Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Fergus J. Couch; Mia M. Gaudet; Antonis C. Antoniou; Susan J. Ramus; Karoline B. Kuchenbaecker; Penny Soucy; Jonathan Beesley; Xiaoqing Chen; Xianshu Wang; Tomas Kirchhoff; Lesley McGuffog; Daniel Barrowdale; Andrew Lee; Sue Healey; Olga M. Sinilnikova; Irene L. Andrulis; Hilmi Ozcelik; Anna Marie Mulligan; Mads Thomassen; Anne-Marie Gerdes; Uffe Birk Jensen; Anne-Bine Skytte; Torben A. Kruse; Maria A. Caligo; Anna von Wachenfeldt; Gisela Barbany-Bustinza; Niklas Loman; Maria Soller; Hans Ehrencrona; Per Karlsson; Katherine L. Nathanson; Timothy R. Rebbeck; Susan M. Domchek; Ania Jakubowska; Jan Lubinski; Katarzyna Jaworska; Katarzyna Durda; Elzbieta Zlowocka; Tomasz Huzarski; Tomasz Byrski; Jacek Gronwald; Cezary Cybulski; Bohdan Gorski; Ana Osorio; Mercedes Duran; Maria Isabel Tejada; Javier Benitez; Ute Hamann; Frans B. L. Hogervorst; Theo A. van Os; Flora E. van Leeuwen; Hanne E. J. Meijers-Heijboer; Juul Wijnen; Marinus J. Blok; Marleen Kets; Maartje J. Hooning; Rogier A. Oldenburg; Margreet G. E. M. Ausems; Susan Peock; Debra Frost; Steve D. Ellis; Radka Platte; Elena Fineberg; D. Gareth Evans; Chris Jacobs; Rosalind A. Eeles; Julian Adlard; Rosemarie Davidson; Diana M. Eccles; Trevor Cole; Jackie Cook; Joan Paterson; Carole Brewer; Fiona Douglas; Shirley V. Hodgson; Patrick J. Morrison; Lisa Walker; Mary E. Porteous; M. John Kennedy; Lucy E. Side; Betsy Bove; Andrew K. Godwin; Dominique Stoppa-Lyonnet; Marion Fassy-Colcombet; Laurent Castera; Francois Cornelis; Sylvie Mazoyer; Melanie Leone; Nadia Boutry-Kryza; Brigitte Bressac-de Paillerets; Olivier Caron; Pascal Pujol; Isabelle Coupier; Capucine Delnatte; Linda Akloul; Henry T. Lynch; Carrie L. Snyder; Saundra S. Buys; Mary B. Daly; MaryBeth Terry; Wendy K. Chung; Esther M. John; Alexander Miron; Melissa C. Southey; John L. Hopper; David E. Goldgar; Christian F. Singer; Christine Rappaport; Muy-Kheng M. Tea; Anneliese Fink-Retter; Thomas V. O. Hansen; Finn C. Nielsen; Adalgeir Arason; Joseph Vijai; Sohela Shah; Kara Sarrel; Mark E. Robson; Marion Piedmonte; Kelly Phillips; Jack Basil; Wendy S. Rubinstein; John Boggess; Katie Wakeley; Amanda Ewart-Toland; Marco Montagna; Simona Agata; Evgeny N. Imyanitov; Claudine Isaacs; Ramunas Janavicius; Conxi Lazaro; Ignacio Blanco; Lidia Feliubadalo; Joan Brunet; Simon A. Gayther; Paul P. D. Pharoah; Kunle O. Odunsi; Beth Y. Karlan; Christine S. Walsh; Edith Olah; Soo Hwang Teo; Patricia A. Ganz; Mary S. Beattie; Elizabeth J. van Rensburg; Cecelia M. Dorfling; Orland Diez; Ava Kwong; Rita K. Schmutzler; Barbara Wappenschmidt; Christoph Engel; Alfons Meindl; Nina Ditsch; Norbert Arnold; Simone Heidemann; Dieter Niederacher; Sabine Preisler-Adams; Dorothea Gadzicki; Raymonda Varon-Mateeva; Helmut Deissler; Andrea Gehrig; Christian Sutter; Karin Kast; Britta Fiebig; Wolfram Heinritz; Trinidad Caldes; Miguel de la Hoya; Taru A. Muranen; Heli Nevanlinna; Marcd Tischkowitz; Amanda B. Spurdle; Susan L. Neuhausen; Yuan Chun Ding; Noralane M. Lindor; Zachary Fredericksen; V. Shane Pankratz; Paolo Peterlongo; Siranoush Manoukian; Bernard Peissel; Daniela Zaffaroni; Monica Barile; Loris Bernard; Alessandra Viel; Giuseppe Giannini; Liliana Varesco; Paolo Radice; Mark H. Greene; Phuong L. Mai; Douglas F. Easton; Georgia Chenevix-Trench; Kenneth Offit; Jacques Simard; kConFab Investigators

