Cerebral perfusion using ASL in patients with COVID-19 and neurological manifestations: A retrospective multicenter observational study

François-Daniel Ardellier; Seyyid Baloglu; Magdalena Sokolska; Vincent Noblet; François Lersy; Olivier Collange; Jean-Christophe Ferré; Adel Maamar; Béatrice Carsin-Nicol; Julie Helms; Maleka Schenck; Antoine Khalil; Augustin Gaudemer; Sophie Caillard; Julien Pottecher; Nicolas Lefèbvre; Pierre-Emmanuel Zorn; Muriel Matthieu; Jean Christophe Brisset; Clotilde Boulay; Véronique Mutschler; Yves Hansmann; Paul-Michel Mertes; Francis Schneider; Samira Fafi-Kremer; Mickael Ohana; Ferhat Meziani; Nicolas Meyer; Tarek Yousry; Mathieu Anheim; François Cotton; Hans Rolf Jäger; Stéphane Kremer; Fabrice Bonneville; Gilles Adam; Guillaume Martin-Blondel; Jérémie Pariente; Thomas Geeraerts; Hélène Oesterlé; Federico Bolognini; Julien Messie; Ghazi Hmeydia; Joseph Benzakoun; Catherine Oppenheim; Jean-Marc Constans; Serge Metanbou; Adrien Heintz; Blanche Bapst; Imen Megdiche; Lavinia Jager; Patrick Nesser; Yannick Talla Mba; Thomas Tourdias; Juliette Coutureau; Céline Hemmert; Philippe Feuerstein; Nathan Sebag; Sophie Carre; Manel Alleg; Claire Lecocq; Emmanuel Schmitt; René Anxionnat; François Zhu; Géraud Forestier; Aymeric Rouchaud; Pierre-Olivier Comby; Frederic Ricolfi; Pierre Thouant; Sylvie Grand; Alexandre Krainik; Isaure de Beaurepaire; Grégoire Bornet; Audrey Lacalm; Patrick Miailhes; Julie Pique; Claire Boutet; Xavier Fabre; Béatrice Claise; Sonia Mirafzal; Laure Calvet; Hubert Desal; Jérome Berge; Grégoire Boulouis; Apolline Kazemi; Nadya Pyatigorskaya; Augustin Lecler; Suzana Saleme; Myriam Edjlali-Goujon; Basile Kerleroux; Jean-Christophe Brisset; Samir Chenaf; SFNR-COVID group

doi:10.1016/j.neurad.2023.01.005

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Cerebral perfusion using ASL in patients with COVID-19 and neurological manifestations: A retrospective multicenter observational study

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Cerebral perfusion using ASL in patients with COVID-19 and neurological manifestations: A retrospective multicenter observational study

François-Daniel Ardellier, Seyyid Baloglu, Magdalena Sokolska, Vincent Noblet, François Lersy, Olivier Collange, Jean-Christophe Ferré, Adel Maamar, Béatrice Carsin-Nicol, Julie Helms, …

Journal of neuroradiology, Vol.50(5), pp.470-481

01/09/2023

DOI: https://doi.org/10.1016/j.neurad.2023.01.005

PMID: 36657613

Résumé

Cerebrovascular circulation

COVID-19

Magnetic resonance imaging

Multicenter study

Neuroimaging

•In a multicentric cohort of 59 patients suffering from severe COVID-19, ASL perfusion was abnormal in 53, hypoperfusion occurred in 48 (with a predominant fronto-temporo-polar pattern), whereas hyperperfusion occurred in 9.•Post-contrast FLAIR leptomeningeal enhancement was the only parameter with a significant association with cerebral perfusion, as it was tightly linked to hyperperfusion.•Frontotemporal hypoperfusion was also found in quantitative subgroup analysis compared to healthy subjects. Cerebral hypoperfusion has been reported in patients with COVID-19 and neurological manifestations in small cohorts. We aimed to systematically assess changes in cerebral perfusion in a cohort of 59 of these patients, with or without abnormalities on morphological MRI sequences. Patients with biologically-confirmed COVID-19 and neurological manifestations undergoing a brain MRI with technically adequate arterial spin labeling (ASL) perfusion were included in this retrospective multicenter study. ASL maps were jointly reviewed by two readers blinded to clinical data. They assessed abnormal perfusion in four regions of interest in each brain hemisphere: frontal lobe, parietal lobe, posterior temporal lobe, and temporal pole extended to the amygdalo-hippocampal complex. Fifty-nine patients (44 men (75%), mean age 61.2 years) were included. Most patients had a severe COVID-19, 57 (97%) needed oxygen therapy and 43 (73%) were hospitalized in intensive care unit at the time of MRI. Morphological brain MRI was abnormal in 44 (75%) patients. ASL perfusion was abnormal in 53 (90%) patients, and particularly in all patients with normal morphological MRI. Hypoperfusion occurred in 48 (81%) patients, mostly in temporal poles (52 (44%)) and frontal lobes (40 (34%)). Hyperperfusion occurred in 9 (15%) patients and was closely associated with post-contrast FLAIR leptomeningeal enhancement (100% [66.4%-100%] of hyperperfusion with enhancement versus 28.6% [16.6%-43.2%] without, p = 0.002). Studied clinical parameters (especially sedation) and other morphological MRI anomalies had no significant impact on perfusion anomalies. Brain ASL perfusion showed hypoperfusion in more than 80% of patients with severe COVID-19, with or without visible lesion on conventional MRI abnormalities.

