Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study

David Luque-Paz; Pierre Tattevin; Paul Loubet; François Bénézit; Vincent Thibault; Fabrice Lainé; Philippe Vanhems; Selilah Amour; Bruno Lina; Xavier Duval; Anne-Sophie L’honneur; Nadhira Fidouh; Christine Vallejo; Sophie Alain; Florence Galtier; Vincent Foulongne; Gisèle Lagathu; Nezha Lenzi; Zineb Lesieur; Odile Launay; Stéphane Jouneau; P. Loulergue; S. Momcilovic; J. Mira; N. Marin; J. Charpentier; A. Regent; R. Kanaan; F. Dumas; B. Doumenc; M. Lachatre; T. Szwebel; J. Kansao; Y. Costa; J. Alexandra; H. Becheur; K. Belghalem; J. Bernard; A. Bleibtreu; M. Boisseau; R. Bories; O. Brugiere; F. Brunet; C. Burdet; E. Casalino; M. Caseris; C. Chansiaux; M. Chauchard; P. Chavance; C. Choquet; A. Cloppet-Fontaine; L. Colosi; B. Couset; B. Crestani; F. Crocket; A. Debit; K Delanoe; V. Descamps; P. Dieude; A. Dossier; N. Douron; E. Dupeyrat; N. Emeyrat; C. Fernet; T. Goulenok; S. Harent; R. Jouenne; A. Justet; A. Leleu; I. Lerat; M. Lilamand; H. Mal; A. Marceau; A.-C. Metivier; K. Oplelatora; T. Papo; A.-L. Pelletier; L. Pereira; P. Pradere; R Prommier; P. Ralainnazava; M. Ranaivoision; A. Raynaud-Simon; C. Rioux; K. Sacre; V. Verry; V. Vuong; Y. Yazdapanah; N. Houhou; P. Géraud; V. Driss; V. Maugueret; L. Crantelle; C. Agostini; M. Ray; F. Letois; T. Mura; C. Serrand; S. Noslier; A. Giordano; H. Chevassus; E. Nyiramigisha; C. Merle; Arnaud Bourdin; A. Konaté; X. Capdevilla; G. Du Cailar; A. Terminet; H. Blain; M. Leglise; A. Le Quellec; P. Corne; L. Landreau; K. Klouche; A. Bourgeois; M. Sebbane; G. Mourad; H. Leray; D. Postil; S. Alcolea; E. Couve-Deacon; S. Rogez; L. Argaud; M. Cour; R. Hernu; M. Simon; T. Baudry; K. Tazarourte; C. Bui-Xuan; J. Fattoum; M. Valette; S. Rochas; S. Cochennec; E. Thébault; M. Revest; M. Sébillotte; A. Le Bot; M. Baldeyrou; S. Patrat-Delon; M. Cailleaux; C. Pronier

doi:10.1038/s41598-022-08089-0

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Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study

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Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study

David Luque-Paz, Pierre Tattevin, Paul Loubet, François Bénézit, Vincent Thibault, Fabrice Lainé, Philippe Vanhems, Selilah Amour, Bruno Lina, Xavier Duval, …

Scientific Reports, Vol.12(1)

10/03/2022

DOI: https://doi.org/10.1038/s41598-022-08089-0

PMID: 35273311

Abstract

Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis of the FLUVAC cohort, a multicenter prospective cohort study of adults hospitalized with influenza-like illness (ILI) during six consecutive influenza seasons (2012–2018). All patients were tested for respiratory virus infection by multiplex PCR on nasopharyngeal swabs and/or bronchoalveolar lavage. Risk factors were identified by logistic regression analysis. Among the 2658 patients included, 537 (20.2%) were treated with ICS before admission, of whom 282 (52.5%, 282/537) tested positive for at least one respiratory virus. Patients on ICS were more likely to test positive for non-influenza respiratory viruses (25.1% vs. 19.5%, P = 0.004), especially for adenovirus (aOR 2.36, 95% CI 1.18–4.58), and respiratory syncytial virus (aOR 2.08, 95% CI 1.39–3.09). Complications were reported in 55.9% of patients on ICS (300/537), primarily pneumonia (171/535, 32%). Among patients on chronic ICS who tested positive for respiratory virus, 14.2% (40/282) were admitted to intensive care unit, and in-hospital mortality rate was 2.8% (8/282). Chronic use of ICS is associated with an increased risk of adenovirus or RSV infections in patients admitted for ILI.

