Carbon nanotubes in macrophages: Imaging and chemical analysis by X-ray fluorescence microscopy

Cyrill Bussy; Julien Cambedouzou; Sophie Lanone; Emilie Leccia; Vasile Heresanu; Mathieu Pinault; Martine Mayne-I'Hermite; Nathalie Brun; Claudie Mory; Marine Cotte; Jean Doucet; Jorge Boczkowski; Pascale Launoist

doi:10.1021/nl800914m

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Carbon nanotubes in macrophages: Imaging and chemical analysis by X-ray fluorescence microscopy

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Carbon nanotubes in macrophages: Imaging and chemical analysis by X-ray fluorescence microscopy

Cyrill Bussy, Julien Cambedouzou, Sophie Lanone, Emilie Leccia, Vasile Heresanu, Mathieu Pinault, Martine Mayne-I'Hermite, Nathalie Brun, Claudie Mory, Marine Cotte, …

Nano letters, Vol.8(9), pp.2659-2663

01/09/2008

DOI: https://doi.org/10.1021/nl800914m

PMID: 18672943

Résumé

Chemistry

Chemistry, Multidisciplinary

Chemistry, Physical

Materials Science

Materials Science, Multidisciplinary

Nanoscience & Nanotechnology

Physical Sciences

Physics

Physics, Applied

Physics, Condensed Matter

Science & Technology

Science & Technology - Other Topics

Technology

X-ray fluorescence microscopy (mu XRF) is applied for the first time to study macrophages exposed to unpurified and purified single-walled (SW) and multiwalled (MW) carbon nanotubes (CNT). Investigating chemical elemental distributions allows one to (I) image nanotube localization within a cell and (ii) detect chemical modification of the cell after CNT internalization. An excess of calcium is detected for cells exposed to unpurified SWCNT and MWCNT and related toxicological assays are discussed.

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Détails

Titre: Carbon nanotubes in macrophages: Imaging and chemical analysis by X-ray fluorescence microscopy
Créateurs - sans rôle: Cyrill Bussy - Univ Paris Sud, CNRS, Phys Solide Lab, UMR 8502, F-91405 Orsay, France
Julien Cambedouzou - Univ Paris Sud, CNRS, Phys Solide Lab, UMR 8502, F-91405 Orsay, France
Sophie Lanone - Univ Paris 07, INSERM, U700, F-75018 Paris, France
Emilie Leccia - Univ Paris Sud, CNRS, Phys Solide Lab, UMR 8502, F-91405 Orsay, France
Vasile Heresanu - Univ Paris Sud, CNRS, Phys Solide Lab, UMR 8502, F-91405 Orsay, France
Mathieu Pinault - CEA, DSM IRAMIS SPAM, CNRS, URA 2453,Lab Francis Perrin, F-91191 Gif Sur Yvette, France
Martine Mayne-I'Hermite - CEA, DSM IRAMIS SPAM, CNRS, URA 2453,Lab Francis Perrin, F-91191 Gif Sur Yvette, France
Nathalie Brun - Univ Paris Sud, CNRS, Phys Solide Lab, UMR 8502, F-91405 Orsay, France
Claudie Mory - Univ Paris Sud, CNRS, Phys Solide Lab, UMR 8502, F-91405 Orsay, France
Marine Cotte - European Synchrotron Radiat Facil, F-38043 Grenoble, France
Jean Doucet - Univ Paris Sud, CNRS, Phys Solide Lab, UMR 8502, F-91405 Orsay, France
Jorge Boczkowski - Univ Paris 07, INSERM, U700, F-75018 Paris, France
Pascale Launoist - Univ Paris Sud, CNRS, Phys Solide Lab, UMR 8502, F-91405 Orsay, France
Détails de publication: Nano letters, Vol.8(9), pp.2659-2663
Éditeur: Amer Chemical Soc
Nombre de pages: 5
Note de subvention: ESRF CEA MESR; Ministry of Higher Education, Research & Innovation (MESRI) Region Ile-de-France French ANR; Agence Nationale de la Recherche (ANR) C'nano IdF; Region Ile-de-France CNRS; Centre National de la Recherche Scientifique (CNRS) Assistance Publique-Hopitaux de Paris
Identifiants: 99162713009311
Unité académique: Institut Européen des Membranes - IEM
Langue: English
Type de ressource: Journal article