doi:10.1158/1055-9965.EPI-11-0888

Retour

Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Article de revue

Avec comité de lecture

Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Fergus J. Couch, Mia M. Gaudet, Antonis C. Antoniou, Susan J. Ramus, Karoline B. Kuchenbaecker, Penny Soucy, Jonathan Beesley, Xiaoqing Chen, Xianshu Wang, Tomas Kirchhoff, …

Cancer epidemiology, biomarkers & prevention, Vol.21(4), pp.645-657

2012

DOI: https://doi.org/10.1158/1055-9965.EPI-11-0888

PMID: 22351618

Résumé

Life Sciences & Biomedicine

Oncology

Public, Environmental & Occupational Health

Science & Technology

Background: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Methods: Genotyping data for 12,599 BRCA1 and 7,132 BRCA2 mutation carriers from 40 studies were combined. Results: We confirmed associations between rs8170 at 19p13.1 and breast cancer risk for BRCA1 mutation carriers [HR, 1.17; 95% confidence interval (CI), 1.07-1.27; P = 7.42 x 10(-4)] and between rs16917302 at ZNF365 (HR, 0.84; 95% CI, 0.73-0.97; P = 0.017) but not rs311499 at 20q13.3 (HR, 1.11; 95% CI, 0.94-1.31; P = 0.22) and breast cancer risk for BRCA2 mutation carriers. Analyses based on tumor histopathology showed that 19p13 variants were predominantly associated with estrogen receptor (ER)-negative breast cancer for both BRCA1 and BRCA2 mutation carriers, whereas rs16917302 at ZNF365 was mainly associated with ER-positive breast cancer for both BRCA1 and BRCA2 mutation carriers. We also found for the first time that rs67397200 at 19p13.1 was associated with an increased risk of ovarian cancer for BRCA1 (HR, 1.16; 95% CI, 1.05-1.29; P = 3.8 x 10(-4)) and BRCA2 mutation carriers (HR, 1.30; 95% CI, 1.10-1.52; P = 1.8 x 10(-3)). Conclusions: 19p13.1 and ZNF365 are susceptibility loci for ovarian cancer and ER subtypes of breast cancer among BRCA1 and BRCA2 mutation carriers. Impact: These findings can lead to an improved understanding of tumor development and may prove useful for breast and ovarian cancer risk prediction for BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev; 21(4); 645-57. (C) 2012 AACR.

