Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

Vincenzo Alterio; Roberta Cadoni; Davide Esposito; Daniela Vullo; Anna Di Fiore; Simona Maria Monti; Andrea Caporale; Menotti Ruvo; Mario Sechi; Pascal Dumy; Claudiu Supuran; Giuseppina de Simone; Jean-Yves Winum

doi:10.1039/c6cc06399c

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Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

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Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

Vincenzo Alterio, Roberta Cadoni, Davide Esposito, Daniela Vullo, Anna Di Fiore, Simona Maria Monti, Andrea Caporale, Menotti Ruvo, Mario Sechi, Pascal Dumy, …

Chemical Communications, Vol.52(80), pp.11983-11986

2016

DOI: https://doi.org/10.1039/c6cc06399c

Abstract

In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition properties against some carbonic anhydrases (CAs), recognized as important drug targets, and the characterization of the binding mode of these molecules to the CA active site. Our data provide the first experimental evidence that benzoxaboroles can be efficiently used as CA inhibitors.

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Title: Benzoxaborole as a new chemotype for carbonic anhydrase inhibition
Creators - without role: Vincenzo Alterio - Institute of Biostructure and Bioimaging
Roberta Cadoni - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Davide Esposito - Institute of Biostructure and Bioimaging
Daniela Vullo - Polo d’Innovazione di Genomica
Anna Di Fiore - Consiglio Nazionale delle Ricerche [Napoli]
Simona Maria Monti - Institute of Biostructure and Bioimaging
Andrea Caporale - Institute of Biostructure and Bioimaging
Menotti Ruvo - Institute of Biostructure and Bioimaging
Mario Sechi - University of Sassari
Pascal Dumy - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Claudiu Supuran - University of Florence
Giuseppina de Simone - Institute of Biostructure and Bioimaging
Jean-Yves Winum - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Publication Details: Chemical Communications, Vol.52(80), pp.11983-11986
Grant note: This work was supported by grants from CNR-DSB Progetto Bandiera “InterOmics”, the Ligue contre le Cancer (Comité des Pyrénées-Orientales) and the LabEx CheMISyst (ANR-10-LABX-05-01).
Identifiers: 9944576809311
Academic Unit: Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-03549186