael K. Asiedu - Mayo Clin, Rochester, MN 55905 USA
Farhad Kosari - Mayo Clin, Rochester, MN 55905 USA
William D. Travis
Natasha Rekhtman - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Maureen Zakowski - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Valerie W. Rusch - Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA
Paul Zippile - NYU Langone Med Ctr, New York, NY 10016 USA
James Suh - NYU Langone Med Ctr, New York, NY 10016 USA
Harvey Pass - NYU Langone Med Ctr, New York, NY 10016 USA
Chandra Goparaju - NYU Langone Med Ctr, New York, NY 10016 USA
Yvonne Owusu-Sarpong - NYU Langone Med Ctr, New York, NY 10016 USA
John M. S. Bartlett - Ontario Inst Canc Res, Ontario Tumour Bank, Toronto, ON M5G 0A3, Canada
Sugy Kodeeswaran - Ontario Inst Canc Res, Ontario Tumour Bank, Toronto, ON M5G 0A3, Canada
Jeremy Parfitt - Ontario Inst Canc Res, Ontario Tumour Bank, Toronto, ON M5G 0A3, Canada
Harmanjatinder Sekhon - Ontario Inst Canc Res, Ontario Tumour Bank, Toronto, ON M5G 0A3, Canada
Monique Albert - Ontario Inst Canc Res, Ontario Tumour Bank, Toronto, ON M5G 0A3, Canada
John Eckman - Penrose St Francis Hlth Serv, Colorado Springs, CO 80907 USA
Jerome B. Myers - Penrose St Francis Hlth Serv, Colorado Springs, CO 80907 USA
Richard Cheney - Roswel Pk Canc Ctr, Buffalo, NY 14263 USA
Carl Morrison - Roswel Pk Canc Ctr, Buffalo, NY 14263 USA
Carmelo Gaudioso - Roswel Pk Canc Ctr, Buffalo, NY 14263 USA
Jeffrey A. Borgia - Rush Univ, Med Ctr, Chicago, IL 60612 USA
Philip Bonomi - Rush Univ, Med Ctr, Chicago, IL 60612 USA
Mark Pool - Rush Univ, Med Ctr, Chicago, IL 60612 USA
Michael J. Liptay - Rush Univ, Med Ctr, Chicago, IL 60612 USA
Fedor Moiseenko - St Petersburg Acad Univ, St Petersburg 199034, Russia
Irina Zaytseva - St Petersburg Acad Univ, St Petersburg 199034, Russia
Hendrik Dienemann - Univ Klinikum Heidelberg, Thoraxklin, D-69126 Heidelberg, Germany
Michael Meister - Univ Klinikum Heidelberg, Thoraxklin, D-69126 Heidelberg, Germany
Philipp A. Schnabel - Heidelberg Univ, D-69120 Heidelberg, Germany
Thomas R. Muley - Univ Klinikum Heidelberg, Thoraxklin, D-69126 Heidelberg, Germany
Martin Peifer - Univ Cologne, D-50931 Cologne, Germany
Carmen Gomez-Fernandez - Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA
Lynn Herbert - Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA
Sophie Egea - Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA
Mei Huang - Univ N Carolina, Chapel Hill, NC 27599 USA
Leigh B. Thorne - Univ N Carolina, Chapel Hill, NC 27599 USA
Lori Boice - Univ N Carolina, Chapel Hill, NC 27599 USA
Ashley Hill Salazar - Univ N Carolina, Chapel Hill, NC 27599 USA
William K. Funkhouser - Univ N Carolina, Chapel Hill, NC 27599 USA
W. Kimryn Rathmell - Univ N Carolina, Chapel Hill, NC 27599 USA
Rajiv Dhir - Univ Pittsburgh, Pittsburgh, PA 15213 USA
Samuel A. Yousem - Univ Pittsburgh, Pittsburgh, PA 15213 USA
Sanja Dacic - Univ Pittsburgh, Pittsburgh, PA 15213 USA
Frank Schneider - Univ Pittsburgh, Pittsburgh, PA 15213 USA
Jill M. Siegfried - Univ Pittsburgh, Pittsburgh, PA 15213 USA
Richard Hajek - Univ Texas MD Anderson Canc Ctr, Houston, TX 77054 USA
