CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): 12-month angiographic results of a multicenter study

Laurent Spelle; Denis Herbreteau; Jildaz Caroff; Xavier Barreau; Jean-Christophe Ferré; Jens Fiehler; Anne-Christine Januel; Vincent Costalat; Thomas Liebig; Romain Bourcier; Markus A Möhlenbruch; Joachim Berkefeld; Werner Weber; Cristian Mihalea; Léon Ikka; Augustin Ozanne; Christophe Cognard; Ana Paula Narata; Richard Edwige Bibi; Jean-Yves Gauvrit; Hélène Raoult; Stéphane Velasco; Jan-Hendrik Buhk; Vanessa Chalumeau; Maxim Bester; Hubert Desal; Richard du Mesnil de Rochemont; Georg Bohner; Sebastian Fischer; Sophie Gallas; Alessandra Biondi; Lamiae Grimaldi; Jacques Moret; James Byrne; Laurent Pierot

doi:10.1136/neurintsurg-2022-018749

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CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): 12-month angiographic results of a multicenter study

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CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): 12-month angiographic results of a multicenter study

Laurent Spelle, Denis Herbreteau, Jildaz Caroff, Xavier Barreau, Jean-Christophe Ferré, Jens Fiehler, Anne-Christine Januel, Vincent Costalat, Thomas Liebig, Romain Bourcier, …

Journal of neurointerventional surgery, Vol.15(7), pp.650-654

01/07/2023

DOI: https://doi.org/10.1136/neurintsurg-2022-018749

PMID: 35882550

Résumé

Aneurysm

Angiography

Device

Hemorrhagic stroke

Intervention

Subarachnoid

BackgroundThe CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS) study has shown that the endovascular treatment of ruptured bifurcation aneurysms with the Woven EndoBridge (WEB) is safe and effective and provides protection against rebleeding at 1 month and 1 year. The 12-month angiographic follow-up is an important endpoint of the study.MethodsThe CLARYS study is a prospective multicenter study conducted in 13 European centers. The study enrolled 60 patients with 60 ruptured aneurysms of the anterior and posterior circulation. The study was conducted with an independent assessment of safety outcomes and imaging.ResultsSixty patients with 60 ruptured bifurcation aneurysms to be treated with the WEB were included. Fifty-three aneurysms (88.3%) had a broad base with a dome to neck ratio <2 (mean 1.6). Of these, 46 patients were evaluated by an independent core laboratory with follow-up imaging performed at 12 months or before eventual retreatment. At 1 year, 19/46 aneurysms (41.3%) were completely occluded (Raymond–Roy grade I), 21/46 (45.7%) had a residual neck and 6/46 (13.0%) had residual aneurysm filling. Adequate occlusion was reported in 40/46 (87%) aneurysms. Six patients underwent target aneurysm retreatment.ConclusionsThe CLARYS study has previously shown that the use of the WEB in the endovascular treatment of ruptured bifurcation aneurysms provides effective protection against rebleeding with a good safety profile. The angiographic occlusion rates at 1 year reported here are comparable to those already seen in previous multicenter studies which primarily included unruptured aneurysms.

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Titre: CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS): 12-month angiographic results of a multicenter study
Créateurs - sans rôle: Laurent Spelle - Paris-Saclay University Faculty of Medicine, Le Kremlin-Bicetre, France
Denis Herbreteau - Department of Interventional Neuroradiology, Regional University Hospital, Tours, France
Jildaz Caroff - Assistance Publique - Hopitaux de Paris, Paris, France
Xavier Barreau - Department of Neuroradiology, Pellegrin University Hospital, Bordeaux, France
Jean-Christophe Ferré - Department of Neuroradiology, Regional University Hospital, Rennes, France
Jens Fiehler - Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Anne-Christine Januel - Department of Diagnostic and Therapeutic Neuroradiology, Hôpital Pierre Paul Riquet, Toulouse, France
Vincent Costalat - Hôpital Gui de Chauliac
Thomas Liebig - Ludwig-Maximilians-Universität München
Romain Bourcier - Department of Neuroradiology, Regional University Hospital, Nantes, France
Markus A Möhlenbruch - Department of Neuroradiology, UniversitätsKlinikum Heidelberg, Heidelberg, Germany
Joachim Berkefeld - Institut für Neuroradiologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt am Main, Germany
Werner Weber - Department of Neuroradiology, Ruhr-Universitat Bochum Medizinische Fakultat, Bochum, Germany
Cristian Mihalea - Assistance Publique - Hopitaux de Paris, Paris, France
Léon Ikka - Assistance Publique - Hopitaux de Paris, Paris, France
Augustin Ozanne - Assistance Publique - Hopitaux de Paris, Paris, France
Christophe Cognard - Department of Diagnostic and Therapeutic Neuroradiology, Hôpital Pierre Paul Riquet, Toulouse, France
Ana Paula Narata - Department of Interventional Neuroradiology, Regional University Hospital, Tours, France
Richard Edwige Bibi - Department of Interventional Neuroradiology, Regional University Hospital, Tours, France
Jean-Yves Gauvrit - Department of Neuroradiology, Regional University Hospital, Rennes, France
Hélène Raoult - Department of Neuroradiology, Regional University Hospital, Rennes, France
Stéphane Velasco - Department of Radiology, Regional University Hospital, Poitiers, France
Jan-Hendrik Buhk - Department of Neuroradiology, Asklepios Hospital Group, Hamburg, Germany
Vanessa Chalumeau - Assistance Publique - Hopitaux de Paris, Paris, France
Maxim Bester - Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Hubert Desal - Department of Neuroradiology, Regional University Hospital, Nantes, France
Richard du Mesnil de Rochemont - Institut für Neuroradiologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt am Main, Germany
Georg Bohner - Neuroradiology, Charite Universitatsmedizin, Berlin, Germany
Sebastian Fischer - Department of Neuroradiology, Ruhr-Universitat Bochum Medizinische Fakultat, Bochum, Germany
Sophie Gallas - Assistance Publique - Hopitaux de Paris, Paris, France
Alessandra Biondi - Department of Neuroradiology and Endovascular Therapy, Jean Minjoz University Hospital, Besancon, France
Lamiae Grimaldi - CESP Anti-Infective Evasion and Pharmacoepidemiology Team, Université de Versailles Saint-Quentin-en-Yvelines UFR des Sciences de la Santé Simone Veil, Montigny-Le-Bretonneux, France
Jacques Moret - Paris-Saclay University Faculty of Medicine, Le Kremlin-Bicetre, France
James Byrne - Department of Neuroradiology, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK
Laurent Pierot - Champagne-Ardenne University, Reims, France
Détails de publication: Journal of neurointerventional surgery, Vol.15(7), pp.650-654
Éditeur: BMJ Publishing Group Ltd
Nombre de pages: 5
Identifiants: 99163110509311
Unité académique: Institut de Génomique Fonctionnelle - IGF
Langue: English
Type de ressource: Journal article