Résumé
1,3-Diol motif is of particular interest due to its prominence within many classes of natural products. In this field, ,-diketo sulfoxides are specially attractive because both syn-and anti-1,3-diols can be prepared from these key compounds by two successive high diastereoselective reductions of both carbonyls. Thus,-carbonyl reduction requires DIBAL-H or the ZnX2/DIBAL-H system. The resulting stereochemistry of the corresponding hydroxyl is fully controlled by the chiral sulfoxide group. Then, the reduction of-carbonyl leads to syn or anti 1,3-diols depending on the hydride reagents employed and the stereoselectivity is directed by the newly formedhydroxylic center. In this paper, emphasis is given to the use of valuable ,-diketo sulfoxides in the total synthesis of selected natural products.