Building a new conceptual framework for receptor heteromers

Sergi Ferre; Ruben Baler; Michel Bouvier; Marc G. Caron; Lakshmi A. Devi; Thierry Durroux; Kjell Fuxe; Susan R. George; Jonathan A. Javitch; Martin J. Lohse; Ken Mackie; Graeme Milligan; Kevin D. G. Pfleger; Jean-Philippe Pin; Nora D. Volkow; Maria Waldhoer; Amina S. Woods; Rafael Franco

doi:10.1038/nchembio0309-131

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Building a new conceptual framework for receptor heteromers

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Building a new conceptual framework for receptor heteromers

Sergi Ferre, Ruben Baler, Michel Bouvier, Marc G. Caron, Lakshmi A. Devi, Thierry Durroux, Kjell Fuxe, Susan R. George, Jonathan A. Javitch, Martin J. Lohse, …

Nature chemical biology, Vol.5(3), pp.131-134

01/03/2009

DOI: https://doi.org/10.1038/nchembio0309-131

PMID: 19219011

Résumé

Biochemistry & Molecular Biology

Life Sciences & Biomedicine

Science & Technology

Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.

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Titre: Building a new conceptual framework for receptor heteromers
Créateurs - sans rôle: Sergi Ferre - NIH, Natl Inst Drug Abuse, IRP, DHHS, Baltimore, MD 21224 USA
Ruben Baler - NIH, Natl Inst Drug Abuse, DHHS, Bethesda, MD 20892 USA
Michel Bouvier - Univ Montreal, Inst Res Immunol & Canc, Montreal, PQ H3C 3J7, Canada
Marc G. Caron - Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA
Lakshmi A. Devi - Mt Sinai Sch Med, New York, NY 10029 USA
Thierry Durroux - Univ Montpellier, INSERM, CNRS, Inst Genom Fonct, F-34000 Montpellier, France
Kjell Fuxe - Karolinska Inst, S-17177 Stockholm, Sweden
Susan R. George - Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON M5S 1A8, Canada
Jonathan A. Javitch - Columbia Univ, Ctr Mol Recognit, Coll Phys & Surg, New York, NY 10032 USA
Martin J. Lohse - University of Würzburg
Ken Mackie - Indiana University Bloomington
Graeme Milligan - Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland
Kevin D. G. Pfleger - Univ Western Australia, Western Australian Inst Med Res, Nedlands, WA 6009, Australia
Jean-Philippe Pin - Univ Montpellier, INSERM, CNRS, Inst Genom Fonct, F-34000 Montpellier, France
Nora D. Volkow - NIH, Natl Inst Drug Abuse, DHHS, Bethesda, MD 20892 USA
Maria Waldhoer - Med Univ Graz, A-8010 Graz, Austria
Amina S. Woods - NIH, Natl Inst Drug Abuse, IRP, DHHS, Baltimore, MD 21224 USA
Rafael Franco - Univ Barcelona, IDIBAPS Fac Biol, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona 08028, Spain
Détails de publication: Nature chemical biology, Vol.5(3), pp.131-134
Éditeur: Springer Nature
Nombre de pages: 4
Note de subvention: ZIAAA000551 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) G9811527 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission R01 DA007223; K05 DA022413 / NIDA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) R01DA007223 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission R01 MH054137 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01MH054137 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) G9811527 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Z99 DA999999 / Intramural NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Identifiants: 99139606509311
Unité académique: Institut de Génomique Fonctionnelle - IGF
Langue: English
Type de ressource: Journal article