Combined Hepatocellular-Cholangiocarcinoma compared to Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: different survival, similar recurrence. Report of a large study on repurposed databases with propensity score matching

Boris Amory; Claire Goumard; Alexis Laurent; Serena Langella; Daniel Cherqui; Ephrem Salame; Louise Barbier; Olivier Soubrane; Olivier Farges; Christian Hobeika; Takayuki Kawai; Jean-Marc Regimbeau; François Faitot; Patrick Pessaux; Stéphanie Truant; Emmanuel Boleslawski; Astrid Herrero; Jean-Yves Mabrut; Laurence Chiche; Marcello DI MARTINO; Rami Rhaiem; Lilian Schwarz; Vivian Resende; Julien Calderaro; Jérémy Augustin; Stefano Caruso; Daniele Sommacale; Stefan Hofmeyr; Alessandro Ferrero; David Fuks; Eric Vibert; Guido Torzilli; Olivier Scatton; Raffaele Brustia; Julio Abba; René Adam; Mustapha Adham; Pietro Addeo; Marc-Antoine Allard; Giuliana Amaddeo; Ahmet Ayav; Daniel Azoulay; Philippe Bachellier; Pierre Balladur; Julien Barbieux; Karim Boudjema; M. Bougard; Emmanuel Buc; Petru Bucur; Antoine Carmelo; François Cauchy; Denis Chatelain; Jean Chauvat; Zineb Cherkaoui; Mircea Chirica; Oriana Ciacio; Tatiana Codjia; Fabio Colli; Luciano DE Carlis; D.E.L.P.E.R.O. Jean-Robert; Nicolas Demartines; Olivier Detry; Marcelo DIAS SANCHES; Momar Diouf; Alexandre Doussot; Christian Ducerf; Mehdi El AMRANI; Jacques Ewald; Jean-Marc Fabre; Hervé Fagot; Simone Famularo; Léo Ferre; Francesco Fleres; Gilton Marques FONSECA; Álvaro GANCEDO QUINTANA; Brice Gayet; Alessandro Giacomoni; Jean-Francois Gigot; Nicolas Golse; Emilie Gregoire; Jean Hardwigsen; Paulo Herman; Thevi Hor; François Jehaes; Ali-Reza Kianmanesh; Shohei Komatsu; Sophie Laroche; Christophe Laurent; Yves-Patrice LE TREUT; Philippe Leourier; Emilie Lermite; Mikael Lesurtel; Christian Letoublon; Paul Leyman; Mickael Lesurtel; Jean Lubrano; Georges Mantion; Ugo Marchese; Elena MARTÍN-PÉREZ; Benjamin Menahem; Maxime Meunier; Guillaume Millet; Kayvan Mohkam; André Mulliri; Fabrice Muscari; Francis Navarro; Francisco Nolasco; Takeo Nomi; Jean Nunoz; Gennaro Nuzzo; Shinya Okumura; Nassima Oudafal; Gerard Pascal; Guillaume Passot; Damiano Patrono; François Paye; Fabiano Perdigao; Niccolo Petrucciani; Gabriella Pittau; François-René Pruvot; Artigas Raventos; Hélène Regnault; Michel Rivoire; Renato Romagnoli; Didier Roulin; Antonio SA-CUNHA; Michel Scotte; François-Regis Souche; Bertrand Suc; Alexandre Thobie; Boris Trechot; Olivier Turini; Shinji Uemoto; Xavier Unterteiner; Charles Vanbrugghe; Jean Zemour; AFC-ICC-2009, AFC-LLR-2018 and PRS-2019 Study group

doi:10.1016/j.surg.2023.09.040

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Combined Hepatocellular-Cholangiocarcinoma compared to Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: different survival, similar recurrence. Report of a large study on repurposed databases with propensity score matching

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Combined Hepatocellular-Cholangiocarcinoma compared to Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: different survival, similar recurrence. Report of a large study on repurposed databases with propensity score matching

Boris Amory, Claire Goumard, Alexis Laurent, Serena Langella, Daniel Cherqui, Ephrem Salame, Louise Barbier, Olivier Soubrane, Olivier Farges, Christian Hobeika, …