Indicateurs

1 Consultations de la notice

See more details

Détails

Titre: Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Créateurs - sans rôle: Fergus J. Couch - Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
Mia M. Gaudet - Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
Antonis C. Antoniou - Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB2 1TN, England
Susan J. Ramus - Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA
Karoline B. Kuchenbaecker - University of Cambridge
Penny Soucy - Ctr Hosp Univ Quebec, Canc Genom Lab, Quebec City, PQ, Canada
Jonathan Beesley - Queensland Inst Med Res, Dept Genet, Herston, Qld 4006, Australia
Xiaoqing Chen - Queensland Inst Med Res, Dept Genet, Herston, Qld 4006, Australia
Xianshu Wang - Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
Tomas Kirchhoff - Mem Sloane Kettering Canc Ctr, Clin Canc Genet Lab, New York, NY USA
Lesley McGuffog - Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB2 1TN, England
Daniel Barrowdale - Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB2 1TN, England
Andrew Lee - Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB2 1TN, England
Sue Healey - Queensland Inst Med Res, Dept Genet, Herston, Qld 4006, Australia
Olga M. Sinilnikova - Ctr Hosp Univ Lyon, Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, Lyon, France
Irene L. Andrulis - University of Toronto
Hilmi Ozcelik - University of Toronto
Anna Marie Mulligan - University of Toronto
Mads Thomassen - Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Anne-Marie Gerdes - Rigshosp, Dept Clin Genet, Copenhagen, Denmark
Uffe Birk Jensen - Skejby Hosp, Dept Clin Genet, Aarhus, Denmark
Anne-Bine Skytte - Vejle Hosp, Dept Clin Genet, Vejle, Denmark
Torben A. Kruse - Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Maria A. Caligo - Univ Hosp Pisa, Sect Genet Oncol, Pisa, Italy
Anna von Wachenfeldt - Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden
Gisela Barbany-Bustinza - Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden
Niklas Loman - Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden
Maria Soller - Univ Lund Hosp, Dept Clin Genet, S-22185 Lund, Sweden
Hans Ehrencrona - Uppsala University
Per Karlsson - Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden
Katherine L. Nathanson - Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Dept Med, Philadelphia, PA 19104 USA
Timothy R. Rebbeck - Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
Susan M. Domchek - Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Dept Med, Philadelphia, PA 19104 USA
Ania Jakubowska - Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Jan Lubinski - University of Szczecin
Katarzyna Jaworska - Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Katarzyna Durda - University of Szczecin
Elzbieta Zlowocka - Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Tomasz Huzarski - University of Szczecin
Tomasz Byrski - University of Szczecin
Jacek Gronwald - University of Szczecin
Cezary Cybulski - University of Szczecin
Bohdan Gorski - University of Szczecin
Ana Osorio - Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain
Mercedes Duran - Univ Valladolid IBGM UVA, Inst Biol & Mol Genet, Valladolid, Spain
Maria Isabel Tejada - Cruces Hosp Barakaldo, Dept Biochem, Mol Genet Lab, Bizkaia, Spain
Javier Benitez - Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain
Ute Hamann - Deutsch Krebsforschungszentrum DKFZ, Heidelberg, Germany
Frans B. L. Hogervorst - Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands
Theo A. van Os - Acad Med Ctr, Dept Clin Genet, Forfar, Angus, Scotland
Flora E. van Leeuwen - Netherlands Canc Inst, Dept Epidemiol, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands
Hanne E. J. Meijers-Heijboer - Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands
Juul Wijnen - Leiden University
Marinus J. Blok - Univ Med Ctr, Dept Genet & Cell Biol, Maastricht, Netherlands
