Characterization of rat vertebrae cortical bone microstructures using confocal Raman microscopy combined to tomography and electron microscopy

S.A. Shah; H. Salehi; Vincent Cavaillès; F. Fernandez; Frédéric Cuisinier; Pierre-Yves Collart Dutilleul; Alban Desoutter

doi:10.1016/j.aanat.2023.152162

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Characterization of rat vertebrae cortical bone microstructures using confocal Raman microscopy combined to tomography and electron microscopy

Journal article

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Characterization of rat vertebrae cortical bone microstructures using confocal Raman microscopy combined to tomography and electron microscopy

S.A. Shah, H. Salehi, Vincent Cavaillès, F. Fernandez, Frédéric Cuisinier, Pierre-Yves Collart Dutilleul and Alban Desoutter

Annals of Anatomy, Vol.250

10/2023

DOI: https://doi.org/10.1016/j.aanat.2023.152162

PMID: 37774934

Abstract

High resolution micro tomography

Lamellar bone

Mineral density

Rat vertebra

Confocal Raman microscopy

Cortical bone structure

Haversian canals

Rats

Animals

X-Ray Microtomography

Bone and Bones

Cortical Bone

Spine

Microscopy, Electron, Scanning

The rat vertebrae is a good model to study bone regeneration after implantation of biomaterials used to treat bone loss, a major problem in oral and dental surgery. However, the precise characterization of bone microstructures in the rat vertebrae has not been reported. Therefore, the aim of this study was to achieve the complete analysis of such bone, at different scales, in order to have a clear model of healthy bone for comparison with regenerated bone.

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Title: Characterization of rat vertebrae cortical bone microstructures using confocal Raman microscopy combined to tomography and electron microscopy
Creators - without role: S.A. Shah - Université de Montpellier, Laboratoire Bioingénierie et Nanosciences - LBN
H. Salehi - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Vincent Cavaillès - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
F. Fernandez - Université de Montpellier
Frédéric Cuisinier - Université de Montpellier, Laboratoire Bioingénierie et Nanosciences - LBN
Pierre-Yves Collart Dutilleul - Université de Montpellier, Laboratoire Bioingénierie et Nanosciences - LBN
Alban Desoutter - Université de Montpellier, Laboratoire Bioingénierie et Nanosciences - LBN
Publication Details: Annals of Anatomy, Vol.250
Grant note: Authors thank Renaud Lebrun (Institut des Sciences de l’Evolution deMontpellier – ISEM, Univ. Montpellier, CNRS) for his assistance inmicrotomography data acquisition. 3D data acquisitions were per-formed using the micro-CT facilities of the MRI platform member of thenational infrastructure France-BioImaging supported by the FrenchNational Research Agency (ANR-10-INBS-04, " Investments for thefuture "), and of the Labex CEMEB (ANR-10-LABX-0004) and NUMEV(ANR-10-LABX-0020). Thanks to Maxime Bedez for his expertise in backscattered mode of scanning electron microscopy on bone.
Identifiers: 9945071909311
Academic Unit: Institut de Recherche en Cancérologie de Montpellier - IRCM; Laboratoire Bioingénierie et Nanosciences - LBN
Language: English
Resource Type: Journal article
Local Fields: hal-04785492