Mark A. Watson - Washington Univ, St Louis, MO 63108 USA
Sandra McDonald - Washington Univ, St Louis, MO 63108 USA
Bryan Meyers - Washington Univ, St Louis, MO 63108 USA
Belinda Clarke - Prince Charles Hosp, Brisbane, Qld 4032, Australia
Ian A. Yang - Prince Charles Hosp, Brisbane, Qld 4032, Australia
Kwun M. Fong - Prince Charles Hosp, Brisbane, Qld 4032, Australia
Lindy Hunter - Prince Charles Hosp, Brisbane, Qld 4032, Australia
Morgan Windsor - Prince Charles Hosp, Brisbane, Qld 4032, Australia
Rayleen V. Bowman - Prince Charles Hosp, Brisbane, Qld 4032, Australia
Solange Peters - CHU Vaudois, Lausanne & European Thorac Oncol Platform, CH-1011 Lausanne, Switzerland
Igor Letovanec - CHU Vaudois, Lausanne & European Thorac Oncol Platform, CH-1011 Lausanne, Switzerland
Khurram Z. Khan - Ziauddin Univ Hosp, Karachi 75300, Pakistan
Mark A. Jensen - SRA Int Inc, Fairfax, VA 22033 USA
Eric E. Snyder - SRA Int Inc, Fairfax, VA 22033 USA
Deepak Srinivasan - SRA Int Inc, Fairfax, VA 22033 USA
Ari B. Kahn - SRA Int Inc, Fairfax, VA 22033 USA
Julien Baboud - SRA Int Inc, Fairfax, VA 22033 USA
David A. Pot - SRA Int Inc, Fairfax, VA 22033 USA
Kenna R. Mills Shaw - NCI, NIH, Bethesda, MD 20892 USA
Margi Sheth - NCI, NIH, Bethesda, MD 20892 USA
Tanja Davidsen - NCI, NIH, Bethesda, MD 20892 USA
John A. Demchok - NCI, NIH, Bethesda, MD 20892 USA
Liming Yang - NCI, NIH, Bethesda, MD 20892 USA
Zhining Wang - NCI, NIH, Bethesda, MD 20892 USA
Roy Tarnuzzer - NCI, NIH, Bethesda, MD 20892 USA
Jean Claude Zenklusen - NCI, NIH, Bethesda, MD 20892 USA
Bradley A. Ozenberger - NHGRI, NIH, Bethesda, MD 20892 USA
Heidi J. Sofia - NHGRI, NIH, Bethesda, MD 20892 USA
William D. Travis
Richard Cheney
Belinda Clarke
Sanja Dacic
Edwina Duhig - Prince Charles Hosp, Brisbane, Qld 4032, Australia
William K. Funkhouser
Peter Illei
Carol Farver
Natasha Rekhtman
Gabriel Sica
James Suh
Ming-Sound Tsao
Canc Genome Atlas Res Network
Détails de publication: Nature (London), Vol.511(7511), pp.543-550
Éditeur: Springer Nature
Nombre de pages: 8
Note de subvention: U24 CA143867; U24 CA143848; U24 CA143840; U24 CA143835; U24 CA143799; U24 CA143883; U24 CA143843; U54 HG003067; U54 HG003079; U54 HG003273 / The NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 1054631 / Direct For Computer & Info Scie & Enginr; National Science Foundation (NSF); NSF - Directorate for Computer & Information Science & Engineering (CISE) U24 CA126561; U24 CA126551; U24 CA126554; U24 CA126543; U24 CA126546; U24 CA137153; U24 CA126563; U24 CA126544; U24 CA143845; U24 CA143858; U24 CA144025; U24 CA143882; U24 CA143866 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32GM007753 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) U54HG003079 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) U24CA143845 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) UL1TR000005 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
Identifiants: 99163771309311
Unité académique: Institut Amélioration Génétique & Adaptation des Plantes méditerranéennes & tropicales-AGAP
Langue: English
Type de ressource: Journal article