Marleen Kets - Radboud Univ Nijmegen, Med Ctr, Hereditary Canc Clin, NL-6525 ED Nijmegen, Netherlands
Maartje J. Hooning - Erasmus Univ, Med Ctr, Family Canc Clin, Dept Med Oncol, Rotterdam, Netherlands
Rogier A. Oldenburg - Erasmus Univ, Med Ctr, Family Canc Clin, Dept Clin Genet, Rotterdam, Netherlands
Margreet G. E. M. Ausems - Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
Susan Peock - Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB2 1TN, England
Debra Frost - Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB2 1TN, England
Steve D. Ellis - Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB2 1TN, England
Radka Platte - Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB2 1TN, England
Elena Fineberg - Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB2 1TN, England
D. Gareth Evans - Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Chris Jacobs - Guys & St Thomas NHS Fdn Trust, London, England
Rosalind A. Eeles - Inst Canc Res, Oncogenet Team, London, England
Julian Adlard - Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England
Rosemarie Davidson - Yorkhill Hosp, Ferguson Smith Ctr Clin Genet, Glasgow, Lanark, Scotland
Diana M. Eccles - University of Southampton
Trevor Cole - Birmingham Womens Hosp Healthcare NHS Trust, W Midlands Reg Genet Serv, Birmingham, W Midlands, England
Jackie Cook - Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England
Joan Paterson - Addenbrookes Hosp, E Anglian Reg Genet Serv, Dept Clin Genet, Cambridge, England
Carole Brewer - Royal Devon University Healthcare NHS Foundation Trust
Fiona Douglas - Newcastle Upon Tyne Hosp NHS Trust, Inst Med Genet, Ctr Life, Newcastle Upon Tyne, Tyne & Wear, England
Shirley V. Hodgson - University of London
Patrick J. Morrison - Belfast Hlth & Social Care Trust, No Ireland Reg Genet Ctr, Belfast, Antrim, North Ireland
Lisa Walker - Churchill Hosp, Oxford Reg Genet Serv, Oxford, England
Mary E. Porteous - Western Gen Hosp, SE Scotland Reg Genet Serv, Edinburgh EH4 2XU, Midlothian, Scotland
M. John Kennedy - Trinity Coll Dublin, Acad Unit Clin & Mol Oncol, Dublin, Ireland
Lucy E. Side - Great Ormond St Hosp Sick Children, NE Thames Reg Genet Serv, London, England
Betsy Bove - Clin Mol Genet Lab, Philadelphia, PA USA
Andrew K. Godwin - University of Kansas
Dominique Stoppa-Lyonnet - Federat Natl Ctr Lutte Canc, GEMO Study Collaborators Canc Genet Network, Grp Genet & Canc, Lyon, France
Marion Fassy-Colcombet - Univ Paris 05, Fac Med, Paris, France
Laurent Castera - Univ Paris 05, Fac Med, Paris, France
Francois Cornelis - Assistance Publique – Hôpitaux de Paris
Sylvie Mazoyer - Univ Lyon 1, Ctr Rech Cancerol Lyon, CNRS, INSERM,UMR5286,U1052, F-69622 Villeurbanne, France
Melanie Leone - Ctr Hosp Univ Lyon, Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, Lyon, France
Nadia Boutry-Kryza - Ctr Hosp Univ Lyon, Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, Lyon, France
Brigitte Bressac-de Paillerets - Inst Cancerol Gustave Roussy, Dept Genet, Villejuif, France
Olivier Caron - Inst Cancerol Gustave Roussy, Dept Med, Villejuif, France
Pascal Pujol - CHU Arnaud Villeneuve, Unite Oncogenet, Montpellier, France
Isabelle Coupier - CHU Arnaud Villeneuve, Unite Oncogenet, Montpellier, France
Capucine Delnatte - Université de Nantes
Linda Akloul - Université de Nantes
Henry T. Lynch - Creighton Univ, Dept Prevent Med, Omaha, NE 68178 USA
Carrie L. Snyder - Creighton Univ, Dept Prevent Med, Omaha, NE 68178 USA
Saundra S. Buys - University of Utah
Mary B. Daly - Fox Chase Canc Ctr, Philadelphia, PA USA
MaryBeth Terry - Columbia Univ, Dept Epidemiol, New York, NY USA
Wendy K. Chung - Columbia Univ, Dept Epidemiol, New York, NY USA
Esther M. John - Canc Prevent Inst Calif, Dept Epidemiol, Fremont, CA USA
Alexander Miron - Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
Melissa C. Southey - Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Melbourne, Vic 3010, Australia
John L. Hopper - Univ Melbourne, Peter MacCallum Canc Ctr, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia
