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CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease
Article de revue   Avec comité de lecture

CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease

Effrosini G Panayotopoulou, Dionyssios N Sgouras, Konstantinos S Papadakos, Kalliopi Petraki, Sébastien Breurec, Spyros Michopoulos, Gerassimos Mantzaris, George Papatheodoridis, Andreas Mentis et Athanasios Archimandritis
Journal of clinical microbiology, Vol.48(6), pp.2237-9
01/06/2010
DOI: https://doi.org/10.1128/JCM.00662-10
PMID: 20392907

Résumé

Adult Aged Antigens, Bacterial Bacterial Proteins Bacteriology DNA, Bacterial Female Helicobacter Infections Helicobacter pylori Humans Life Sciences Male Microbiology and Parasitology Middle Aged Molecular Sequence Data Peptic Ulcer Polymorphism, Genetic Sequence Analysis, DNA Severity of Illness Index Virulence Factors
Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).

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