COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

Livio Pagano; Jon Salmanton-García; Francesco Marchesi; Alessandro Busca; Paolo Corradini; Martin Hoenigl; Nikolai Klimko; Philipp Koehler; Antonio Pagliuca; Francesco Passamonti; Luisa Verga; Benjamin Víšek; Osman Ilhan; Gianpaolo Nadali; Barbora Weinbergerová; Raúl Córdoba-Mascuñano; Monia Marchetti; Graham Collins; Francesca Farina; Chiara Cattaneo; Alba Cabirta; Maria Gomes-Silva; Federico Itri; Jaap van Doesum; Marie-Pierre Ledoux; Martin Čerňan; Ozren Jakšić; Rafael Duarte; Gabriele Magliano; Ali Omrani; Nicola Fracchiolla; Austin Kulasekararaj; Toni Valković; Christian Bjørn Poulsen; Marina Machado; Andreas Glenthøj; Igor Stoma; Zdeněk Ráčil; Klára Piukovics; Milan Navrátil; Ziad Emarah; Uluhan Sili; Johan Maertens; Ola Blennow; Rui Bergantim; Carolina García-Vidal; Lucia Prezioso; Anna Guidetti; Maria Ilaria del Principe; Marina Popova; Nick de Jonge; Irati Ormazabal-Vélez; Noemí Fernández; Iker Falces-Romero; Annarosa Cuccaro; Stef Meers; Caterina Buquicchio; Darko Antić; Murtadha Al-Khabori; Ramón García-Sanz; Monika Biernat; Maria Chiara Tisi; Ertan Sal; Laman Rahimli; Natasa Čolović; Martin Schönlein; Maria Calbacho; Carlo Tascini; Carolina Miranda-Castillo; Nina Khanna; Gustavo-Adolfo Méndez; Verena Petzer; Caroline Besson; Rémy Duléry; Sylvain Lamure; Marcio Nucci; Giovanni Zambrotta; Pavel Žák; Guldane Cengiz Seval; Valentina Bonuomo; Jiří Mayer; Alberto López-García; Maria Vittoria Sacchi; Stephen Booth; Fabio Ciceri; Margherita Oberti; Marco Salvini; Macarena Izuzquiza; Raquel Nunes-Rodrigues; Emanuele Ammatuna; Aleš Obr; Raoul Herbrecht; Lucía Núñez-Martín-Buitrago; Valentina Mancini; Hawraa Shwaylia; Mariarita Sciumè; Jenna Essame; Marietta Nygaard; Josip Batinić; Yung Gonzaga; Isabel Regalado-Artamendi; Linda Katharina Karlsson; Maryia Shapetska; Michaela Hanakova; Shaimaa El-Ashwah; Zita Borbényi; Gökçe Melis Çolak; Anna Nordlander; Giulia Dragonetti; Alessio Maria Edoardo Maraglino; Amelia Rinaldi; Cristina de Ramón-Sánchez; Oliver Cornely; Jan Novák

doi:10.1186/s13045-021-01177-0

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COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

Journal article

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COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

Livio Pagano, Jon Salmanton-García, Francesco Marchesi, Alessandro Busca, Paolo Corradini, Martin Hoenigl, Nikolai Klimko, Philipp Koehler, Antonio Pagliuca, Francesco Passamonti, …

Journal of Hematology and Oncology, Vol.14(1)

12/2021

DOI: https://doi.org/10.1186/s13045-021-01177-0

PMCID: PMC8515781

PMID: 34649563

Abstract

COVID-19

EHA

Epidemiology

Hematological malignancies

Pandemic

Adult

Aged

SARS-CoV-2

Young Adult

Aged, 80 and over

Europe

Female

Hematologic Neoplasms

Hospitalization

Humans

Intensive Care Units

Male

Middle Aged

Registries

Risk Factors

Background Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients ( n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March–May 2020) and the second wave (October–December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.

