Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview

Constance Delaby; Aurélie Ladang; Jose Martinez-Yriarte; Chiara Zecca; Giancarlo Logroscino; Peter Körtvelyessy; Hayrettin Tumani; Piero Parchi; Isabelle Quadrio; Melanie Hart; Dorte Aalund Olsen; Daniel Alcolea; Kaj Blennow; Juan Fortea; Alberto Lleo; Alicia Algeciras-Schimnich; Xavier Ayrignac; Aurélie Bedel; Gustavo A A Santos; Wyllians Borelli; Elodie Bouaziz-Amar; Inês Baldeiras; Edith Bigot-Corbel; Maria Bjerke; Mercedes Carretero Perez; Tiziana Casoli; Tinatin Chabrashvili; Miles D Chapman; Jessica Cusato; Erdinc Dursun; Anthony Fourier; Daniela Galimberti; Duygu Gezen-Ak; Brian A Gordon; Julien Gouju; Silvia de Las Heras Florez; Juanjo Hernandez Sanchez; Marina Herwerth; Daniele Imperiale; Flora Kaczorowski; Kensaku Kasuga; Ashvini Keshavan; Michael Khalil; Jens Kuhle; Christoph Leithner; Piotr Lewczuk; Franck Letournel; Magda Tsolaki; Guido Maria Giuffrè; Marie-Céline Blanc; Barbara Mroczko; Jose Enrique Martínez Rodríguez; Giulia Musso; Agnieszka Kulczynska-Przybik; Léonor Nogueira; Claire Paquet; Simone Baiardi; Lorenzo Gaetani; Lucilla Parnetti; Raquel Perez Garay; Koen Poesen; Muriel Quillard-Muraine; Enrique Rodriguez Borja; Susanna Schraen; Daniela Terracciano; Franziska Bachhuber; Steffen Halbgebauer; Socrates Tzartos; John Tzartos; Nadine Unterwalder; Lisa Vermunt; Cheryl L Wellington; Henrik Zetterberg; Charlotte Teunissen; Sylvain Lehmann

doi:10.1002/alz.70343

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Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview

Article de revue

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Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview

Constance Delaby, Aurélie Ladang, Jose Martinez-Yriarte, Chiara Zecca, Giancarlo Logroscino, Peter Körtvelyessy, Hayrettin Tumani, Piero Parchi, Isabelle Quadrio, Melanie Hart, …

Alzheimer's & dementia, Vol.21(6), pp.e70343-n/a

06/2025

DOI: https://doi.org/10.1002/alz.70343

PMID: 40551293

Résumé

Biomarkers - blood

Biomarkers - cerebrospinal fluid

Humans

Nervous System Diseases - cerebrospinal fluid

Nervous System Diseases - diagnosis

Neurofilament Proteins - blood

Neurofilament Proteins - cerebrospinal fluid

Practice Guidelines as Topic

Surveys and Questionnaires

Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the global analytical and post-analytical methods used for NfL measurement in routine clinical practice across different contexts. We established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements. Among the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both. COU was widespread, with 50% defining pathological cutoffs based on publications and 42% considering age. Reporting was primarily done through numeric results (95%). Harmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice. Unique international overview of current analytical and post-analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice. Tailored sheets for each neurological application. Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.

