Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data

Salim Abdulla; Ishag Adam; George O. Adjei; Martin A. Adjuik; Bereket Alemayehu; Richard Allan; Emmanuel Arinaitwe; Elizabeth A. Ashley; Mamadou S. Ba; Hubert Barennes; Karen I. Barnes; Quique Bassat; Elisabeth Baudin; Nicole Berens-Riha; Anders Bjoerkman; Francois Bompart; Maryline Bonnet; Steffen Borrmann; Teun Bousema; Philippe Brasseur; Hasifa Bukirwa; Francesco Checchi; Prabin Dahal; Umberto D'Alessandro; Meghna Desai; Alassane Dicko; Abdoulaye A. Djimde; Grant Dorsey; Ogobara K. Doumbo; Chris J. Drakeley; Stephan Duparc; Teferi Eshetu; Emmanuelle Espie; Jean-Francois Etard; Abul M. Faiz; Catherine O. Falade; Caterina I. Fanello; Jean-Francois Faucher; Babacar Faye; Oumar Faye; Scott Filler; Jennifer A. Flegg; Bakary Fofana; Carole Fogg; Nahla B. Gadalla; Oumar Gaye; Blaise Genton; Peter W. Gething; Jose P. Gil; Raquel Gonzalez; Francesco Grandesso; Bryan Greenhouse; Brian Greenwood; Anastasia Grivoyannis; Philippe J. Guerin; Jean-Paul Guthmann; Kamal Hamed; Sally Hamour; Simon I. Hay; Eva Maria Hodel; Georgina S. Humphreys; Jimee Hwang; Maman L. Ibrahim; Daddi Jima; Joel J. Jones; Vincent Jullien; Elizabeth Juma; Patrick S. Kachur; Piet A. Kager; Erasmus Kamugisha; Moses R. Kamya; Corine Karema; Kassoum Kayentao; Jean-Rene Kiechel; Fred Kironde; Poul-Erik Kofoed; Peter G. Kremsner; Sanjeev Krishna; Valerie Lameyre; Bertrand Lell; Angeles Lima; Michael Makanga; ElFatih M. Malik; Kevin Marsh; Andreas Martensson; Achille Massougbodji; Herve Menan; Didier Menard; Clara Menendez; Petra F. Mens; Martin Meremikwu; Clarissa Moreira; Carolyn Nabasumba; Michael Nambozi; Jean-Louis Ndiaye; Billy E. Ngasala; Frederic Nikiema; Christian Nsanzabana; Francine Ntoumi; Mary Oguike; Bernhards R. Ogutu; Piero Olliaro; Sabah A. Omar; Jean-Bosco Ouedraogo; Seth Owusu-Agyei; Louis K. Penali; Mbaye Pene; Judy Peshu; Patrice Piola; Christopher V. Plowe; Zul Premji; Ric N. Price; Milijaona Randrianarivelojosia; Lars Rombo; Cally Roper; Philip J. Rosenthal; Issaka Sagara; Albert Same-Ekobo; Patrick Sawa; Henk D. F. H. Schallig; Birgit Schramm; Amadou Seck; Seif A. Shekalaghe; Carol H. Sibley; Vronique Sinou; Sodiomon B. Sirima; Fabrice A. Som; Doudou Sow; Sarah G. Staedke; Kasia Stepniewska; Colin J. Sutherland; Todd D. Swarthout; Khadime Sylla; Ambrose O. Talisuna; Walter R. J. Taylor; Emmanuel A. Temu; Julie I. Thwing; Roger C. K. Tine; Halidou Tinto; Silva Tommasini; Offianan A. Toure; Johan Ursing; Michel T. Vaillant; Giovanni Valentini; Ingrid Van den Broek; Michele Van Vugt; Stephen A. Ward; Peter A. Winstanley; William Yavo; Adoke Yeka; Yah M. Zolia; Issaka Zongo; WWARN Artemisinin Based

doi:10.1186/s12916-015-0445-x

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Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data

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Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data

Salim Abdulla, Ishag Adam, George O. Adjei, Martin A. Adjuik, Bereket Alemayehu, Richard Allan, Emmanuel Arinaitwe, Elizabeth A. Ashley, Mamadou S. Ba, Hubert Barennes, …

