[COVID-19 and organ transplantation, lessons from the national Registry of the Société Francophone de Transplantation]

Sophie Caillard; B. Moulin; S. Fafi-Kremer; M. Hazzan; D. Anglicheau; A. Hertig; J. Tourret; Benoît Barrou; E. Morelon; O. Thaunat; L. Couzi; P. Merville; V. Moal; T. Legris; P.-F. Westeel; M. Jaureguy; Luc Frimat; D. Ducloux; J. Bamoulid; D. Bertrand; M. Tsimaratos; F. Garaix-Gilardo; J. Dumortier; S. Mussot; A. Roux; L. Sebbag; Y. Le Meur; G. Blancho; C. Masset; N. Kamar; H. Francois; E. Rondeau; N. Bouvier; C. Mousson; M. Buchler; P. Gatault; J.-F. Augusto; A. Duveau; C. Vigneau; M.-C. Morin; J. Chemouny; L. Golbin; P. Grimbert; M. Matignon; A. Durrbach; C. Greze; R. Snanoudj; C. Colosio; B. Schvartz; P. Malvezzi; C. Mariat; A. Thierry; Moglie Le Quintrec; A. Sicard; J.P. Rerolle; A.-É. Heng; C. Garrouste; H.V. Coponat; É. Epailly; O. Brugiere; S. Dharancy; É. Salame; F. Saliba

doi:10.1016/j.banm.2022.01.025

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[COVID-19 and organ transplantation, lessons from the national Registry of the Société Francophone de Transplantation]

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[COVID-19 and organ transplantation, lessons from the national Registry of the Société Francophone de Transplantation]

Sophie Caillard, B. Moulin, S. Fafi-Kremer, M. Hazzan, D. Anglicheau, A. Hertig, J. Tourret, Benoît Barrou, E. Morelon, O. Thaunat, …

Bulletin de l'Académie Nationale de Médecine, Vol.206(4), pp.511-517

04/2022

DOI: https://doi.org/10.1016/j.banm.2022.01.025

PMCID: PMC8848542

PMID: 35185155

Abstract

Covid-19

Mortality

Registry

Transplantation

Vaccination

The Covid-19 pandemic hit the transplant world in March 2020. Teams quickly organized themselves to optimize the management of their immunocompromised patients and to progress in the knowledge of this new disease. To do this, a French Registry was set up, listing all solid organ transplant patients who had developed a SARS Cov2 infection. Numerous studies carried out on the basis of these data have enabled us to describe the disease in transplant patients, to characterize its clinical and biological severity factors and to define its prognosis. The mortality of transplant patients hospitalized for Covid-19 is 23% at 60 days and renal insufficiency plays a major role in the poor prognosis in addition to the classic risk factors described in the general population. The advent of vaccination has been a great relief, but transplant patients have developed a poorer vaccine response than immunocompetent subjects, keeping them at risk of severe disease after an adapted vaccination schedule. Specific strategies had to be adopted in this particularly fragile population (increased number of vaccine doses, injection of monoclonal antibodies). The collaboration of the French transplantation centers under the impulse of the Société Francophone de Transplantation allowed us to carry out many collaborative projects, which were of great use for the care of the patients.

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Title: [COVID-19 and organ transplantation, lessons from the national Registry of the Société Francophone de Transplantation]
Creators - without role: Sophie Caillard - Hôpitaux Universitaires de Strasbourg
B. Moulin - Centre Hospitalier Universitaire [Strasbourg]
S. Fafi-Kremer - Institut de Virologie
M. Hazzan - Centre Hospitalier Régional Universitaire [CHU Lille]
D. Anglicheau - Hôpital Necker-Enfants Malades
A. Hertig - Charmo University
J. Tourret - Infection, Anti-microbiens, Modélisation, Evolution
Benoît Barrou - Charmo University
E. Morelon - Hôpital Edouard Herriot
O. Thaunat - Centre International de Recherche en Infectiologie
L. Couzi - Centre Hospitalier Universitaire de Bordeaux
P. Merville - Centre Hospitalier Universitaire de Bordeaux
V. Moal - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
T. Legris - Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM]
P.-F. Westeel - Centre Hospitalier Universitaire Amiens-Picardie
M. Jaureguy - Centre Hospitalier Universitaire Amiens-Picardie
Luc Frimat - Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est
D. Ducloux - Inserm
J. Bamoulid - Inserm
D. Bertrand - Charmo University
M. Tsimaratos - Hôpital de la Timone
F. Garaix-Gilardo - Hôpital de la Timone
J. Dumortier - Hôpital Edouard Herriot
S. Mussot - Hôpital Marie Lannelongue
A. Roux - Hôpital Marie Lannelongue
L. Sebbag - Hôpital Louis Pradel
Y. Le Meur - Hôpital de la Cavale Blanche - CHRU Brest
G. Blancho - Hôpital Hôtel-Dieu [Paris]
C. Masset - Hôpital Hôtel-Dieu [Paris]
N. Kamar - Centre Hospitalier Universitaire de Toulouse
H. Francois - Charmo University
E. Rondeau - Charmo University
N. Bouvier - Charmo University
C. Mousson - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
M. Buchler - Centre Hospitalier Régional Universitaire de Tours
P. Gatault - Centre Hospitalier Régional Universitaire de Tours
J.-F. Augusto - Centre Hospitalier Universitaire d'Angers
A. Duveau - Centre Hospitalier Universitaire d'Angers
C. Vigneau - Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
M.-C. Morin - Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
J. Chemouny - Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
L. Golbin - Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
P. Grimbert - Hôpital Henri Mondor
M. Matignon - Hôpital Henri Mondor
A. Durrbach - Hôpital Henri Mondor
C. Greze - Hôpital Bichat-Claude-Bernard
R. Snanoudj - Hôpital Foch
C. Colosio - Hôpital Maison Blanche
B. Schvartz - Hôpital Maison Blanche
P. Malvezzi - Hôpital la Tronche
C. Mariat - Centre Hospitalier Universitaire de Saint-Étienne
A. Thierry - Bernard
Moglie Le Quintrec - Centre Hospitalier Régional Universitaire [Montpellier]
A. Sicard - Hôpital Pasteur
J.P. Rerolle - Hôpital Dupuytren
A.-É. Heng - Charmo University
C. Garrouste - Charmo University
H.V. Coponat - Centre Hospitalier Universitaire de La Réunion
É. Epailly - Hôpitaux Universitaires de Strasbourg
O. Brugiere - Hôpital Foch
S. Dharancy - Hôpital Claude Huriez
É. Salame - Centre Hospitalier Régional Universitaire de Tours
F. Saliba - Centre Hépato-Biliaire [Hôpital Paul Brousse]
Publication Details: Bulletin de l'Académie Nationale de Médecine, Vol.206(4), pp.511-517
Identifiers: 9934133409311
Academic Unit: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Language: English
Resource Type: Journal article
Local Fields: hal-04998253