David E. Goldgar - University of Utah
Christian F. Singer - University of Vienna
Christine Rappaport - University of Vienna
Muy-Kheng M. Tea - Med Univ Vienna, Dept OB GYN, Vienna, Austria
Anneliese Fink-Retter - Med Univ Vienna, Dept OB GYN, Vienna, Austria
Thomas V. O. Hansen - Copenhagen Univ Hosp, Rigshosp, Ctr Genom Med, Copenhagen, Denmark
Finn C. Nielsen - Copenhagen Univ Hosp, Rigshosp, Ctr Genom Med, Copenhagen, Denmark
Adalgeir Arason - Landspitali Univ Hosp, Dept Pathol, Liborius, Iceland
Joseph Vijai - Mem Sloane Kettering Canc Ctr, Clin Canc Genet Lab, New York, NY USA
Sohela Shah - Mem Sloane Kettering Canc Ctr, Clin Canc Genet Lab, New York, NY USA
Kara Sarrel - Mem Sloane Kettering Canc Ctr, Clin Canc Genet Lab, New York, NY USA
Mark E. Robson - Mem Sloane Kettering Canc Ctr, Clin Canc Genet Lab, New York, NY USA
Marion Piedmonte - Roswell Pk Canc Inst, Gynecol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA
Kelly Phillips - Univ Melbourne, Peter MacCallum Canc Ctr, Div Canc Med, Melbourne, Vic, Australia
Jack Basil - GOGaffilitate, Dept Obstet & Gynecol, Good Samaritan Hosp, Cincinnati, OH USA
Wendy S. Rubinstein - NorthShore Univ Hlth Syst, Ctr Med Genet, Evanston, IL USA
John Boggess - Univ N Carolina, Chapel Hill, NC USA
Katie Wakeley - S Shore Hosp, Dana Farber Brigham & Womens Canc Ctr, S Weymouth, MA USA
Amanda Ewart-Toland - Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol, Columbus, OH 43210 USA
Marco Montagna - Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Simona Agata - Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Evgeny N. Imyanitov - NN Petrov Inst Oncol, Oncol Mol Lab, St Petersburg, Russia
Claudine Isaacs - Georgetown University
Ramunas Janavicius - Vilnius University
Conxi Lazaro - IDIBELL Catalan Inst Oncol, Hereditari Canc Program, Mol Diagnost Unit, Barcelona, Spain
Ignacio Blanco - IDIBELL Catalan Inst Oncol, Hereditari Canc Program, Genet Counseling Unit, Barcelona, Spain
Lidia Feliubadalo - IDIBELL Catalan Inst Oncol, Hereditari Canc Program, Mol Diagnost Unit, Barcelona, Spain
Joan Brunet - IDIBELL Catalan Inst Oncol, Hereditari Canc Program, Genet Counseling Unit, Barcelona, Spain
Simon A. Gayther - Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA
Paul P. D. Pharoah - Univ Cambridge, Dept Oncol, Cambridge CB2 1TN, England
Kunle O. Odunsi - Roswell Pk Canc Inst, Dept Gynecol Oncol, Buffalo, NY 14263 USA
Beth Y. Karlan - College Station Medical Center
Christine S. Walsh - College Station Medical Center
Edith Olah - Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary
Soo Hwang Teo - Univ Malaya, Univ Malaya Canc Res Inst, Breast Canc Res Unit, Subang Jaya, Malaysia
Patricia A. Ganz - Univ Calif Los Angeles, Sch Publ Hlth, Dept Hlth Serv, Los Angeles, CA 90024 USA
Mary S. Beattie - Univ Calif San Francisco, Dept Med Epidemiol & Biostat, San Francisco, CA 94143 USA
Elizabeth J. van Rensburg - University of Pretoria
Cecelia M. Dorfling - Univ Pretoria, Dept Genet, Canc Genet Lab, ZA-0002 Pretoria, South Africa
Orland Diez - Vall dHebron Univ Hosp, VHIO, Oncogenet Lab, Mol Med & Genet Program, Barcelona, Spain
Ava Kwong - Hong Kong Sanat & Hosp, Hong Kong Hereditary Breast Canc Family Registry, Hong Kong, Hong Kong, Peoples R China
Rita K. Schmutzler - Univ Hosp Cologne, Dept Obstet & Gynaecol, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Barbara Wappenschmidt - Univ Hosp Cologne, Dept Obstet & Gynaecol, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Christoph Engel - Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany
Alfons Meindl - Ludwig-Maximilians-Universität München
Nina Ditsch - Ludwig-Maximilians-Universität München
Norbert Arnold - Univ Kiel, Univ Hosp Schleswig Holstein, Dept Obstet & Gynaecol, Kiel, Germany
Simone Heidemann - Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Kiel, Germany
Dieter Niederacher - Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Obstet & Gynaecol, D-40225 Dusseldorf, Germany