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Titre: Cerebral perfusion using ASL in patients with COVID-19 and neurological manifestations: A retrospective multicenter observational study
Créateurs - sans rôle: François-Daniel Ardellier - Service D'imagerie 2, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Seyyid Baloglu - Service D'imagerie 2, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Magdalena Sokolska - Department of Medical Physics and Biomedical Engineering, University College London Hospitals NHS Foundation Trust, 235 Euston Road, London NW1 2BU, United Kingdom
Vincent Noblet - Engineering science, computer science and imaging laboratory (ICube), Integrative Multimodal Imaging in Healthcare, UMR 7357, University of Strasbourg-CNRS, Strasbourg, France
François Lersy - Service D'imagerie 2, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Olivier Collange - Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France
Jean-Christophe Ferré - Department of Neuroradiology, CHU Rennes, Rennes, France
Adel Maamar - Medical Intensive Care Unit, CHU Rennes, Rennes, France
Béatrice Carsin-Nicol - Department of Neuroradiology, CHU Rennes, Rennes, France
Julie Helms - Hôpitaux Universitaires de Strasbourg
Maleka Schenck - Service de Médecine Intensive Réanimation, Hôpitaux universitaires de Strasbourg, Hautepierre, Strasbourg, France
Antoine Khalil - Department of Radiology, Assistance Publique–Hôpitaux de Paris (APHP), Denis Diderot University and Medical School, Bichat University Hospital, Paris, France
Augustin Gaudemer - Neuroradiology Unit, Department of Radiology, Assistance Publique-Hôpitaux de Paris (APHP), Bichat University Hospital, Paris, France
Sophie Caillard - Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
Julien Pottecher - Hôpital de Hautepierre, Service d'Anesthésie, Réanimation & Médecine Péri-Opératoire - Université de Strasbourg, Faculté de Médecine, FMTS, EA3072, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Nicolas Lefèbvre - Service de Maladies Infectieuses, NHC, CHU de Strasbourg, Strasbourg, France
Pierre-Emmanuel Zorn - Hôpitaux Universitaires de Strasbourg, UCIEC, Pôle d'Imagerie, Strasbourg, France
Muriel Matthieu - Hôpitaux Universitaires de Strasbourg, UCIEC, Pôle d'Imagerie, Strasbourg, France
Jean Christophe Brisset - Brisset-Li Consulting, Valbonne-Sophia-Antipolis, France
Clotilde Boulay - Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Véronique Mutschler - Service de Neurologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Yves Hansmann - Service de Maladies Infectieuses, NHC, CHU de Strasbourg, Strasbourg, France
Paul-Michel Mertes - Service d'Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France
Francis Schneider - Service de Médecine Intensive Réanimation, Hôpitaux universitaires de Strasbourg, Hautepierre, Strasbourg, France
Samira Fafi-Kremer - Laboratoire de Virologie Médicale, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Mickael Ohana - Hôpitaux Universitaires de Strasbourg
Ferhat Meziani - Hôpitaux Universitaires de Strasbourg
Nicolas Meyer - Service de Santé Publique, GMRC, CHU de Strasbourg, Strasbourg F-67091 , France
Tarek Yousry - Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
Mathieu Anheim - Hôpitaux Universitaires de Strasbourg
François Cotton - MRI center, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France
Hans Rolf Jäger - UCL Queen Square Institute of Neurology
Stéphane Kremer - Service D'imagerie 2, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Fabrice Bonneville - Toulouse University Hospital, Toulouse, France
Gilles Adam - Toulouse University Hospital, Toulouse, France
Guillaume Martin-Blondel - Toulouse University Hospital, Toulouse, France
