COVID-19 pandemic-associated chilblains: more links for SARS-CoV-2 and less evidence for high interferon type I systemic response

Didier Bessis; Sophie Trouillet-Assant; Léo-Paul Secco; Nathalie Bardin; Brigitte Blanc; Véronique Blatière; Christine Chable-Bessia; Christophe Delfour; Céline Girard; Jean-Christophe Richard; Nathalie Gros; Vincent Le-Moing; Nicolas Molinari; Valérie Pallure; Amandine Pisoni; Nadia Raison‐peyron; Elisa Reynaud; Émilie Schwob; Rémi Pescarmona; Quentin Samaran; Marjolaine Willems; Thierry Vincent; Mircea T Sofonea; Alexandre Belot; Edouard Tuaillon

doi:10.1111/bjd.21820

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COVID-19 pandemic-associated chilblains: more links for SARS-CoV-2 and less evidence for high interferon type I systemic response

Journal article

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COVID-19 pandemic-associated chilblains: more links for SARS-CoV-2 and less evidence for high interferon type I systemic response

Didier Bessis, Sophie Trouillet-Assant, Léo-Paul Secco, Nathalie Bardin, Brigitte Blanc, Véronique Blatière, Christine Chable-Bessia, Christophe Delfour, Céline Girard, Jean-Christophe Richard, …

British Journal of Dermatology, Vol.187(6), pp.1032-1035

01/12/2022

DOI: https://doi.org/10.1111/bjd.21820

PMCID: PMC9538550

PMID: 35971922

Abstract

COVID-19*

Chilblains* / diagnosis

Chilblains* / epidemiology

Chilblains* / etiology

Humans

Interferon Type I*

Pandemics

SARS-CoV-2

Since the onset of the SARS‐CoV‐2 pandemic, the direct causative role of the virus in COVID‐19‐associated chilblains (CAC) has remained under question due to the low rate of positivity to SARS‐CoV‐2 nasopharyngeal polymerase chain reaction (PCR) and blood serology.1 Likewise, the suspected pivotal pathogenic role of upregulation of interferon type I (IFN‐I) is mainly indirectly supported by assessment of in situ immune response.2From April 2020 to January 2022, we prospectively assessed children and adults with new‐onset CAC seen in the dermatology, infectious diseases, and adult and paediatric emergency departments, as well as the intensive care unit of the University Hospital of Montpellier. The study was approved by the local institutional review board (ID: 202000442).

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Title: COVID-19 pandemic-associated chilblains: more links for SARS-CoV-2 and less evidence for high interferon type I systemic response
Creators - without role: Didier Bessis - Inserm
Sophie Trouillet-Assant - Hospices Civils de Lyon
Léo-Paul Secco - Centre Hospitalier Régional Universitaire [Montpellier]
Nathalie Bardin - Unité de recherche sur les maladies cardiovasculaires et métaboliques
Brigitte Blanc - Centre Hospitalier Universitaire de Montpellier
Véronique Blatière - Université de Montpellier
Christine Chable-Bessia - Université de Montpellier, Centre d'études des maladies infectieuses et pharmacologie anti-infectieuse - CEMIPAI
Christophe Delfour - Centre Hospitalier Universitaire de Montpellier
Céline Girard - Inserm
Jean-Christophe Richard - Hospices Civils de Lyon
Nathalie Gros - Université de Montpellier, Centre d'études des maladies infectieuses et pharmacologie anti-infectieuse - CEMIPAI
Vincent Le-Moing - Recherches Translationnelles sur le VIH et les Maladies Infectieuses
Nicolas Molinari - Centre Hospitalier Universitaire de Montpellier
Valérie Pallure
Amandine Pisoni - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Nadia Raison‐peyron - Université de Montpellier
Elisa Reynaud - Hospices Civils de Lyon
Émilie Schwob - Université de Montpellier
Rémi Pescarmona - Hospices Civils de Lyon
Quentin Samaran - Université de Montpellier
Marjolaine Willems - Université de Montpellier, Institut des Neurosciences de Montpellier - INM
Thierry Vincent - Centre Hospitalier Universitaire de Montpellier
Mircea T Sofonea - Université de Montpellier, Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Alexandre Belot - Université Claude Bernard Lyon 1
Edouard Tuaillon - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Publication Details: British Journal of Dermatology, Vol.187(6), pp.1032-1035
Identifiers: 9937435709311
Academic Unit: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC; Institut des Neurosciences de Montpellier - INM; Centre d'études des maladies infectieuses et pharmacologie anti-infectieuse - CEMIPAI; Pathogenesis and Control of Chronic and Emerging Infections - PCCEI; Institut Desbrest d Epidemiologie et de Sante Publique - IDESP; Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Language: English
Resource Type: Journal article
Local Fields: hal-03930679