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Carbonic anhydrase inhibitor coated gold nanoparticle selectively inhibit the tumor-associated isoform IX over the cytosolic ubiquitous isozymes I and II.
Journal article   Peer reviewed

Carbonic anhydrase inhibitor coated gold nanoparticle selectively inhibit the tumor-associated isoform IX over the cytosolic ubiquitous isozymes I and II.

Maamar Stiti, Alessandro Cecchi, Marouan Rami, Mohamed Abdaoui, Véronique Barragan-Montero, Andrea Scozzafava, Yannick Guari, Jean-Yves Winum and Claudiu T. Supuran
Journal of the American Chemical Society, Vol.130, pp.16130-16131
2008
DOI: https://doi.org/10.1021/ja805558k

Abstract

Inhibition Inhibitors Metal nanoparticles Peptides and proteins Sulfones
An approach for the synthesis of carbonic anhydrase (CA, EC 4.2.1.1) inhibitor coated gold nanoparticles is reported. This nanomaterial selectively inhibited the tumor-associated isoform CA IX overexpressed in hypoxic cancers over the ubiquitous, cytosolic housekeeping isozymes CA I and II and was membrane impermeant. As CA IX has an extracellular active site, the new nanomaterial which is confined to the extracellular space may be useful for imaging and treatment of hypoxic tumors.
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