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CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone
Article de revue   Avec comité de lecture

CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone

Suzy Markossian, Romain Guyot, Sabine Richard, Marie Teixeira, Nadine Aguilera, Mathilde Bouchet, Michelina Plateroti, Wenyue Guan, Karine Gauthier, Denise Aubert, …
Thyroid (New York, N.Y.), Vol.28(1), pp.139-150
01/2018
DOI: https://doi.org/10.1089/thy.2017.0389
PMID: 29205102

Résumé

Animals CRISPR-Cas Systems Development Biology Gene Editing Genes, erbA Genetic Loci Genotyping Techniques INDEL Mutation Life Sciences Male Mice Mice, Inbred C57BL Mutation Mutation, Missense Phenotype RNA, Guide Thyroid Hormone Resistance Syndrome Zygote
Resistance to thyroid hormone due to THRA mutations (RTHα) is a recently discovered genetic disease, displaying important variability in its clinical presentation. The mutations alter the function of TRα1, one of the two nuclear receptors for thyroid hormone.

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