Jérémie Pariente - Toulouse University Hospital, Toulouse, France
Thomas Geeraerts - Toulouse University Hospital, Toulouse, France
Hélène Oesterlé - Louis Pasteur Hospital, Colmar, France
Federico Bolognini - Louis Pasteur Hospital, Colmar, France
Julien Messie - Louis Pasteur Hospital, Colmar, France
Ghazi Hmeydia - Sainte-Anne Hospital, Paris, France
Joseph Benzakoun - Sainte-Anne Hospital, Paris, France
Catherine Oppenheim - Sainte-Anne Hospital, Paris, France
Jean-Marc Constans - Amiens University Hospital, Amiens, France
Serge Metanbou - Amiens University Hospital, Amiens, France
Adrien Heintz - Amiens University Hospital, Amiens, France
Blanche Bapst - Henri-Mondor University Hospital, Créteil, France
Imen Megdiche - Henri-Mondor University Hospital, Créteil, France
Lavinia Jager - CHIC Unisanté, Forbach, France
Patrick Nesser - CHIC Unisanté, Forbach, France
Yannick Talla Mba - CHIC Unisanté, Forbach, France
Thomas Tourdias - Bordeaux University Hospital, Bordeaux, France
Juliette Coutureau - Bordeaux University Hospital, Bordeaux, France
Céline Hemmert - Emile Muller Hospital, Mulhouse, France
Philippe Feuerstein - Emile Muller Hospital, Mulhouse, France
Nathan Sebag - Emile Muller Hospital, Mulhouse, France
Sophie Carre - Hospital of Haguenau, Haguenau, France
Manel Alleg - Hospital of Haguenau, Haguenau, France
Claire Lecocq - Hospital of Haguenau, Haguenau, France
Emmanuel Schmitt - Nancy University Hospital, Nancy, France
René Anxionnat - Centre Hospitalier Régional et Universitaire de Nancy
François Zhu - Centre Hospitalier Régional et Universitaire de Nancy
Géraud Forestier - Limoges University Hospital, Limoges, France
Aymeric Rouchaud - Limoges University Hospital, Limoges, France
Pierre-Olivier Comby - Dijon University Hospital, Dijon, France
Frederic Ricolfi - Dijon University Hospital, Dijon, France
Pierre Thouant - Dijon University Hospital, Dijon, France
Sylvie Grand - Grenoble Alpes University Hospital, Grenoble, France
Alexandre Krainik - Grenoble Alpes University Hospital, Grenoble, France
Isaure de Beaurepaire - Antony Private Hospital, Antony, France
Grégoire Bornet - Antony Private Hospital, Antony, France
Audrey Lacalm - Hospices Civils de Lyon
Patrick Miailhes - Hospices Civils de Lyon
Julie Pique - Hospices Civils de Lyon
Claire Boutet - Saint-Etienne University Hospital, Saint-Etienne, France
Xavier Fabre - Saint-Etienne University Hospital, Saint-Etienne, France
Béatrice Claise - Clermont-Ferrand University Hospital, Clermont-Ferrand, France
Sonia Mirafzal - Clermont-Ferrand University Hospital, Clermont-Ferrand, France
Laure Calvet - Clermont-Ferrand University Hospital, Clermont-Ferrand, France
Hubert Desal - French Neuroradiological Society (SFNR) Board, France
Jérome Berge - French Neuroradiological Society (SFNR) Board, France
Grégoire Boulouis - French Neuroradiological Society (SFNR) Board, France
Apolline Kazemi - French Neuroradiological Society (SFNR) Board, France
Nadya Pyatigorskaya - French Neuroradiological Society (SFNR) Board, France
Augustin Lecler - French Neuroradiological Society (SFNR) Board, France
Suzana Saleme - French Neuroradiological Society (SFNR) Board, France
Myriam Edjlali-Goujon - French Neuroradiological Society (SFNR) Board, France
Basile Kerleroux - French Neuroradiological Society (SFNR) Board, France
Jean-Christophe Brisset - French Neuroradiological Society (SFNR) Board, France
Samir Chenaf - UCIEC, France
SFNR-COVID group
Détails de publication: Journal of neuroradiology, Vol.50(5), pp.470-481
Éditeur: Elsevier Masson SAS
Nombre de pages: 12
Identifiants: 99149969109311
Unité académique: Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Langue: English
Type de ressource: Journal article