BMC medicine, Vol.13(1), pp.212-16

07/09/2015

DOI: https://doi.org/10.1186/s12916-015-0445-x

PMID: 26343145

Résumé

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

Science & Technology

Background: Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong sub-region and poses a major global public health threat. Slow parasite clearance is a key clinical manifestation of reduced susceptibility to artemisinin. This study was designed to establish the baseline values for clearance in patients from Sub-Saharan African countries with uncomplicated malaria treated with artemisinin-based combination therapies (ACTs). Methods: A literature review in PubMed was conducted in March 2013 to identify all prospective clinical trials (uncontrolled trials, controlled trials and randomized controlled trials), including ACTs conducted in Sub-Saharan Africa, between 1960 and 2012. Individual patient data from these studies were shared with the WorldWide Antimalarial Resistance Network (WWARN) and pooled using an a priori statistical analytical plan. Factors affecting early parasitological response were investigated using logistic regression with study sites fitted as a random effect. The risk of bias in included studies was evaluated based on study design, methodology and missing data. Results: In total, 29,493 patients from 84 clinical trials were included in the analysis, treated with artemether-lumefantrine (n = 13,664), artesunate-amodiaquine (n = 11,337) and dihydroartemisinin-piperaquine (n = 4,492). The overall parasite clearance rate was rapid. The parasite positivity rate (PPR) decreased from 59.7 % (95 % CI: 54.5-64.9) on day 1 to 6.7 % (95 % CI: 4.8-8.7) on day 2 and 0.9 % (95 % CI: 0.5-1.2) on day 3. The 95th percentile of observed day 3 PPR was 5.3 %. Independent risk factors predictive of day 3 positivity were: high baseline parasitaemia (adjusted odds ratio (AOR) = 1.16 (95 % CI: 1.08-1.25); per 2-fold increase in parasite density, P <0.001); fever (>37.5 degrees C) (AOR = 1.50 (95 % CI: 1.06-2.13), P = 0.022); severe anaemia (AOR = 2.04 (95 % CI: 1.21-3.44), P = 0.008); areas of low/moderate transmission setting (AOR = 2.71 (95 % CI: 1.38-5.36), P = 0.004); and treatment with the loose formulation of artesunate-amodiaquine (AOR = 2.27 (95 % CI: 1.14-4.51), P = 0.020, compared to dihydroartemisinin-piperaquine). Conclusions: The three ACTs assessed in this analysis continue to achieve rapid early parasitological clearance across the sites assessed in Sub-Saharan Africa. A threshold of 5 % day 3 parasite positivity from a minimum sample size of 50 patients provides a more sensitive benchmark in Sub-Saharan Africa compared to the current recommended threshold of 10 % to trigger further investigation of artemisinin susceptibility.

