Abstract
This study investigates the mycochemical profile and biological activities of hydroethanolic (etOh), chloroform (chcl 3 ), and hot water (h 2 O) extracts of Sanghuangporus lonicerinus from Uzbekistan. antioxidant capacity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPh), 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (aBts), NO, and FRaP assays, and in vitro hypoglycaemic effects were evaluated through α-amylase and α-glucosidase inhibition. antiproliferative potential was explored by analysing the binding affinities of etOh and h 2 O extracts to estrogen receptor α (eRα), eRβ, androgen receptor (aR), and glucocorticoid receptor (GR), with molecular docking providing structural insights. lc-Ms/Ms analysis revealed solvent-dependent phenolic profiles, with the etOh extract containing the highest total phenolic content (143.15 ± 6.70 mg Gae/g d.w.) and the best antioxidant capacity. the etOh extract showed significant hypoglycaemic effects, with 85.29 ± 5.58% inhibition of α-glucosidase and 41.21 ± 0.79% inhibition of α-amylase. Moderate eRβ binding suggests potential for estrogen-mediated cancer therapy, while strong aKR1c3 inhibition by the etOh extract supports its therapeutic potential.