COVID-19 in adult acute myeloid leukemia patients: a long-term followup study from the European Hematology Association survey (EPICOVIDEHA)

Francesco Marchesi; Jon Salmanton-García; Ziad Emarah; Klára Piukovics; Marcio Nucci; Alberto López-García; Zdeněk Ráčil; Francesca Farina; Marina Popova; Sofia Zompi; Ernesta Audisio; Marie-Pierre Ledoux; Luisa Verga; Barbora Weinbergerová; Tomas Szotkovski; Maria Gomes da Silva; Nicola Fracchiolla; Nick de Jonge; Graham Collins; Monia Marchetti; Gabriele Magliano; Carolina García-Vidal; Monika Biernat; Jaap van Doesum; Marina Machado; Fatih Demirkan; Murtadha Al-Khabori; Pavel Žák; Benjamín Víšek; Igor Stoma; Gustavo-Adolfo Méndez; Johan Maertens; Nina Khanna; Ildefonso Espigado; Giulia Dragonetti; Luana Fianchi; Maria Ilaria del Principe; Alba Cabirta; Irati Ormazabal-Vélez; Ozren Jaksic; Caterina Buquicchio; Valentina Bonuomo; Josip Batinić; Ali Omrani; Sylvain Lamure; Olimpia Finizio; Noemí Fernández; Iker Falces-Romero; Ola Blennow; Rui Bergantim; Natasha Ali; Sein Win; Jens van Praet; Maria Chiara Tisi; Ayten Shirinova; Martin Schönlein; Juergen Prattes; Monica Piedimonte; Verena Petzer; Milan Navrátil; Austin Kulasekararaj; Pavel Jindra; Jiří Sramek; Andreas Glenthøj; Rita Fazzi; Cristina de Ramón-Sánchez; Chiara Cattaneo; Maria Calbacho; Nathan Bahr; Shaimaa El-Ashwah; Raul Cordoba; Michaela Hanakova; Giovanni Zambrotta; Mariarita Sciumè; Stephen Booth; Raquel Nunes Rodrigues; Maria Vittoria Sacchi; Nicole García-Poutón; Juan-Alberto Martín-González; Sofya Khostelidi; Stefanie Gräfe; Laman Rahimli; Emanuele Ammatuna; Alessandro Busca; Paolo Corradini; Martin Hoenigl; Nikolai Klimko; Philipp Koehler; Antonio Pagliuca; Francesco Passamonti; Oliver Cornely; Livio Pagano

doi:10.3324/haematol.2022.280847

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COVID-19 in adult acute myeloid leukemia patients: a long-term followup study from the European Hematology Association survey (EPICOVIDEHA)

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COVID-19 in adult acute myeloid leukemia patients: a long-term followup study from the European Hematology Association survey (EPICOVIDEHA)

Francesco Marchesi, Jon Salmanton-García, Ziad Emarah, Klára Piukovics, Marcio Nucci, Alberto López-García, Zdeněk Ráčil, Francesca Farina, Marina Popova, Sofia Zompi, …

Haematologica

12/05/2022

DOI: https://doi.org/10.3324/haematol.2022.280847

Abstract

Patients with acute myeloid leukemia (AML) are at high risk of mortality from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients with COVID-19 diagnosis between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the prior 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with an improved survival when AML treatment could be delayed (80%; p