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Title: COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)
Creators - without role: Livio Pagano - Agostino Gemelli University Polyclinic
Jon Salmanton-García - University Hospital Cologne
Francesco Marchesi - Istituti di Ricovero e Cura a Carattere Scientifico
Alessandro Busca - Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
Paolo Corradini - Fondazione IRCCS Istituto Nazionale dei Tumori
Martin Hoenigl - University of California System
Nikolai Klimko - Odessa National I.I.Mechnikov University
Philipp Koehler - University Hospital Cologne
Antonio Pagliuca - King's College Hospital NHS Foundation Trust
Francesco Passamonti - University of Insubria
Luisa Verga - Azienda Ospedaliera San Gerardo
Benjamin Víšek - University Hospital Hradec Králové
Osman Ilhan - Ankara University
Gianpaolo Nadali - University of Verona
Barbora Weinbergerová - Masaryk University
Raúl Córdoba-Mascuñano - Hospital Universitario Fundación Jiménez Díaz
Monia Marchetti - Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
Graham Collins - Churchill Hospital
Francesca Farina - Istituti di Ricovero e Cura a Carattere Scientifico
Chiara Cattaneo - Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Alba Cabirta - Vall d'Hebron Hospital Universitari
Maria Gomes-Silva - IPO Porto
Federico Itri - Ospedale San Luigi Gonzaga
Jaap van Doesum - University Medical Center Groningen
Marie-Pierre Ledoux - Institut de Cancérologie de Strasbourg Europe
Martin Čerňan - University Hospital Olomouc
Ozren Jakšić - University Hospital Dubrava
Rafael Duarte - Hospital Universitario Puerta de Hierro Majadahonda
Gabriele Magliano - Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Ali Omrani - Hamad Medical Corporation
Nicola Fracchiolla - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Austin Kulasekararaj - King's College Hospital
Toni Valković - University of Rijeka
Christian Bjørn Poulsen - Zealand University Hospital
Marina Machado - Hospital General Universitario Gregorio Marañón
Andreas Glenthøj - Rigshospitalet
Igor Stoma - Gomel State Medical University
Zdeněk Ráčil - Institute of Haematology and Blood Transfusion
Klára Piukovics - University of Szeged
Milan Navrátil - University Hospital Ostrava
Ziad Emarah - Mansoura University
Uluhan Sili - Marmara University
Johan Maertens - KU Leuven
Ola Blennow - Karolinska University Hospital
Rui Bergantim - Hospital de São João
Carolina García-Vidal - Hospital Clínic de Barcelona
Lucia Prezioso - Ospedale Maggiore
Anna Guidetti - Fondazione IRCCS Istituto Nazionale dei Tumori
Maria Ilaria del Principe - University of Rome Tor Vergata
Marina Popova - First Pavlov State Medical University of St. Petersburg
Nick de Jonge - Amsterdam University Medical Centers
Irati Ormazabal-Vélez - Complejo Hospitalario de Navarra
Noemí Fernández - Marqués de Valdecilla University Hospital
Iker Falces-Romero - Hospital Universitario La Paz
Annarosa Cuccaro - Azienda Usl Toscana Centro
Stef Meers - AZ Klina
Caterina Buquicchio
Darko Antić - University of Belgrade
Murtadha Al-Khabori - Sultan Qaboos University Hospital
Ramón García-Sanz - Complejo Hospitalario de Salamanca
Monika Biernat - Wroclaw Medical University
Maria Chiara Tisi - Ospedale San Bortolo
Ertan Sal - University Hospital Cologne
Laman Rahimli - University Hospital Cologne
Natasa Čolović - University of Belgrade
Martin Schönlein - University Medical Center Hamburg-Eppendorf
Maria Calbacho - Hospital Universitario 12 De Octubre
Carlo Tascini - Azienda Sanitaria Universitaria Friuli Centrale
Carolina Miranda-Castillo - Universidad Rey Juan Carlos
Nina Khanna - University Hospital of Basel
Gustavo-Adolfo Méndez
Verena Petzer - Innsbruck Medical University
Caroline Besson - Centre Hospitalier de Versailles
Rémy Duléry - Hôpital Saint-Antoine
Sylvain Lamure - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Marcio Nucci - Universidade Federal do Rio de Janeiro
Giovanni Zambrotta - University of Milano-Bicocca
Pavel Žák - Faculty
Guldane Cengiz Seval - Ankara University
Valentina Bonuomo - University of Verona
Jiří Mayer - Masaryk University
Alberto López-García - Hospital Universitario Fundación Jiménez Díaz
Maria Vittoria Sacchi - Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
Stephen Booth - Churchill Hospital
Fabio Ciceri - Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
Margherita Oberti - Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Marco Salvini - University of Insubria
Macarena Izuzquiza - Vall d'Hebron Institute of Oncology
Raquel Nunes-Rodrigues - IPO Porto
Emanuele Ammatuna - University Medical Center Groningen
Aleš Obr - University Hospital Olomouc
Raoul Herbrecht - Institut de Cancérologie Strasbourg
Lucía Núñez-Martín-Buitrago - Hospital Universitario Puerta de Hierro Majadahonda
Valentina Mancini - Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Hawraa Shwaylia - National Center for Cancer Care and Research
Mariarita Sciumè - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Jenna Essame - King's College Hospital
Marietta Nygaard - Zealand University Hospital
Josip Batinić - Croatian Chamber of Economy
Yung Gonzaga - Instituto Nacional do Câncer
Isabel Regalado-Artamendi - Hospital General Universitario Gregorio Marañón
Linda Katharina Karlsson - Rigshospitalet
Maryia Shapetska - Republican Scientific and Practical Center of Neurology and Neurosurgery
Michaela Hanakova - Institute of Haematology and Blood Transfusion
Shaimaa El-Ashwah - Mansoura University
Zita Borbényi - University of Szeged
Gökçe Melis Çolak - Marmara University
Anna Nordlander - Karolinska University Hospital
Giulia Dragonetti - Università Cattolica del Sacro Cuore
Alessio Maria Edoardo Maraglino - Agostino Gemelli University Polyclinic
Amelia Rinaldi - Ospedale Maggiore
Cristina de Ramón-Sánchez - Centro de Investigación del Cáncer
Oliver Cornely - University Hospital Cologne
Jan Novák - University Hospital Kralovske Vinohrady
Publication Details: Journal of Hematology and Oncology, Vol.14(1)
Identifiers: 9938328909311
Academic Unit: Institut de Génétique Moléculaire de Montpellier - IGMM
Language: English
Resource Type: Journal article
Local Fields: hal-03642030