Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Constance Delaby; Charlotte Teunissen; Kaj Blennow; Daniel Alcolea; Ivan Arisi; Elodie Bouaziz Amar; Anne Beaume; Aurélie Bedel; Giovanni Bellomo; Edith Bigot‐corbel; Maria Bjerke; Marie‐céline Blanc‐quintin; Mercè Boada; Olivier Bousiges; Miles Chapman; Mari Demarco; Mara d'Onofrio; Julien Dumurgier; Diane Dufour-Rainfray; Sebastiaan Engelborghs; Hermann Esselmann; Anne Fogli; Audrey Gabelle; Elisabetta Galloni; Clémentine Gondolf; Frédérique Grandhomme; Oriol Grau‐rivera; Melanie Hart; Takeshi Ikeuchi; Andreas Jeromin; Kensaku Kasuga; Ashvini Keshavan; Michael Khalil; Peter Körtvelyessy; Agnieszka Kulczynska‐przybik; Jean‐louis Laplanche; Piotr Lewczuk; Qiao‐xin Li; Alberto Lleó; Catherine Malaplate; Marta Marquié; Colin Masters; Barbara Mroczko; Léonor Nogueira; Adelina Orellana; Markus Otto; Jean‐baptiste Oudart; Claire Paquet; Federico Paolini Paoletti; Lucilla Parnetti; Armand Perret-Liaudet; Katell Peoc'H; Koen Poesen; Albert Puig‐pijoan; Isabelle Quadrio; Muriel Quillard‐muraine; Benoit Rucheton; Susanna Schraen; Jonathan Schott; Leslie Shaw; Marc Suárez‐calvet; Magda Tsolaki; Hayrettin Tumani; Chinedu Udeh‐momoh; Lucie Vaudran; Marcel Verbeek; Federico Verde; Lisa Vermunt; Jonathan Vogelgsang; Jens Wiltfang; Henrik Zetterberg; Sylvain Lehmann

doi:10.1002/alz.12545

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Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Journal article

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Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Constance Delaby, Charlotte Teunissen, Kaj Blennow, Daniel Alcolea, Ivan Arisi, Elodie Bouaziz Amar, Anne Beaume, Aurélie Bedel, Giovanni Bellomo, Edith Bigot‐corbel, …

Alzheimer's & Dementia : the Journal of the Alzheimer's Association

2022

DOI: https://doi.org/10.1002/alz.12545

Abstract

Alzheimer’s disease

cerebrospinal fluid biomarkers

clinical report

consensus approach

harmonization

Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests.Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients.Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis.Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.

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Title: Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
Creators - without role: Constance Delaby - Université de Montpellier
Charlotte Teunissen - Amsterdam University Medical Centers
Kaj Blennow - University of Gothenburg
Daniel Alcolea - Universitat Autònoma de Barcelona
Ivan Arisi - European Brain Research Institute
Elodie Bouaziz Amar - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
Anne Beaume - Centre Hospitalier Universitaire de Poitiers
Aurélie Bedel - Centre Hospitalier Universitaire de Bordeaux
Giovanni Bellomo - University of Perugia
Edith Bigot‐corbel - Centre Hospitalier Universitaire de Nantes
Maria Bjerke - Universitair Ziekenhuis Brussel
Marie‐céline Blanc‐quintin - Assistance Publique – Hôpitaux de Paris
Mercè Boada - Fundació ACE
Olivier Bousiges - Hôpitaux Universitaires de Strasbourg
Miles Chapman - University College London
Mari Demarco - Providence Health Care
Mara d'Onofrio - European Brain Research Institute
Julien Dumurgier - Hôpital Fernand-Widal
Diane Dufour-Rainfray - Centre Hospitalier Universitaire de Tours
Sebastiaan Engelborghs - Vrije Universiteit Brussel
Hermann Esselmann - University Medical Center Göttingen
Anne Fogli - Centre Hospitalier Universitaire de Clermont-Ferrand
Audrey Gabelle - Université de Montpellier
Elisabetta Galloni
Clémentine Gondolf - Centre Hospitalier Universitaire de Caen
Frédérique Grandhomme - Centre Hospitalier Universitaire de Caen
Oriol Grau‐rivera - Barcelonaβeta Brain Research Center
Melanie Hart - National Hospital for Neurology and Neurosurgery
Takeshi Ikeuchi - Niigata University
Andreas Jeromin - Cohen Veterans Bioscience
Kensaku Kasuga - Niigata University
Ashvini Keshavan - University College London
Michael Khalil - Medical University of Graz
Peter Körtvelyessy - Humboldt-Universität zu Berlin
Agnieszka Kulczynska‐przybik - Medical University of Białystok
Jean‐louis Laplanche - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
Piotr Lewczuk - Medical University of Białystok
Qiao‐xin Li - Florey Institute of Neuroscience and Mental Health
Alberto Lleó - Hospital de Sant Pau
Catherine Malaplate - Université de Lorraine
Marta Marquié - Fundació ACE
Colin Masters - Florey Institute of Neuroscience and Mental Health
Barbara Mroczko - Medical University of Białystok
Léonor Nogueira - Centre Hospitalier Universitaire de Toulouse
Adelina Orellana - Fundació ACE
Markus Otto - Universität Ulm
Jean‐baptiste Oudart - Centre National de la Recherche Scientifique
Claire Paquet - Assistance Publique – Hôpitaux de Paris
Federico Paolini Paoletti - University of Perugia
Lucilla Parnetti - University of Perugia
Armand Perret-Liaudet - Inserm
Katell Peoc'H - Hôpital Beaujon
Koen Poesen - VIB-KU Leuven Center for Brain & Disease Research
Albert Puig‐pijoan - Hospital del Mar Research Institute
Isabelle Quadrio - Inserm
Muriel Quillard‐muraine - Université de Rouen Normandie
Benoit Rucheton - Sorbonne Université
Susanna Schraen - Inserm
Jonathan Schott - UK Dementia Research Institute
Leslie Shaw - University of Pennsylvania
Marc Suárez‐calvet - Barcelonaβeta Brain Research Center
Magda Tsolaki - Aristotle University of Thessaloniki
Hayrettin Tumani - Universität Ulm
Chinedu Udeh‐momoh - Imperial College London
Lucie Vaudran - Université de Lille
Marcel Verbeek - Radboud University Nijmegen
Federico Verde - IRCCS Istituto Auxologico Italiano
Lisa Vermunt - Amsterdam University Medical Centers
Jonathan Vogelgsang - Harvard University
Jens Wiltfang - German Center for Neurodegenerative Diseases
Henrik Zetterberg - University College London
Sylvain Lehmann - Université de Montpellier
Publication Details: Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Identifiers: 9933740209311
Academic Unit: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Language: English
Resource Type: Journal article
Local Fields: hal-03599269