Biomarkers, omics and artificial intelligence for early detection of pancreatic cancer

Kate Murray; Lucy Oldfield; Irena Stefanova; Manuel Gentiluomo; Paolo Aretini; Rachel O’Sullivan; William Greenhalf; Salvatore Paiella; Mateus N. Aoki; Aldo Pastore; James Birch-Ford; Bhavana Hemantha Rao; Pinar Uysal-Onganer; Caoimhe M. Walsh; George B. Hanna; Jagriti Narang; Pradakshina Sharma; Daniele Campa; Cosmeri Rizzato; Andrei Turtoi; Elif Arik Sever; Alessio Felici; Ceren Sucularli; Giulia Peduzzi; Elif Öz; Osman Uğur Sezerman; Robert Van der Meer; Nathan Thompson; Eithne Costello

doi:10.1016/j.semcancer.2025.02.009

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Biomarkers, omics and artificial intelligence for early detection of pancreatic cancer

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Biomarkers, omics and artificial intelligence for early detection of pancreatic cancer

Kate Murray, Lucy Oldfield, Irena Stefanova, Manuel Gentiluomo, Paolo Aretini, Rachel O’Sullivan, William Greenhalf, Salvatore Paiella, Mateus N. Aoki, Aldo Pastore, …

Seminars in cancer biology, Vol.111, pp.76-88

06/2025

DOI: https://doi.org/10.1016/j.semcancer.2025.02.009

PMID: 39986585

Résumé

Artificial intelligence

Biomarkers

Early detection

Omics

Pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is frequently diagnosed in its late stages when treatment options are limited. Unlike other common cancers, there are no population-wide screening programmes for PDAC. Thus, early disease detection, although urgently needed, remains elusive. Individuals in certain high-risk groups are, however, offered screening or surveillance. Here we explore advances in understanding high-risk groups for PDAC and efforts to implement biomarker-driven detection of PDAC in these groups. We review current approaches to early detection biomarker development and the use of artificial intelligence as applied to electronic health records (EHRs) and social media. Finally, we address the cost-effectiveness of applying biomarker strategies for early detection of PDAC.

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Titre: Biomarkers, omics and artificial intelligence for early detection of pancreatic cancer
Créateurs - sans rôle: Kate Murray - Liverpool Experimental Cancer Medicine Centre, University of Liverpool, Liverpool, United Kingdom
Lucy Oldfield - Liverpool Experimental Cancer Medicine Centre, University of Liverpool, Liverpool, United Kingdom
Irena Stefanova - Liverpool Experimental Cancer Medicine Centre, University of Liverpool, Liverpool, United Kingdom
Manuel Gentiluomo - Department of Biology, University of Pisa, Italy
Paolo Aretini - Fondazione Pisana per la Scienza ONLUS, Italy
Rachel O’Sullivan - Liverpool Experimental Cancer Medicine Centre, University of Liverpool, Liverpool, United Kingdom
William Greenhalf - Liverpool Experimental Cancer Medicine Centre, University of Liverpool, Liverpool, United Kingdom
Salvatore Paiella - Pancreatic Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Italy
Mateus N. Aoki - Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Brazil
Aldo Pastore - Fondazione Pisana per la Scienza, Scuola Normale Superiore di Pisa, Italy
James Birch-Ford - Liverpool Experimental Cancer Medicine Centre, University of Liverpool, Liverpool, United Kingdom
Bhavana Hemantha Rao - Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Czech Republic
Pinar Uysal-Onganer - School of Life Sciences, Cancer Mechanisms and Biomarkers Group, The University of Westminster, United Kingdom
Caoimhe M. Walsh - Department of Surgery and Cancer, Imperial College London, United Kingdom
George B. Hanna - Imperial College London
Jagriti Narang - Department of Biotechnology, Jamia Hamdard, India
Pradakshina Sharma - Department of Biotechnology, Jamia Hamdard, India
Daniele Campa - Department of Biology, University of Pisa, Italy
Cosmeri Rizzato - Department of Biology, University of Pisa, Italy
Andrei Turtoi - Tumor Microenvironment and Resistance to Treatment Lab, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, France
Elif Arik Sever - Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Turkiye
Alessio Felici - Department of Biology, University of Pisa, Italy
Ceren Sucularli - Department of Bioinformatics, Hacettepe University, Turkiye
Giulia Peduzzi - Department of Biology, University of Pisa, Italy
Elif Öz - Department of Biostatistics and Bioinformatics, Acibadem Mehmet Ali Aydinlar University, Turkiye
Osman Uğur Sezerman - Department of Biostatistics and Bioinformatics, Acibadem Mehmet Ali Aydinlar University, Turkiye
Robert Van der Meer - University of Strathclyde, United Kingdom
Nathan Thompson - University of Strathclyde, United Kingdom
Eithne Costello - Liverpool Experimental Cancer Medicine Centre, University of Liverpool, Liverpool, United Kingdom
Détails de publication: Seminars in cancer biology, Vol.111, pp.76-88
Éditeur: Elsevier Ltd
Nombre de pages: 13
Identifiants: 99162578109311
Unité académique: Institut de Recherche en Cancérologie de Montpellier - IRCM
Langue: English
Type de ressource: Journal article