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Titre: Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data
Créateurs - sans rôle: Salim Abdulla - Ifakara Hlth Inst, Dar Es Salaam, Tanzania
Ishag Adam - Univ Khartoum, Fac Med, Khartoum, Sudan
George O. Adjei - Univ Ghana, Sch Med, Ctr Trop Clin Pharmacol & Therapeut, Accra, Ghana
Martin A. Adjuik - INDEPTH Network Secretariat, Accra, Ghana
Bereket Alemayehu - Int Ctr AIDS Care & Treatment Programs, Addis Ababa, Ethiopia
Richard Allan - Mentor
Emmanuel Arinaitwe - Infect Dis Res Collaborat, Kampala, Uganda
Elizabeth A. Ashley - Epictr, Paris, France
Mamadou S. Ba - Univ Cheikh Anta Diop, Dept Parasitol & Mycol, Fac Med, Dakar, Senegal
Hubert Barennes - Ctr Muraz, Bobo Dioulasso, Burkina Faso
Karen I. Barnes - WorldWide Antimalarial Resistance Network WWARN, Cape Town, South Africa
Quique Bassat - Ctr Invest Saude Manhica, Manhica, Mozambique
Elisabeth Baudin - MENTOR Initiat, Crawley, England
Nicole Berens-Riha - Univ Munich LMU, Med Ctr, Div Infect Dis & Trop Med, Munich, Germany
Anders Bjoerkman - Karolinska Inst, Dept Microbiol Tumour & Cell Biol, Stockholm, Sweden
Francois Bompart - Sanofi Aventis, Direct Acces Med Access Med, Gentilly, France
Maryline Bonnet - Epictr, Geneva, Switzerland
Steffen Borrmann - Wellcome Trust
Teun Bousema - London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Infect & Immun, London WC1, England
Philippe Brasseur - IRD, Dakar, Senegal
Hasifa Bukirwa - Uganda Malaria Surveillance Project, Kampala, Uganda
Francesco Checchi - Epictr, Paris, France
Prabin Dahal - WorldWide Antimalarial Resistance Network WWARN, Oxford, England
Umberto D'Alessandro - Inst Trop Med, Unit Malariol, B-2000 Antwerp, Belgium
Meghna Desai - Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA USA
Alassane Dicko - University of Bamako
Abdoulaye A. Djimde - University of Bamako
Grant Dorsey - Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
Ogobara K. Doumbo - University of Bamako
Chris J. Drakeley - German Ctr Infect Res, Tubingen, Germany
Stephan Duparc - Med Malaria Venture, Geneva, Switzerland
Teferi Eshetu - Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Hosp Clin, Barcelona, Spain
Emmanuelle Espie - Epictr, Paris, France
Jean-Francois Etard - Epictr, Paris, France
Abul M. Faiz - Mahidol Univ, Fac Trop Med, Bangkok, Thailand
Catherine O. Falade - Univ Ibadan, Coll Med, Dept Pharmacol & Therapeut, Ibadan, Nigeria
Caterina I. Fanello - Mahidol Univ, Fac Trop Med, Mahidol Oxford Res Unit, Bangkok, Thailand
Jean-Francois Faucher - IRD, Mother & Child Hlth Trop Res Unit, Paris, France
Babacar Faye - Univ Cheikh Anta Diop, Dept Parasitol & Mycol, Fac Med, Dakar, Senegal
Oumar Faye - Univ Cheikh Anta Diop, Dept Parasitol & Mycol, Fac Med, Dakar, Senegal
Scott Filler - Global Fund Fight AIDS TB & Malaria, Geneva, Switzerland
Jennifer A. Flegg - WorldWide Antimalarial Resistance Network WWARN, Oxford, England
Bakary Fofana - University of Bamako
Carole Fogg - Univ Portsmouth, Portsmouth Hosp NHS Trust, Portsmouth, Hants, England
Nahla B. Gadalla - London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Infect & Immun, London WC1, England
Oumar Gaye - Univ Cheikh Anta Diop, Dept Parasitol & Mycol, Fac Med, Dakar, Senegal
Blaise Genton - Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland
Peter W. Gething - University of Oxford
Jose P. Gil - Karolinska Inst, Pharmacogenet Sect, Drug Resistance Unit, Dept Physiol & Pharmacol, Stockholm, Sweden
Raquel Gonzalez - Ctr Invest Saude Manhica, Manhica, Mozambique
Francesco Grandesso - Epictr, Paris, France
Bryan Greenhouse - Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
Brian Greenwood - London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Dis Control, London WC1, England
Anastasia Grivoyannis - Univ Washington, Div Emergency Med, Seattle, WA 98195 USA
