Comparison of Kaposi Sarcoma Risk in Human Immunodeficiency Virus-Positive Adults Across 5 Continents: A Multiregional Multicohort Study

Eliane Rohner; Lukas Butikofer; Kurt Schmidlin; Mazvita Sengayi; Mhairi Maskew; Janet Giddy; Daniela Garone; Richard D. Moore; Gypsamber D'Souza; James J. Goedert; Chad Achenbach; M. John Gill; Mari M. Kitahata; Pragna Patel; Michael J. Silverberg; Jessica Castilho; Catherine McGowan; Yi-Ming Arthur Chen; Matthew Law; Ninon Taylor; Vassilios Paparizos; Fabrice Bonnet; Annelies Verbon; Gerd Fatkenheuer; Frank A. Post; Caroline Sabin; Amanda Mocroft; Vincent Le Moing; Fernando Dronda; Niels Obel; Sophie Grabar; Vincenzo Spagnuolo; Andrea Antinori; Eugenia Quiros-Roldan; Cristina Mussini; Jose M. Miro; Laurence Meyer; Barbara Hasse; Deborah Konopnicki; Bernardino Roca; Diana Barger; Dorthe Raben; Gary M. Clifford; Silva Franceschi; Norbert Brookmeyer; Rana Chakraborty; Matthias Egger; Julia Bohlius; Aids-Defining Canc Project

doi:10.1093/cid/cix480

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Comparison of Kaposi Sarcoma Risk in Human Immunodeficiency Virus-Positive Adults Across 5 Continents: A Multiregional Multicohort Study

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Comparison of Kaposi Sarcoma Risk in Human Immunodeficiency Virus-Positive Adults Across 5 Continents: A Multiregional Multicohort Study

Eliane Rohner, Lukas Butikofer, Kurt Schmidlin, Mazvita Sengayi, Mhairi Maskew, Janet Giddy, Daniela Garone, Richard D. Moore, Gypsamber D'Souza, James J. Goedert, …

Clinical infectious diseases, Vol.65(8), pp.1316-1326

15/10/2017

DOI: https://doi.org/10.1093/cid/cix480

PMID: 28531260

Résumé

Immunology

Infectious Diseases

Life Sciences & Biomedicine

Microbiology

Science & Technology

Background. We compared Kaposi sarcoma (KS) risk in adults who started antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America. Methods. We included cohort data of human immunodeficiency virus (HIV)-positive adults who started ART after 1995 within the framework of 2 large collaborations of observational HIV cohorts. We present incidence rates and adjusted hazard ratios (aHRs). Results. We included 208 140 patients from 57 countries. Over a period of 1 066 572 person-years, 2046 KS cases were diagnosed. KS incidence rates per 100 000 person-years were 52 in the Asia-Pacific and ranged between 180 and 280 in the other regions. KS risk was 5 times higher in South African women (aHR, 4.56; 95% confidence intervals [CI], 2.73-7.62) than in their European counterparts, and 2 times higher in South African men (2.21; 1.34-3.63). In Europe, Latin, and North America KS risk was 6 times higher in men who have sex with men (aHR, 5.95; 95% CI, 5.09-6.96) than in women. Comparing patients with current CD4 cell counts >= 700 cells/mu L with those whose counts were <50 cells/mu L, the KS risk was halved in South Africa (aHR, 0.53; 95% CI,.17-1.63) but reduced by >= 95% in other regions. Conclusions. Despite important ART-related declines in KS incidence, men and women in South Africa and men who have sex with men remain at increased KS risk, likely due to high human herpesvirus 8 coinfection rates. Early ART initiation and maintenance of high CD4 cell counts are essential to further reducing KS incidence worldwide, but additional measures might be needed, especially in Southern Africa.