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Titre: Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview
Créateurs - sans rôle: Constance Delaby - Department of Unitat de Memoria, Hospital de la Santa Creu iSant Pau - Biomedical Research Institute Sant Pau - Universitat Autònoma de Barcelona, Barcelona, Spain
Aurélie Ladang - Clinical chemistry department, CHU de Liège, Liège, Belgium
Jose Martinez-Yriarte - Clinical analysis service, Hospital do Meixoeiro, Área Sanitaria de Vigo, Vigo, Spain
Chiara Zecca - Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari "A. Moro" at Pia Fondazione "Cardinale G. Panico", Tricase, Lecce, Italy
Giancarlo Logroscino - Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari "A. Moro" at Pia Fondazione "Cardinale G. Panico", Tricase, Lecce, Italy
Peter Körtvelyessy - Labor Berlin, Division Innovation, Berlin, Germany
Hayrettin Tumani - Universität Ulm
Piero Parchi - Department of Clinical Neurobiology, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
Isabelle Quadrio - Hospices Civils de Lyon
Melanie Hart - UCL Queen Square Institute of Neurology
Dorte Aalund Olsen - Department of Biochemistry and Immunology, University hospital of southern Denmark, Odense, Southern Denmark, Denmark
Daniel Alcolea - Centro de Investigación Biomédica en Red
Kaj Blennow - University of Gothenburg
Juan Fortea - Centro de Investigación Biomédica en Red
Alberto Lleo - Centro de Investigación Biomédica en Red
Alicia Algeciras-Schimnich - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
Xavier Ayrignac - Inserm
Aurélie Bedel - Centre Hospitalier Universitaire de Bordeaux
Gustavo A A Santos - Department of Food and Nutrition, Faculty of Food Engineering, University of Campinas, São Paulo, Brazil
Wyllians Borelli - Department of Biochemistry, University of Rio Grande do Sul, Porto Alegre, Brazil
Elodie Bouaziz-Amar - Université Paris Cité
Inês Baldeiras - University of Coimbra
Edith Bigot-Corbel - Department of Biochimie, CHU Nantes, Nantes, France
Maria Bjerke - Vrije Universiteit Brussel
Mercedes Carretero Perez - Department of Neurology, Santa Cruz de Tenerife, Tenerife, Spain
Tiziana Casoli - Department of Neurobiology of Ageing, IRCCS INRCA, Ancona, Italy
Tinatin Chabrashvili - Department of Neurology, SUNY Upstate Medical University, Syracuse, New York, USA
Miles D Chapman - National Hospital for Neurology and Neurosurgery
Jessica Cusato - Department of Medical Sciences, UNITO, Turin, Italy
Erdinc Dursun - Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey
Anthony Fourier - Biochemistry and Molecular Biology Department, Neurodegenerative Pathologies LBMMS Hospices Civils de Lyon, BIORAN Team Lyon Neurosciences Research Center CNRS UMR 5292 INSERM U1028, Lyon, France
Daniela Galimberti - IRCCS, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy
Duygu Gezen-Ak - Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey
Brian A Gordon - Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA
Julien Gouju - MINT, INSERM U1066, CNRS 6021, CHU Angers, Angers, France
Silvia de Las Heras Florez - Department of Neurology, Hospital Universitario Nuestra Señora de Candelaria Santa Cruz de Tenerife, Santa Cruz, Spain
Juanjo Hernandez Sanchez - Department of Neurology, Unitat de Neuroquímica, Laboratori de Referència de Catalunya, Barcelona, Spain
Marina Herwerth - Neurology Department, University Hospital Zurich, Zurich, Switzerland
Daniele Imperiale - Department of Medical Sciences, UNITO, Turin, Italy
Flora Kaczorowski - Biochemistry and Molecular Biology Department, Neurodegenerative Pathologies LBMMS Hospices Civils de Lyon, BIORAN Team Lyon Neurosciences Research Center CNRS UMR 5292 INSERM U1028, Lyon, France
Kensaku Kasuga - Niigata University
Ashvini Keshavan - UCL Queen Square Institute of Neurology
Michael Khalil - Medical University of Graz
Jens Kuhle - University Hospital of Basel
Christoph Leithner - Department of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany
Piotr Lewczuk - Medical University of Białystok
Franck Letournel - MINT, INSERM U1066, CNRS 6021, CHU Angers, Angers, France
Magda Tsolaki - AHEPA University Hospital
Guido Maria Giuffrè - Department of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy
Marie-Céline Blanc - Biochemistry Department, Cochin hospital, APHP, Paris, France
Barbara Mroczko - Department of Neurology, Medical University of Bialystok, Bialystok, Poland
Jose Enrique Martínez Rodríguez - Servei de Neurologia, Neuroimmunology group Hospital del Mar, IMIM, Barcelona, Spain
Giulia Musso - Department of Medicine, University of Padova, Padova, Italy
Agnieszka Kulczynska-Przybik - Department of Neurology, Medical University of Bialystok, Bialystok, Poland
Léonor Nogueira - UMR 5165 CNRS, CHU-PURPAN, Toulouse, France
Claire Paquet - Department of Neurologie Cognitive, Université de Paris Cité, Paris, France
Simone Baiardi - Department of Clinical Neurobiology, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
Lorenzo Gaetani - University of Perugia
Lucilla Parnetti - University of Perugia
Raquel Perez Garay - Department of Clinical Analysis Service, Cruces University Hospital-OSAKIDETZA, Immunopathology Research Group, Biobizkaia Health Research Institute, Barakaldo, Spain
Koen Poesen - KU Leuven
Muriel Quillard-Muraine - Clinical Biology Center, Rouen University Hospital, Rouen, France
Enrique Rodriguez Borja - Hospital Clinico Universitario de Valencia Laboratorio de Bioquimica Clínica y Patología Molecular, Valencia, Spain
Susanna Schraen - Centre Hospitalier Universitaire de Lille
Daniela Terracciano - Department of Translational Medical Sciences, University Federico II, Naples, Italy
Franziska Bachhuber - Department of Translational Medical Sciences, University Federico II, Naples, Italy
Steffen Halbgebauer - Universität Ulm
Socrates Tzartos - Tzartos NeuroDiagnostics, Athens, Greece
John Tzartos - Department of Neurology, Second Department of Neurology, National & Kapodistrian University of Athens, Athens, Greece
Nadine Unterwalder - Department of Neurology, LaborBerlin, Berlin, Germany
Lisa Vermunt - Vrije Universiteit Amsterdam
Cheryl L Wellington - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Henrik Zetterberg - Department of Clinical Neurochemistry, University of Gothenburg, Mölndal, Gothenburg, Sweden
Charlotte Teunissen - Vrije Universiteit Amsterdam
Sylvain Lehmann - Inserm
Détails de publication: Alzheimer's & dementia, Vol.21(6), pp.e70343-n/a
Identifiants: 99140102809311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article