Philippe J. Guerin - WorldWide Antimalarial Resistance Network WWARN, Oxford, England
Jean-Paul Guthmann - Inst Veille Sanit, Dept Malad Infect, St Maurice, France
Kamal Hamed - Novartis Pharmaceut, E Hanover, NJ USA
Sally Hamour - Royal Free Hosp, UCL Ctr Nephrol, London NW3 2QG, England
Simon I. Hay - Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
Eva Maria Hodel - Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland
Georgina S. Humphreys - WorldWide Antimalarial Resistance Network WWARN, Oxford, England
Jimee Hwang - Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA USA
Maman L. Ibrahim - Ctr Rech Med & Sanit, Niamey, Niger
Daddi Jima - Fed Minist Hlth, Addis Ababa, Ethiopia
Joel J. Jones - Minist Hlth & Social Welf, Natl Malaria Control Programme, Monrovia, Liberia
Vincent Jullien - Univ Paris 05, AP HP, Paris, France
Elizabeth Juma - Kenya Govt Med Res Ctr, Nairobi, Kenya
Patrick S. Kachur - Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA USA
Piet A. Kager - Univ Amsterdam, Acad Med Ctr, Ctr Infect & Immun Amsterdam CINIMA, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands
Erasmus Kamugisha - Catholic Univ Hlth & Allied Sci, Mwanza, Tanzania
Moses R. Kamya - Makerere Univ, Coll Hlth Sci, Kampala, Uganda
Corine Karema - Minist Hlth, Malaria & Other Parasit Dis Div RBC, Kigali, Rwanda
Kassoum Kayentao - Univ Bamako, Fac Med Pharm & Dent, Malaria Res & Training Ctr, Bamako, Mali
Jean-Rene Kiechel - Drugs Neglected Dis initiat, Geneva, Switzerland
Fred Kironde - Makerere Univ, Dept Biochem, Kampala, Uganda
Poul-Erik Kofoed - Projecto Saude Bandim, Bissau, Guinea Bissau
Peter G. Kremsner - University of Tübingen
Sanjeev Krishna - Univ London, Inst Infect & Immun, London, England
Valerie Lameyre - Sanofi Aventis, Direct Acces Med Access Med, Gentilly, France
Bertrand Lell - Univ Tubingen, Inst Trop Med, Tubingen, Germany
Angeles Lima - Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
Michael Makanga - European & Dev Countries Clin Trials Partnership, Cape Town, South Africa
ElFatih M. Malik - Fed Minist Hlth, Khartoum, Sudan
Kevin Marsh - Wellcome Trust
Andreas Martensson - Karolinska Inst, Dept Microbiol Tumour & Cell Biol, Stockholm, Sweden
Achille Massougbodji - Univ Abomey Calavi, FSS, CERPAGE, Cotonou, Benin
Herve Menan - Univ Cocody, Fac Pharm, Dept Parasitol, Abidjan, Cote Ivoire
Didier Menard - Inst Pasteur Cambodia, Malaria Mol Epidemiol Unit, Phnom Penh, Cambodia
Clara Menendez - Ctr Invest Saude Manhica, Manhica, Mozambique
Petra F. Mens - Univ Amsterdam, Acad Med Ctr, Ctr Infect & Immun Amsterdam CINIMA, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands
Martin Meremikwu - Univ Calabar, Dept Paediat, Calabar, Nigeria
Clarissa Moreira - WorldWide Antimalarial Resistance Network WWARN, Oxford, England
Carolyn Nabasumba - Epictr, Paris, France
Michael Nambozi - Trop Dis Res Ctr, Ndola, Zambia
Jean-Louis Ndiaye - Univ Cheikh Anta Diop, Dept Parasitol & Mycol, Fac Med, Dakar, Senegal
Billy E. Ngasala - Muhimbili Univ Hlth & Allied Sci, Dept Parasitol, Dar Es Salaam, Tanzania
Frederic Nikiema - Inst Rech Sci Sante, Bobo Dioulasso, Burkina Faso
Christian Nsanzabana - WorldWide Antimalarial Resistance Network WWARN, Oxford, England
Francine Ntoumi - University of Tübingen
Mary Oguike - London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Infect & Immun, London WC1, England
Bernhards R. Ogutu - United States Army Med Res Unit, Kenya Med Res Inst, Kisumu, Kenya
Piero Olliaro - Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England
Sabah A. Omar - Kenya Govt Med Res Ctr, Ctr Biotechnol Res & Dev, Nairobi, Kenya
Jean-Bosco Ouedraogo - Ctr Muraz, Bobo Dioulasso, Burkina Faso
Seth Owusu-Agyei - Kintampo Hlth Res Ctr, Kintampo, Ghana
Louis K. Penali - WorldWide Antimalarial Resistance Network WWARN W, Dakar, Senegal
Mbaye Pene - Univ Cheikh Anta Diop, Dept Parasitol & Mycol, Fac Med, Dakar, Senegal