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Title: COVID-19 in adult acute myeloid leukemia patients: a long-term followup study from the European Hematology Association survey (EPICOVIDEHA)
Creators - without role: Francesco Marchesi - Istituti di Ricovero e Cura a Carattere Scientifico
Jon Salmanton-García - Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
Ziad Emarah - Mansoura University
Klára Piukovics - University of Szeged
Marcio Nucci - Universidade Federal do Rio de Janeiro
Alberto López-García - Hospital Universitario Fundación Jiménez Díaz
Zdeněk Ráčil - Masaryk University
Francesca Farina - IRCCS Ospedale San Raffaele
Marina Popova - First Pavlov State Medical University of St. Petersburg
Sofia Zompi
Ernesta Audisio
Marie-Pierre Ledoux
Luisa Verga - Azienda Ospedaliera San Gerardo
Barbora Weinbergerová - University Hospital Brno
Tomas Szotkovski - University Hospital Olomouc
Maria Gomes da Silva - Instituto Português de Oncologia Francisco Gentil
Nicola Fracchiolla - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Nick de Jonge - Amsterdam University Medical Centers
Graham Collins - Oxford University Hospitals NHS Trust
Monia Marchetti - Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
Gabriele Magliano - Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Carolina García-Vidal - Hospital Clínic de Barcelona
Monika Biernat - Wroclaw Medical University
Jaap van Doesum - University Medical Center Groningen
Marina Machado - Hospital General Universitario Gregorio Marañón
Fatih Demirkan
Murtadha Al-Khabori - Sultan Qaboos University Hospital
Pavel Žák
Benjamín Víšek - University Hospital Hradec Králové
Igor Stoma
Gustavo-Adolfo Méndez
Johan Maertens - KU Leuven
Nina Khanna - University Hospital of Basel
Ildefonso Espigado - Instituto de Biomedicina de Sevilla
Giulia Dragonetti - Agostino Gemelli University Polyclinic
Luana Fianchi - Agostino Gemelli University Polyclinic
Maria Ilaria del Principe - University of Rome Tor Vergata
Alba Cabirta - Vall d'Hebron Hospital Universitari
Irati Ormazabal-Vélez - Complejo Hospitalario de Navarra
Ozren Jaksic - University Hospital Dubrava
Caterina Buquicchio
Valentina Bonuomo - University of Verona
Josip Batinić - University Hospital Centre Zagreb
Ali Omrani - Hamad Medical Corporation
Sylvain Lamure - Université de Montpellier
Olimpia Finizio - Ospedale Antonio Cardarelli
Noemí Fernández - Marqués de Valdecilla University Hospital
Iker Falces-Romero - Hospital Universitario La Paz
Ola Blennow - Karolinska University Hospital
Rui Bergantim
Natasha Ali - Aga Khan University Hospital
Sein Win - University Of Medicine 1 Yangon
Jens van Praet - AZ Sint-Jan
Maria Chiara Tisi - Ospedale San Bortolo
Ayten Shirinova - Azerbaijan Scientific-Research & Design-Prospecting Power Engineering Institute
Martin Schönlein - University Medical Center Hamburg-Eppendorf
Juergen Prattes - Medical University of Graz
Monica Piedimonte - Azienda Ospedaliera Sant'Andrea
Verena Petzer - Innsbruck Medical University
Milan Navrátil - University Hospital Ostrava
Austin Kulasekararaj - King's College Hospital
Pavel Jindra - Pilsen Tools
Jiří Sramek
Andreas Glenthøj - Copenhagen University Hospital
Rita Fazzi - Ospedale Cisanello
Cristina de Ramón-Sánchez - Instituto de Investigación Biomédica de Salamanca
Chiara Cattaneo - Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Maria Calbacho - Hospital Universitario 12 De Octubre
Nathan Bahr - University of Kansas Medical Center
Shaimaa El-Ashwah - Mansoura University
Raul Cordoba - Hospital Universitario Fundación Jiménez Díaz
Michaela Hanakova - Institute of Haematology and Blood Transfusion
Giovanni Zambrotta
Mariarita Sciumè - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Stephen Booth - Oxford University Hospitals NHS Trust
Raquel Nunes Rodrigues - Instituto Português de Oncologia Francisco Gentil
Maria Vittoria Sacchi - Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
Nicole García-Poutón - Hospital Clínic de Barcelona
Juan-Alberto Martín-González - Hospital Universitario Virgen del Rocío
Sofya Khostelidi
Stefanie Gräfe - University Medical Center Hamburg-Eppendorf
Laman Rahimli - Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
Emanuele Ammatuna - University Medical Center Groningen
Alessandro Busca
Paolo Corradini - Fondazione IRCCS Istituto Nazionale dei Tumori
Martin Hoenigl - University of California, San Diego
Nikolai Klimko
Philipp Koehler - University Hospital Cologne
Antonio Pagliuca - King's College Hospital NHS Foundation Trust
Francesco Passamonti - University of Insubria
Oliver Cornely - University Hospital Cologne
Livio Pagano - Agostino Gemelli University Polyclinic
Publication Details: Haematologica
Identifiers: 9944161409311
Academic Unit: Institut de Génétique Moléculaire de Montpellier - IGMM
Language: English
Resource Type: Journal article
Local Fields: hal-03791177