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Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”
Journal article   Open access   Peer reviewed

Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

Abdel Aouacheria, Kyle Cunningham, J. Marie Marie Hardwick, Zdena Palková, Ted Powers, Fedor Severin and Libuše Váchová
Science, Vol.360(6395)
21/06/2018

Abstract

Apoptosis/immunology Aspergillosis/immunology* Aspergillus fumigatus/immunology* Cell Death Humans Lung/immunology
Shlezinger et al (Reports, 8 September 2017, p. 1037) report that the common fungus Aspergillus fumigatus, a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin.
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