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Title: Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study
Creators - without role: David Luque-Paz - Hôpital Pontchaillou
Pierre Tattevin - Centre Hospitalier Universitaire de Rennes
Paul Loubet - Université de Montpellier
François Bénézit - Centre Hospitalier Universitaire de Rennes
Vincent Thibault - Hôpital Pontchaillou
Fabrice Lainé - CIC Rennes
Philippe Vanhems - Hospices Civils de Lyon
Selilah Amour - Hospices Civils de Lyon
Bruno Lina - Hôpital de la Croix-Rousse
Xavier Duval - Hôpital Bichat-Claude-Bernard
Anne-Sophie L’honneur - Hôpital Cochin
Nadhira Fidouh - Hôpital Bichat-Claude-Bernard
Christine Vallejo - Inserm
Sophie Alain - Centre Hospitalier Universitaire de Limoges
Florence Galtier - Hôpital Saint Eloi
Vincent Foulongne - Hôpital Saint Eloi
Gisèle Lagathu - Hôpital Pontchaillou
Nezha Lenzi - Inserm
Zineb Lesieur - Inserm
Odile Launay - French Clinical Research Infrastructure Network
Stéphane Jouneau - École des Hautes Études en Santé Publique
P. Loulergue - Hôpital Cochin
S. Momcilovic - Hôpital Cochin
J. Mira - Hôpital Cochin
N. Marin - Hôpital Cochin
J. Charpentier - Hôpital Cochin
A. Regent - Hôpital Cochin
R. Kanaan - Hôpital Cochin
F. Dumas - Hôpital Cochin
B. Doumenc - Hôpital Cochin
M. Lachatre - Hôpital Cochin
T. Szwebel - Hôpital Cochin
J. Kansao - Hôpital Cochin
Y. Costa
J. Alexandra - Hôpital Bichat-Claude-Bernard
H. Becheur - Hôpital Bichat-Claude-Bernard
K. Belghalem - Hôpital Bichat-Claude-Bernard
J. Bernard - Hôpital Bichat-Claude-Bernard
A. Bleibtreu - Hôpital Bichat-Claude-Bernard
M. Boisseau - Hôpital Bichat-Claude-Bernard
R. Bories - Hôpital Bichat-Claude-Bernard
O. Brugiere - Hôpital Bichat-Claude-Bernard
F. Brunet - Hôpital Bichat-Claude-Bernard
C. Burdet - Hôpital Bichat-Claude-Bernard
E. Casalino - Hôpital Bichat-Claude-Bernard
M. Caseris - Hôpital Bichat-Claude-Bernard
C. Chansiaux - Hôpital Bichat-Claude-Bernard
M. Chauchard - Hôpital Bichat-Claude-Bernard
P. Chavance - Hôpital Bichat-Claude-Bernard
C. Choquet - Hôpital Bichat-Claude-Bernard
A. Cloppet-Fontaine - Hôpital Bichat-Claude-Bernard
L. Colosi - Hôpital Bichat-Claude-Bernard
B. Couset - Hôpital Bichat-Claude-Bernard
B. Crestani - Hôpital Bichat-Claude-Bernard
F. Crocket - Hôpital Bichat-Claude-Bernard
A. Debit - Hôpital Bichat-Claude-Bernard
K Delanoe
V. Descamps - Hôpital Bichat-Claude-Bernard
P. Dieude - Hôpital Bichat-Claude-Bernard
A. Dossier - Hôpital Bichat-Claude-Bernard
N. Douron - Hôpital Bichat-Claude-Bernard
E. Dupeyrat - Hôpital Bichat-Claude-Bernard
N. Emeyrat - Hôpital Bichat-Claude-Bernard
C. Fernet - Hôpital Bichat-Claude-Bernard
T. Goulenok - Hôpital Bichat-Claude-Bernard
S. Harent - Hôpital Bichat-Claude-Bernard
R. Jouenne - Hôpital Bichat-Claude-Bernard
A. Justet - Hôpital Bichat-Claude-Bernard
A. Leleu - Hôpital Bichat-Claude-Bernard
I. Lerat - Hôpital Bichat-Claude-Bernard
M. Lilamand - Hôpital Bichat-Claude-Bernard
H. Mal - Hôpital Bichat-Claude-Bernard
A. Marceau - Hôpital Bichat-Claude-Bernard
A.-C. Metivier - Hôpital Bichat-Claude-Bernard
K. Oplelatora - Hôpital Bichat-Claude-Bernard
T. Papo - Hôpital Bichat-Claude-Bernard
A.-L. Pelletier
L. Pereira - Hôpital Bichat-Claude-Bernard
P. Pradere - Hôpital Bichat-Claude-Bernard
R Prommier
P. Ralainnazava - Hôpital Bichat-Claude-Bernard
