Co-op CARs for targeting acute myeloid leukemia

Taisuke Kondo; Naomi Taylor

doi:10.1016/j.ccell.2023.09.015

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Co-op CARs for targeting acute myeloid leukemia

Journal article

Open access

Peer reviewed

Co-op CARs for targeting acute myeloid leukemia

Taisuke Kondo and Naomi Taylor

Cancer Cell, Vol.41(11), pp.1841-1843

11/2023

DOI: https://doi.org/10.1016/j.ccell.2023.09.015

PMID: 37832553

Abstract

Humans

Leukemia, Myeloid, Acute

Immunotherapy, Adoptive

Chimeric antigen receptor (CAR) T cell therapies are limited by antigen escape and on-target/off-tumor toxicity. In addressing these challenges, Haubner et al. develop an "IF-BETTER" strategy. Their combinatorial chimeric co-stimulatory receptor with an attenuated CAR enhances acute myeloid leukemia (AML) killing while protecting healthy progenitors, highlighting the potential to leverage cooperative CAR designs.

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Details

Title: Co-op CARs for targeting acute myeloid leukemia
Creators - without role: Taisuke Kondo - National Cancer Institute
Naomi Taylor - National Cancer Institute
Publication Details: Cancer Cell, Vol.41(11), pp.1841-1843
Grant note: This work was partially supported by the Intramural Research Program, Center of Cancer Research, National Cancer Institute, National Institutes of Health (ZIA BC 011923 and NCI Flex Synergy Award to N.T).
Identifiers: 9937421909311
Academic Unit: Institut de Génétique Moléculaire de Montpellier - IGMM
Language: English
Resource Type: Journal article
Local Fields: hal-04918431