Surgery, Vol.175(2), pp.413-423

01/02/2024

DOI: https://doi.org/10.1016/j.surg.2023.09.040

PMID: 37981553

Résumé

Combined hepatocholangiocarcinoma

Intra-hepatic cholangiocarcinoma

Liver surgery

long-term outcomes

propensity-score matching

reducing waste in research

Combined hepatocholangiocarcinoma (cHCC-CCA) is a rare cancer with a grim prognosis composed of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) morphological patterns in the same tumor. The aim of this multi-centre, international cohort study was to compare the oncological outcomes after surgery of cHCC-CCA, compared to HCC and iCCA. Patients treated by surgery for cHCC-CCA, HCC and iCCA from 2000 to 2021 from multicenter international databases were analyzed retrospectively. Patients with cHCC-CCA (cases) were compared with two control groups of HCC or iCCA, sequentially matched using a propensity score (PSM) based on eight preoperative characteristics. Overall (OS) and disease-free survival (DFS) were compared, and predictors of mortality and recurrence were analyzed with Cox regression after PSM. During the study period 3196 patients were included. Propensity score adjustment and two sequential matching processes produced a new cohort (n=244) comprising three balanced groups was obtained (cHCC-CCA=56, iCCA=66 and HCC =122). Kaplan–Meier OS estimations at 1, 3 and 5 years were 67%, 45% and 28% for cHCC-CCA, 92%, 75% and 55% for HCC and 86%, 53% and 42% for iCCA group, respectively (p=0.0014). Estimations of DFS at 1, 3 and 5 years were 51%, 25% and 17% for cHCC-CCA, 63%, 35% and 26% for HCC group and 51%, 31% and 28% for iCCA group, respectively (p=0.19). Predictors of mortality were cHCC-CCA subtype, metabolic syndrome, preoperative tumor markers (AFP and CA 19-9), and satellite nodules, while recurrence was associated with satellite nodules rather than cancer subtype. Despite data limitations, OS among patients with cHCC-CCA was worse than both groups and closer iCCA, whereas DFS was similar among the 3 groups. Future research on immunophenotypic profiling may hold more promise than traditional non-modifiable clinical characteristics (as found in this study) in predicting recurrence or response to salvage treatments.