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Titre: Comparison of Kaposi Sarcoma Risk in Human Immunodeficiency Virus-Positive Adults Across 5 Continents: A Multiregional Multicohort Study
Créateurs - sans rôle: Eliane Rohner - Univ Bern, Inst Social & Prevent Med, Finkenhubelweg 11, CH-3012 Bern, Switzerland
Lukas Butikofer - Univ Bern, CTU Bern, Bern, Switzerland
Kurt Schmidlin - Univ Bern, Inst Social & Prevent Med, Finkenhubelweg 11, CH-3012 Bern, Switzerland
Mazvita Sengayi - Natl Hlth Lab Serv, Natl Canc Registry, Johannesburg, South Africa
Mhairi Maskew - Univ Witwatersrand, Sch Clin Med, Dept Internal Med, Hlth Econ & Epidemiol Res Off, Johannesburg, South Africa
Janet Giddy - McCord Hosp, Dept Med, Durban, South Africa
Daniela Garone - Med Sans Frontieres Belgium, Brussels, Belgium
Richard D. Moore - Johns Hopkins Univ, Sch Med, Baltimore, MD USA
Gypsamber D'Souza - Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA
James J. Goedert - Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD USA
Chad Achenbach - Northwestern Univ, Ctr Global Hlth, Feinberg Sch Med, Chicago, IL USA
M. John Gill - Univ Calgary, Calgary, AB, Canada
Mari M. Kitahata - Univ Washington, Sch Med, Seattle, WA USA
Pragna Patel - Div HIV AIDS Prevent, Centers Dis Control & Prevent, Atlanta, GA USA
Michael J. Silverberg - Kaiser Permanente Calif, Div Res, Oakland, CA USA
Jessica Castilho - Vanderbilt Univ, Med Ctr, Nashville, TN USA
Catherine McGowan - Vanderbilt Univ, Med Ctr, Nashville, TN USA
Yi-Ming Arthur Chen - Kaohsiung Med Univ, Kaohsiung, Taiwan
Matthew Law - UNSW Sydney
Ninon Taylor - Paracelsus Med Univ, Med Dept Haematol Med Oncol Haemostaseol Infect, Ctr Oncol, Salzburg, Austria
Vassilios Paparizos - Syngros Hosp, Athens Med Sch, AIDS Unit, Clin Venereol & Dermatol Dis, Athens, Greece
Fabrice Bonnet - Hop St Andre, CHU Bordeaux, Serv Med Interne & Malad Infect, Bordeaux, France
Annelies Verbon - Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
Gerd Fatkenheuer - Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany
Frank A. Post - Kings Coll Hosp NHS Fdn Trust, London, England
Caroline Sabin - UCL, Res Dept Infect Populat Hlth, London, England
Amanda Mocroft - UCL, Res Dept Infect Populat Hlth, London, England
Vincent Le Moing - Montpellier Univ, Montpellier, France
Fernando Dronda - Hosp Ramon & Cajal, Dept Infect Dis, Madrid, Spain
Niels Obel - Copenhagen Univ Hosp, Dept Infect Dis, Copenhagen, Denmark
Sophie Grabar - UPMC Univ Paris 06, UMR S 1136, Sorbonne Univ, Inst Pierre Louis Epidemiol & Sante Publ, F-75013 Paris, France
Vincenzo Spagnuolo - Ist Sci San Raffaele, Dept Infect Dis, Milan, Italy
Andrea Antinori - INMI Spallanzani, Rome, Italy
Eugenia Quiros-Roldan - Univ Brescia, Infect & Trop Dis Inst, Brescia, Italy
Cristina Mussini - Univ Hosp, Infect Dis Clin, Modena, Italy
Jose M. Miro - Univ Barcelona, Hosp Clin IDIBAPS, Infect Dis Serv, Barcelona, Spain
Laurence Meyer - Univ Paris Sud, INSERM, Epidemiol HIV, Reprod Paediat,CESP, F-U1018 Paris, France
Barbara Hasse - Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland
Deborah Konopnicki - Univ Libre Bruxelles, St Pierre Univ Hosp, Dept Infect Dis, Brussels, Belgium
Bernardino Roca - Hosp Gen Univ, Castellon de La Plana, Spain
Diana Barger - Ctr INSERM U1219 Bordeaux Populat Hlth, INSERM, ISPED, F-33000 Bordeaux, France
Dorthe Raben - Rigshosp, CHIP, Dept Infect Dis, Copenhagen, Denmark
Gary M. Clifford - Int Agcy Res Canc, Lyon, France
Silva Franceschi - Int Agcy Res Canc, Lyon, France
Norbert Brookmeyer - Ruhr Univ Bochum, St Josef Hosp, Dept Dermatol Venerol & Allergol, Ctr Sexual Hlth & Med, Bochum, Germany
Rana Chakraborty - Emory Univ, Dept Pediat, Div Infect Dis, Sch Med, Atlanta, GA USA
Matthias Egger - Univ Bern, Inst Social & Prevent Med, Finkenhubelweg 11, CH-3012 Bern, Switzerland
Julia Bohlius - Univ Bern, Inst Social & Prevent Med, Finkenhubelweg 11, CH-3012 Bern, Switzerland
Aids-Defining Canc Project
Détails de publication: Clinical infectious diseases, Vol.65(8), pp.1316-1326
Éditeur: Oxford Univ Press
Nombre de pages: 11
Note de subvention: PZ00P3_160407 / Swiss National Science Foundation; Swiss National Science Foundation (SNSF) CBR-86906; CBR-94036; HCP-97105; TGF-96118 / Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) Janssen-Cilag; Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc ViiV Healthcare National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) Ontario Ministry of Health and Long Term Care; Ontario Ministere de la Sante et des Soins de longue duree (MSSLD) National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 260694 / European Union Seventh Framework Programme (FP7); European Union (EU); Marie Curie Actions Australian Government Department of Health and Ageing; Australian Government; Australian Department of Health PZ00P3_160407 / Swiss National Science Foundation (SNF); Swiss National Science Foundation (SNSF)
Identifiants: 99148907509311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article