Judy Peshu - Wellcome Trust Res Programme, Kenya Med Res Inst, Kilifi, Kenya
Patrice Piola - Inst Pasteur Madagascar, Epidemiol Unit, Antananarivo, Madagascar
Christopher V. Plowe - Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA
Zul Premji - Muhimbili Univ Hlth & Allied Sci, Dept Parasitol, Dar Es Salaam, Tanzania
Ric N. Price - WorldWide Antimalarial Resistance Network WWARN, Oxford, England
Milijaona Randrianarivelojosia - Inst Pasteur Madagascar, Malaria Res Unit, Antananarivo, Madagascar
Lars Rombo - Karolinska Inst, Karolinska Univ Hosp, Infect Dis Unit, Malaria Res Lab,Dept Med, Stockholm, Sweden
Cally Roper - London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Pathogen Mol Biol, London WC1, England
Philip J. Rosenthal - Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
Issaka Sagara - Univ Bamako, Fac Med Pharm & Dent, Malaria Res & Training Ctr, Bamako, Mali
Albert Same-Ekobo - Ctr Hosp Univ Yaounde, Fac Med & Sci Biomed, Yaounde, Cameroon
Patrick Sawa - Int Ctr Insect Physiol & Ecol, Human Hlth Div, Mbita, Kenya
Henk D. F. H. Schallig - KIT Biomed Res, Royal Trop Inst, Amsterdam, Netherlands
Birgit Schramm - Epictr, Paris, France
Amadou Seck - WorldWide Antimalarial Resistance Network WWARN W, Dakar, Senegal
Seif A. Shekalaghe - Ifakara Hlth Inst, Dar Es Salaam, Tanzania
Carol H. Sibley - WorldWide Antimalarial Resistance Network WWARN, Oxford, England
Vronique Sinou - Aix Marseille Univ, Fac Pharm, UMR MD3, Marseille, France
Sodiomon B. Sirima - CNRFP, Ouagadougou, Burkina Faso
Fabrice A. Som - Inst Rech Sci Sante, Bobo Dioulasso, Burkina Faso
Doudou Sow - Univ Cheikh Anta Diop, Dept Parasitol & Mycol, Fac Med, Dakar, Senegal
Sarah G. Staedke - Infect Dis Res Collaborat, Kampala, Uganda
Kasia Stepniewska - WorldWide Antimalarial Resistance Network WWARN, Oxford, England
Colin J. Sutherland - London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Infect & Immun, London WC1, England
Todd D. Swarthout - Med Sans Frontieres, London, England
Khadime Sylla - Univ Cheikh Anta Diop, Dept Parasitol & Mycol, Fac Med, Dakar, Senegal
Ambrose O. Talisuna - East Africa Reg Ctr, WorldWide Antimalarial Resistance Network WWARN, Nairobi, Kenya
Walter R. J. Taylor - UNICEF UNDP World Bank WHO Special Programme Res, Geneva, Switzerland
Emmanuel A. Temu - MENTOR Initiat, Crawley, England
Julie I. Thwing - Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA USA
Roger C. K. Tine - Univ Cheikh Anta Diop, Dept Parasitol & Mycol, Fac Med, Dakar, Senegal
Halidou Tinto - Ctr Muraz, Bobo Dioulasso, Burkina Faso
Silva Tommasini - Sigma Tau Ind Farmaceut Riunite SpA, Rome, Italy
Offianan A. Toure - Inst Pasteur Cote Ivoire, Malariol Dept, Abidjan, Cote Ivoire
Johan Ursing - Projecto Saude Bandim, Bissau, Guinea Bissau
Michel T. Vaillant - CRP Sante, Ctr Hlth Studies, Methodol & Stat Unit, Luxembourg, Luxembourg
Giovanni Valentini - Sigma Tau Ind Farmaceut Riunite SpA, Rome, Italy
Ingrid Van den Broek - Med Sans Frontieres, London, England
Michele Van Vugt - Univ Amsterdam, Acad Med Ctr, Ctr Trop Med & Travel Med, Div Infect Dis, NL-1012 WX Amsterdam, Netherlands
Stephen A. Ward - Univ Liverpool, Liverpool Sch Trop Med, Dept Parasitol, Liverpool L3 5QA, Merseyside, England
Peter A. Winstanley - Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England
William Yavo - Univ Cocody, Fac Pharmaceut & Biol Sci, Dept Parasitol & Mycol, Abidjan, Cote Ivoire
Adoke Yeka - Uganda Malaria Surveillance Project, Kampala, Uganda
Yah M. Zolia - Minist Hlth & Social Welf, Natl Malaria Control Programme, Monrovia, Liberia
Issaka Zongo - Inst Rech Sci Sante, Bobo Dioulasso, Burkina Faso
WWARN Artemisinin Based
Détails de publication: BMC medicine, Vol.13(1), pp.212-16
Éditeur: Springer Nature
Nombre de pages: 16
Note de subvention: Bill AMP; Melinda Gates Foundation; CGIAR
Identifiants: 99148656009311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article