Chromatin-bound MDM2, a new player in metabolism

Romain Riscal; Laurent Le Cam; Laetitia K. Linares

doi:10.1080/23723556.2016.1210560

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Chromatin-bound MDM2, a new player in metabolism

Journal article

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Chromatin-bound MDM2, a new player in metabolism

Romain Riscal, Laurent Le Cam and Laetitia K. Linares

Molecular & Cellular Oncology, Vol.3(5)

18/02/2016

DOI: https://doi.org/10.1080/23723556.2016.1210560

PMCID: PMC5068176

PMID: 27857973

Abstract

Cancer

Mdm2

chromatin

metabolism

redox

The oncoprotein MDM2 is recognized as a major negative regulator of the p53 tumor suppressor but growing evidence indicates that its oncogenic activities extend beyond p53. We show that MDM2 is recruited to chromatin independently of p53 to regulate a transcriptional program implicated in amino acid metabolism and redox homeostasis.

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Title: Chromatin-bound MDM2, a new player in metabolism
Creators - without role: Romain Riscal - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Laurent Le Cam - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Laetitia K. Linares - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Publication Details: Molecular & Cellular Oncology, Vol.3(5)
Grant note: This research was supported by grants from the Institut National du Cancer (INCa), the Ligue contre le Cancer (Equipe labelisée 2016), and the INSERM-Avenir program. R.R was supported by a fellowship from the French ministry of research and the ARC foundation.
Identifiers: 9944183709311
Academic Unit: Institut de Recherche en Cancérologie de Montpellier - IRCM
Language: English
Resource Type: Journal article
Local Fields: inserm-02465279