Clade Ib Mpox in the Democratic Republic of the Congo (DRC): Clinical and Virological Report of the First Case in Kinshasa, the Capital City

Franck Kasongo-Mulenda; Sylvie Lundi-Kizela; Sabrina Kalonji-Tshilomba; Deluxe Nsambayi-Lukusa; Mohesa Iteke; Richard Nkwembe-Mpileng; Abraham Muswibwe; Meris Matondo-Kuamfumu; Anguy Makaka; Junior Bulabula-Penge; Servet Kinbonza; Emile Malembi; Cris Kacita; Robert Shongo Lushima; Hélène Grace Otema-Akenda; Emmanuel Lokilo-Lofiko; Elisabeth Pukuta-Simbu; Adrienne Amuri-Aziza; Eddy Kinganda-Lusamaki; Prince Akil-Bandali; Ahidjo Ayouba; Martine Peeters; Eric Delaporte; Jean-Jacques Muyembe-Tamfum; Placide Mbala-Kingebeni; Antoine Nkuba-Ndaye; Véronique Kakiesse-Musumba; Steve Ahuka-Mundeke

doi:10.3390/v17101327

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Clade Ib Mpox in the Democratic Republic of the Congo (DRC): Clinical and Virological Report of the First Case in Kinshasa, the Capital City

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Clade Ib Mpox in the Democratic Republic of the Congo (DRC): Clinical and Virological Report of the First Case in Kinshasa, the Capital City

Franck Kasongo-Mulenda, Sylvie Lundi-Kizela, Sabrina Kalonji-Tshilomba, Deluxe Nsambayi-Lukusa, Mohesa Iteke, Richard Nkwembe-Mpileng, Abraham Muswibwe, Meris Matondo-Kuamfumu, Anguy Makaka, Junior Bulabula-Penge, …

Viruses, Vol.17(10), p.1327

30/09/2025

DOI: https://doi.org/10.3390/v17101327

PMID: 41157598

Résumé

Democratic Republic of the Congo - epidemiology

Disease Outbreaks

Female

Humans

Mpox, Monkeypox - diagnosis

Mpox, Monkeypox - epidemiology

Mpox, Monkeypox - pathology

Mpox, Monkeypox - transmission

Mpox, Monkeypox - virology

Phylogeny

Young Adult

The ongoing mpox clade Ib outbreak was first detected in the eastern Democratic Republic of Congo (DRC) and was associated with sexual transmission. It emerged in Kamituga, a mining city and spread rapidly in surrounding health zones and reached cities like Bukavu and Goma. Here, we describe the clinical, epidemiological, and virological characteristics of the first case of clade Ib in Kinshasa, the capital city in the western DRC. The case involved a young adult woman from Kinshasa who reported unprotected sexual contact with an occasional partner, a former friend, and subsequently developed genital lesions, including vesicles and pustules. These lesions evolved and spread to the entire body, including the limbs, eyes, and soles. The diagnosis was confirmed by PCR and sequencing allowed us to assign clade Ib. We show that infection with mpox clade Ib through sexual transmission can lead to limbal nodular keratoconjunctivitis and focal conjunctivitis as complications. Importantly, these results suggest that clade Ib may have been circulating silently in Kinshasa prior to the official declaration by the Ministry of Health. This also raises concerns about the potential risk of global spread, as is currently being observed. Further studies are needed to investigate whether subsequent outbreaks of clade Ib in Kinshasa may have emerged independently of introductions from Kivu, pointing to a more complex pattern of co-circulation that could define the mpox epidemic in the capital.

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Détails

Titre: Clade Ib Mpox in the Democratic Republic of the Congo (DRC): Clinical and Virological Report of the First Case in Kinshasa, the Capital City
Créateurs - sans rôle: Franck Kasongo-Mulenda - Institut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo
Sylvie Lundi-Kizela - Service de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Sabrina Kalonji-Tshilomba - Service de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Deluxe Nsambayi-Lukusa - Service d'Ophtalmologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Mohesa Iteke - Service de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Richard Nkwembe-Mpileng - Service de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Abraham Muswibwe - Service de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Meris Matondo-Kuamfumu - Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Anguy Makaka - Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Junior Bulabula-Penge - Département de Biologie Médicale, Université Protestante au Congo, Kinshasa P.O. Box 4745, Democratic Republic of the Congo
Servet Kinbonza - Institut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo
Emile Malembi - Hemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa P.O. Box 3088, Democratic Republic of the Congo
Cris Kacita - Hemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa P.O. Box 3088, Democratic Republic of the Congo
Robert Shongo Lushima - Hemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa P.O. Box 3088, Democratic Republic of the Congo
Hélène Grace Otema-Akenda - Hemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa P.O. Box 3088, Democratic Republic of the Congo
Emmanuel Lokilo-Lofiko - Institut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo
Elisabeth Pukuta-Simbu - Institut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo
Adrienne Amuri-Aziza - Institut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo
Eddy Kinganda-Lusamaki - TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier (UM), Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), 34090 Montpellier, France
Prince Akil-Bandali - Institut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo
Ahidjo Ayouba - TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier (UM), Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), 34090 Montpellier, France
Martine Peeters - Université de Montpellier
Eric Delaporte - Université de Montpellier
Jean-Jacques Muyembe-Tamfum - Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Placide Mbala-Kingebeni - Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Antoine Nkuba-Ndaye - TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier (UM), Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), 34090 Montpellier, France
Véronique Kakiesse-Musumba - Service de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Steve Ahuka-Mundeke - Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo
Détails de publication: Viruses, Vol.17(10), p.1327
Identifiants: 99148935709311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article