B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates

Chengyang Liu; Hooman Noorchashm; Jennifer A Sutter; Mina Naji; Eline Luning Prak; Jean Boyer; Taryn Green; Michael R Rickels; John E Tomaszewski; Brigitte Koeberlein; Zhonglin Wang; Michelle E Paessler; Ergun Velidedeoglu; Susan Y Rostami; Ming Yu; Clyde F Barker; Ali Naji

doi:10.1038/nm1673

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B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates

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B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates

Chengyang Liu, Hooman Noorchashm, Jennifer A Sutter, Mina Naji, Eline Luning Prak, Jean Boyer, Taryn Green, Michael R Rickels, John E Tomaszewski, Brigitte Koeberlein, …

Nature medicine, Vol.13(11), pp.1295-1298

01/11/2007

DOI: https://doi.org/10.1038/nm1673

PMID: 17965721

Résumé

Article

Biomedical and Life Sciences

Biomedicine

brief-communication

Cancer Research

Général

Infectious Diseases

Metabolic Diseases

Molecular Medicine

Neurosciences

We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitution after rituximab-mediated depletion was characterized by a preponderance of immature and transitional cells, whose persistence was associated with long-term islet allograft survival. Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy.

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Titre: B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates
Créateurs - sans rôle: Chengyang Liu - Department of Surgery, University of Pennsylvania School of Medicine
Hooman Noorchashm - Department of Surgery, University of Pennsylvania School of Medicine
Jennifer A Sutter - Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine
Mina Naji - Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine
Eline Luning Prak - Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine
Jean Boyer - Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine
Taryn Green - Department of Surgery, University of Pennsylvania School of Medicine
Michael R Rickels - Department of Medicine, University of Pennsylvania School of Medicine
John E Tomaszewski - Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine
Brigitte Koeberlein - Department of Surgery, University of Pennsylvania School of Medicine
Zhonglin Wang - Department of Surgery, University of Pennsylvania School of Medicine
Michelle E Paessler - Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia
Ergun Velidedeoglu - Department of Surgery, University of Pennsylvania School of Medicine
Susan Y Rostami - Department of Surgery, University of Pennsylvania School of Medicine
Ming Yu - Department of Surgery, University of Pennsylvania School of Medicine
Clyde F Barker - Department of Surgery, University of Pennsylvania School of Medicine
Ali Naji - Department of Surgery, University of Pennsylvania School of Medicine
Détails de publication: Nature medicine, Vol.13(11), pp.1295-1298
Éditeur: Nature Publishing Group US
Nombre de pages: 4
Identifiants: 99155075109311
Unité académique: Institut des Sciences des Plantes de Montpellier - IPSiM
Langue: English
Type de ressource: Journal article