Logo image
Se connecter
Comment on "A Centrosome-Independent Role for γ-TuRC Proteins in the Spindle Assembly Checkpoint"
Article de revue   Avec comité de lecture

Comment on "A Centrosome-Independent Role for γ-TuRC Proteins in the Spindle Assembly Checkpoint"

Stephen S. Taylor, Kevin G. Hardwick, Kenneth E. Sawin, Sue Biggins, Simonetta Piatti, Alexey Khodjakov, Conly L. Rieder, Edward D. Salmon et Andrea Musacchio
Science (American Association for the Advancement of Science), Vol.316(5827), pp.982-982
18/05/2007
PMID: 17510347

Résumé

Müller et al . (Reports, 27 October 2006, p. 654) showed that inhibition of the γ-tubulin ring complex (γ-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that γ-TuRC proteins play molecular roles in SAC activation. Because γ-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.

Indicateurs

1 Consultations de la notice

Détails

Logo image