Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019)

Xue Li; Nicolas Semiramoth; Shaun Hall; Virginie Tafani; Jérôme Josse; Frédéric Laurent; Giuseppina Salzano; Daniel Foulkes; Priscille Brodin; Laleh Majlessi; Nour‐eddine Ghermani; Guillaume Maurin; Patrick Couvreur; Christian Serre; Marie‐françoise Bernet‐camard; Jiwen Zhang; Ruxandra Gref

doi:10.1002/ppsc.201970009

Retour

Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019)

Article de revue

Open Access

Avec comité de lecture

Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019)

Xue Li, Nicolas Semiramoth, Shaun Hall, Virginie Tafani, Jérôme Josse, Frédéric Laurent, Giuseppina Salzano, Daniel Foulkes, Priscille Brodin, Laleh Majlessi, …

Particle & Particle Systems Characterization, Vol.36(3)

07/01/2019

DOI: https://doi.org/10.1002/ppsc.201970009

Résumé

coencapsulation

molecular simulations

macrophage

antibiotic

metal–organic frameworks nanoparticles

Back Cover : As demonstrated by Ruxendra Gref and co‐workers in article number 1800360, two synergic drugs, amoxicillin and potassium clavulanate, were co‐encapsulated within highly porous nanoparticles made of metal‐organic frameworks (nanoMOFs). Within the interconnected 3D structure, each drug located in a separate compartment and these findings were supported by molecular simulations. NanoMOFs were efficiently internalized in infected macrophages and contributed together with the entrapped drugs to kill intracellular bacteria.

Fichiers et liens (2)

url

Find in HALAfficher

url

https://doi.org/10.1002/ppsc.201970009Afficher

Published (Version of record) Ouvrir

Indicateurs

1 Consultations de la notice

Détails

Titre: Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019)
Créateurs - sans rôle: Xue Li - Centre National de la Recherche Scientifique
Nicolas Semiramoth - Institut Galien Paris-Saclay
Shaun Hall - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Virginie Tafani - Hospices Civils de Lyon
Jérôme Josse - Hôpital de la Croix-Rousse
Frédéric Laurent - Inserm
Giuseppina Salzano - Université Paris-Saclay
Daniel Foulkes - Institut des Sciences Moléculaires d'Orsay
Priscille Brodin - Inserm
Laleh Majlessi - Institut Pasteur
Nour‐eddine Ghermani - Institut Galien Paris-Saclay
Guillaume Maurin - Université de Montpellier, Institut Charles Gerhardt Montpellier - ICGM
Patrick Couvreur - Institut Galien Paris-Saclay
Christian Serre - Chimie ParisTech
Marie‐françoise Bernet‐camard - Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion
Jiwen Zhang - Shanghai Institute of Materia Medica
Ruxandra Gref - Centre National de la Recherche Scientifique
Détails de publication: Particle & Particle Systems Characterization, Vol.36(3)
Note de subvention: This research was funded by the European Union through Cyclon Hit project (People‐2013‐ITN), Grant Agreement 608407. This work was supported by a public grant overseen by the French National Research Agency (ANR) as part of the “Investissements d'Avenir” program (Labex NanoSaclay, reference: ANR‐10‐LABX‐0035). The authors acknowledge support from the French ANR projects AntiTBnano (ANR‐14‐CE08‐0017) and Virmil (ANR‐2010‐RMNP‐004‐01). G.M. thanks Institut Universitaire de France for its support.
Identifiants: 99150274409311
Unité académique: Institut Charles Gerhardt Montpellier - ICGM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-02367416