M. Ranaivoision - Hôpital Bichat-Claude-Bernard
A. Raynaud-Simon - Hôpital Bichat-Claude-Bernard
C. Rioux - Hôpital Bichat-Claude-Bernard
K. Sacre - Hôpital Bichat-Claude-Bernard
V. Verry - Hôpital Bichat-Claude-Bernard
V. Vuong - Hôpital Bichat-Claude-Bernard
Y. Yazdapanah - Hôpital Bichat-Claude-Bernard
N. Houhou - Hôpital Bichat-Claude-Bernard
P. Géraud - Centre Hospitalier Universitaire de Montpellier
V. Driss - Centre Hospitalier Universitaire de Montpellier
V. Maugueret - Centre Hospitalier Universitaire de Montpellier
L. Crantelle - Centre Hospitalier Universitaire de Montpellier
C. Agostini
M. Ray - Hôpital Bichat-Claude-Bernard
F. Letois - Centre Hospitalier Universitaire de Montpellier
T. Mura - Centre Hospitalier Universitaire de Montpellier
C. Serrand - Centre Hospitalier Universitaire de Montpellier
S. Noslier - Centre Hospitalier Universitaire de Montpellier
A. Giordano - Centre Hospitalier Universitaire de Montpellier
H. Chevassus - Centre Hospitalier Universitaire de Montpellier
E. Nyiramigisha - Centre Hospitalier Universitaire de Montpellier
C. Merle - Centre Hospitalier Universitaire de Montpellier
Arnaud Bourdin - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
A. Konaté - Centre Hospitalier Universitaire de Montpellier
X. Capdevilla - Centre Hospitalier Universitaire de Montpellier
G. Du Cailar - Centre Hospitalier Universitaire de Montpellier
A. Terminet - Centre Hospitalier Universitaire de Montpellier
H. Blain - Centre Hospitalier Universitaire de Montpellier
M. Leglise - Centre Hospitalier Universitaire de Montpellier
A. Le Quellec - Centre Hospitalier Universitaire de Montpellier
P. Corne - Centre Hospitalier Universitaire de Montpellier
L. Landreau - Centre Hospitalier Universitaire de Montpellier
K. Klouche - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
A. Bourgeois - Centre Hospitalier Universitaire de Montpellier
M. Sebbane - Centre Hospitalier Universitaire de Montpellier
G. Mourad - Centre Hospitalier Universitaire de Montpellier
H. Leray - Centre Hospitalier Universitaire de Montpellier
D. Postil
S. Alcolea
E. Couve-Deacon
S. Rogez
L. Argaud - Hospices Civils de Lyon
M. Cour - Hospices Civils de Lyon
R. Hernu - Hospices Civils de Lyon
M. Simon - Hospices Civils de Lyon
T. Baudry - Hospices Civils de Lyon
K. Tazarourte - Hospices Civils de Lyon
C. Bui-Xuan - Hospices Civils de Lyon
J. Fattoum - Hospices Civils de Lyon
M. Valette - Hospices Civils de Lyon
S. Rochas - Hôpital Pontchaillou
S. Cochennec - Hôpital Pontchaillou
E. Thébault - Hôpital Pontchaillou
M. Revest - Hôpital Pontchaillou
M. Sébillotte - Hôpital Pontchaillou
A. Le Bot - Hôpital Pontchaillou
M. Baldeyrou - Hôpital Pontchaillou
S. Patrat-Delon - Hôpital Pontchaillou
M. Cailleaux - Hôpital Pontchaillou
C. Pronier - Hôpital Pontchaillou
Publication Details: Scientific Reports, Vol.12(1)
Grant note: This work was not funded. The study sites received funding from Sanofi Pasteur and MSD for the FLUVAC study. Vaccine producers had no role in the study design, data analysis, decision to publish or preparation of the manuscript.
Identifiers: 9933729409311
Academic Unit: Biocommunication en Cardio-Métabolique - BC2M; Virulence Bacterienne et Infections Chroniques - VBIC; Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Language: English
Resource Type: Journal article
Local Fields: hal-03607627