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Titre: Combined Hepatocellular-Cholangiocarcinoma compared to Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: different survival, similar recurrence. Report of a large study on repurposed databases with propensity score matching
Créateurs - sans rôle: Boris Amory - Department of Digestive and Hepato-pancreatic-biliary Surgery, AP-HP, Hôpital Henri-Mondor, Paris Est Créteil University, UPEC, Créteil, France. Assistance Publique-Hôpitaux de Paris, Créteil, France
Claire Goumard - Assistance Publique – Hôpitaux de Paris
Alexis Laurent - Department of Digestive and Hepato-pancreatic-biliary Surgery, DMU CARE, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, F-94010 Créteil, France. Paris Est Créteil University, UPEC, F-94010 Créteil, France. Team "Pathophysiology and Therapy of Chronic Viral Hepatitis and Related Cancers", INSERM U955, Créteil, France. Assistance Publique-Hôpitaux de Paris, Créteil, France
Serena Langella - Department of General and Oncological Surgery, Ospedale Mauriziano, Torino, Italy
Daniel Cherqui - Assistance Publique – Hôpitaux de Paris
Ephrem Salame - Department of Digestive Surgery and Liver Transplantation, University Hospital of Tours, University of Tours, Tours, France. FHU Support, Tours, France
Louise Barbier - Department of Digestive Surgery and Liver Transplantation, University Hospital of Tours, University of Tours, Tours, France. FHU Support, Tours, France
Olivier Soubrane - Department of Digestive, Oncological, and Metabolic Surgery, Institut Mutualiste Montsouris, Paris, France
Olivier Farges - Department of HPB Surgery and Liver Transplantation, AP-HP Beaujon Hospital, University of Paris, Clichy, France
Christian Hobeika - Department of HPB Surgery and Liver Transplantation, AP-HP Beaujon Hospital, University of Paris, Clichy, France
Takayuki Kawai - Department of Surgery, Medical Research Institute, Kitano Hospital, Osaka and Graduate School of Medicine, Kyoto University, Kyoto, Japan
Jean-Marc Regimbeau - SSPC (Simplification of Surgical Patients Care) - Clinical Research Unit, University of Picardie Jules Verne, 80054, Amiens, France. Department of Digestive Surgery, Amiens University Medical Center, 1 Rond-Point du Professeur Christian Cabrol, 80054, Amiens, France
François Faitot - Service de Chirurgie Hépato-Biliaire et Transplantation Hépatique, Hôpital de Hautepierre, Strasbourg, France
Patrick Pessaux
Stéphanie Truant - Department of Digestive Surgery and Transplantation, University Hospitals, Lille, France
Emmanuel Boleslawski - Department of Digestive Surgery and Transplantation, University Hospitals, Lille, France
Astrid Herrero - Department of HBP Surgery and Liver Transplantation, Montpellier University Hospital, University of Montpellier, 34295 Montpellier, France
Jean-Yves Mabrut - Croix Rousse University Hospital, Department of General Surgery and Liver Transplantation, Lyon, France. The Cancer Research Center of Lyon, INSERM U1052, Lyon, France
Laurence Chiche
Marcello DI MARTINO - HPB Unit, Department of General and Digestive Surgery, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain
Rami Rhaiem
Lilian Schwarz - Department of Genomic and Personalized Medicine in Cancer and Neurological Disorders, Rouen University Hospital, UNIROUEN, UMR 1245 INSERM, Normandie ROUEN University, 76000, Rouen, France
Vivian Resende - Federal University of Minas Gerais School of Medicine, Belo Horizonte, Brazil
Julien Calderaro
Jérémy Augustin
Stefano Caruso
Daniele Sommacale - Hôpitaux Universitaires Henri-Mondor
Stefan Hofmeyr - Division of Surgery, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa
Alessandro Ferrero - Department of General and Oncological Surgery, Ospedale Mauriziano, Torino, Italy
David Fuks
Eric Vibert - Assistance Publique – Hôpitaux de Paris
Guido Torzilli - Division of Hepatobiliary and General Surgery, Department of Surgery, Humanitas Research Hospital - IRCCS, Humanitas University, 20089, Rozzano, Milan, Italy
Olivier Scatton - Assistance Publique – Hôpitaux de Paris
Raffaele Brustia - Department of Digestive and Hepato-pancreatic-biliary Surgery, DMU CARE, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, F-94010 Créteil, France. Paris Est Créteil University, UPEC, F-94010 Créteil, France. Team "Pathophysiology and Therapy of Chronic Viral Hepatitis and Related Cancers", INSERM U955, Créteil, France. Assistance Publique-Hôpitaux de Paris, Créteil, France
Julio Abba
René Adam
Mustapha Adham
Pietro Addeo
Marc-Antoine Allard
Giuliana Amaddeo
Ahmet Ayav
Daniel Azoulay
Philippe Bachellier
Pierre Balladur
Julien Barbieux
Emmanuel Boleslawski
Karim Boudjema
M. Bougard
Emmanuel Buc
Petru Bucur
Antoine Carmelo
François Cauchy
Denis Chatelain
Jean Chauvat
Zineb Cherkaoui
Mircea Chirica
Oriana Ciacio
Tatiana Codjia
Fabio Colli
Luciano DE Carlis
D.E.L.P.E.R.O. Jean-Robert
Nicolas Demartines
Olivier Detry
Marcelo DIAS SANCHES
Momar Diouf
Alexandre Doussot
Christian Ducerf
Mehdi El AMRANI
Jacques Ewald
Jean-Marc Fabre
Hervé Fagot
Simone Famularo
Léo Ferre
Francesco Fleres
Gilton Marques FONSECA
Álvaro GANCEDO QUINTANA
Brice Gayet
Alessandro Giacomoni
Jean-Francois Gigot
Nicolas Golse
Emilie Gregoire
Jean Hardwigsen
Paulo Herman
Thevi Hor
François Jehaes
Ali-Reza Kianmanesh
Shohei Komatsu
Sophie Laroche
Christophe Laurent
Yves-Patrice LE TREUT
Philippe Leourier
Emilie Lermite
Mikael Lesurtel
Christian Letoublon
Paul Leyman
Mickael Lesurtel
Jean Lubrano
Jean-Yves Mabrut
Georges Mantion
Ugo Marchese
Elena MARTÍN-PÉREZ
Benjamin Menahem
Maxime Meunier
Guillaume Millet
Kayvan Mohkam
André Mulliri
Fabrice Muscari
Francis Navarro
Francisco Nolasco
Takeo Nomi
Jean Nunoz
Gennaro Nuzzo
Shinya Okumura
Nassima Oudafal
Gerard Pascal
Guillaume Passot
Damiano Patrono
François Paye
Fabiano Perdigao
Niccolo Petrucciani
Gabriella Pittau
François-René Pruvot
Artigas Raventos
Hélène Regnault
Michel Rivoire
Renato Romagnoli
Didier Roulin
Antonio SA-CUNHA
Michel Scotte
François-Regis Souche
Bertrand Suc
Alexandre Thobie
Boris Trechot
Stéphanie Truant
Olivier Turini
Shinji Uemoto
Xavier Unterteiner
Charles Vanbrugghe
Jean Zemour
AFC-ICC-2009, AFC-LLR-2018 and PRS-2019 Study group
Détails de publication: Surgery, Vol.175(2), pp.413-423
Éditeur: Elsevier Inc
Identifiants: 99141105509311
Unité académique: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Langue: English
Type de ressource: Journal article