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Brief intraperitoneal radioimmunotherapy of small peritoneal carcinomatosis using high activities of noninternalizing 125I-labeled monoclonal antibodies.
Journal article   Open access   Peer reviewed

Brief intraperitoneal radioimmunotherapy of small peritoneal carcinomatosis using high activities of noninternalizing 125I-labeled monoclonal antibodies.

Vincent Boudousq, Stéphanie Ricaud, Véronique Garambois, Caroline Bascoul-Mollevi, Samir Boutaleb, Muriel Busson, François Quenet, Pierre-Emmanuel Colombo, Manuel Bardiès, Pierre-Olivier Kotzki, …
Journal of Nuclear Medicine, Vol.51(11), pp.1748-55
11/2010
DOI: https://doi.org/10.2967/jnumed.110.080226
PMID: 20956481

Abstract

radioimmunotherapy Auger electrons peritoneal carcinomatosis Animals Antibodies, Monoclonal Radiometry Staining and Labeling Survival Analysis Time Factors Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed Biological Transport Cell Line, Tumor Female Iodine Radioisotopes Mice Peritoneal Cavity Peritoneal Neoplasms Radioimmunotherapy
The efficiency, low toxicity, and high tumor-to-healthy tissue uptake ratio associated with brief intraperitoneal (125)I-35A7 radioimmunotherapy suggest that this method can be used in combination with radiation-synergistic drugs in the therapy of small-volume peritoneal carcinomatosis after cytoreductive surgery.
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