Sabine Preisler-Adams - Univ Munster, Inst Human Genet, D-4400 Munster, Germany
Dorothea Gadzicki - Hannover Med Sch, Inst Cell & Mol Pathol, D-3000 Hannover, Germany
Raymonda Varon-Mateeva - Campus Virchov Klinikum, Inst Human Genet, Berlin, Germany
Helmut Deissler - Univ Hosp Ulm, Dept Obstet & Gynaecol, Ulm, Germany
Andrea Gehrig - University of Würzburg
Christian Sutter - Heidelberg Univ, Div Mol Genet, Inst Human Genet, D-6900 Heidelberg, Germany
Karin Kast - Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Obstet & Gynaecol, D-01062 Dresden, Germany
Britta Fiebig - Univ Regensburg, Inst Human Genet, Regensburg, Germany
Wolfram Heinritz - Univ Leipzig, Inst Human Genet, Leipzig, Germany
Trinidad Caldes - Hosp Clin San Carlos, Mol Oncol Lab, Madrid, Spain
Miguel de la Hoya - Hosp Clin San Carlos, Mol Oncol Lab, Madrid, Spain
Taru A. Muranen - Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
Heli Nevanlinna - Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
Marcd Tischkowitz - McGill Univ, Dept Human Genet, Program Canc Genet, Montreal, PQ H3A 2T5, Canada
Amanda B. Spurdle - Queensland Inst Med Res, Dept Genet, Herston, Qld 4006, Australia
Susan L. Neuhausen - Beckman Research Institute
Yuan Chun Ding - Beckman Research Institute
Noralane M. Lindor - Mayo Clin, Dept Med Genet, Rochester, MN 55905 USA
Zachary Fredericksen - Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA
V. Shane Pankratz - Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA
Paolo Peterlongo - Fdn Ist FIRC Oncol Mol, Unit Mol Bases Genet Risk & Genet Testing, Dept Prevent & Predicted Med, Barcelona, Spain
Siranoush Manoukian - Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predicted Med, Milan, Italy
Bernard Peissel - Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predicted Med, Milan, Italy
Daniela Zaffaroni - Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predicted Med, Milan, Italy
Monica Barile - Ist Europeo Oncol, Div Canc Prevent & Genet, Milan, Italy
Loris Bernard - Ist Europeo Oncol, Dept Expt Oncol, Milan, Italy
Alessandra Viel - IRCCS, Ctr Riferimento Oncol, Unit Expt Oncol 1, Aviano, PN, Italy
Giuseppe Giannini - Univ Roma La Sapienza, Dept Expt Med, Rome, Italy
Liliana Varesco - Ist Nazl Ric Cancro IST, Dept Epidemiol Prevent & Special Funct, Unit Hereditary Canc, Genoa, Italy
Paolo Radice - Fdn Ist FIRC Oncol Mol, Unit Mol Bases Genet Risk & Genet Testing, Dept Prevent & Predicted Med, Barcelona, Spain
Mark H. Greene - NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA
Phuong L. Mai - NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA
Douglas F. Easton - Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge CB2 1TN, England
Georgia Chenevix-Trench - Queensland Inst Med Res, Dept Genet, Herston, Qld 4006, Australia
Kenneth Offit - Mem Sloane Kettering Canc Ctr, Clin Canc Genet Lab, New York, NY USA
Jacques Simard - Ctr Hosp Univ Quebec, Canc Genom Lab, Quebec City, PQ, Canada
kConFab Investigators
Détails de publication: Cancer epidemiology, biomarkers & prevention, Vol.21(4), pp.645-657
Éditeur: Amer Assoc Cancer Research
Nombre de pages: 13
Note de subvention: BIO07/CA/006 / Basque Foundation for Health Innovation and Research (BIOEF) Fundacion Mutua Madrilena; Instituto de Salud Carlos III Fondazione Italiana per la Ricerca sul Cancro; Fondazione AIRC per la ricerca sul cancro 132473 / Academy of Finland; Research Council of Finland Autonomous Government of Catalonia; Generalitat de Catalunya AICR-07-0454 / Association for International Cancer Research Grant Komen Foundation for the Cure; Susan G. Komen Breast Cancer Foundation 223175 (HEALTH-F2-2009-223175) / European Community C1287/A10118; C1287/A11990 / CR-UK; Cancer Research UK Kate and Robert Niehaus Clinical Cancer Research Initiative
Identifiants: 99159054109311
Unité académique: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Langue: English
Type de ressource: Journal article