BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism.

G Ghanem; M. Bensmana; M Dugoujon; J. Constans; M.P Lefranc; G. Lefranc

doi:10.1007/BF00274144

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BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism.

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BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism.

G Ghanem, M. Bensmana, M Dugoujon, J. Constans, M.P Lefranc and G. Lefranc

Human Genetics, Vol.83(1), pp.37-44

01/08/1989

DOI: https://doi.org/10.1007/BF00274144

PMID: 2570016

Abstract

In this paper, we extend the study of the IGHG gene RFLPs in black African persons and in some other individuals characterized by a Negroid admixture. We demonstrate a polymorphism that is much more important in black Africans, than in Caucasoids, mainly for the IGHG3 and G1 genes, the most 5' members of the IGHG multigene family. These genes encode for the IgG3 and IgG1 subclasses, which are of crucial biological importance.

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Title: BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism.
Creators - without role: G Ghanem - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
M. Bensmana - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
M Dugoujon - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
J. Constans - Centre Hospitalier Universitaire de Bordeaux
M.P Lefranc - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
G. Lefranc - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Publication Details: Human Genetics, Vol.83(1), pp.37-44
Identifiers: 9946342809311
Academic Unit: Institut de Génétique Moléculaire de Montpellier - IGMM
Language: English
Resource Type: Journal article
Local Fields: hal-01946220