Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Paul Bastard; Adrian Gervais; Tom Le Voyer; Jérémie Rosain; Quentin Philippot; Jérémy Manry; Eleftherios Michailidis; Hans-Heinrich Hoffmann; Shohei Eto; Marina Garcia-Prat; Lucy Bizien; Alba Parra-Martínez; Rui Yang; Liis Haljasmägi; Mélanie Migaud; Karita Särekannu; Julia Maslovskaja; Nicolas de Prost; Yacine Tandjaoui-Lambiotte; Charles-Edouard Luyt; Blanca Amador-Borrero; Alexandre Gaudet; Julien Poissy; Pascal Morel; Pascale Richard; Fabrice Cognasse; Jesus Troya; Sophie Trouillet-Assant; Alexandre Belot; Kahina Saker; Pierre Garçon; Jacques G Rivière; Jean-Christophe Lagier; Stéphanie Gentile; Lindsey B Rosen; Elana Shaw; Tomohiro Morio; Junko Tanaka; David Dalmau; Pierre-Louis Tharaux; Damien Sene; Alain Stepanian; Bruno Megarbane; Vasiliki Triantafyllia; Arnaud Fekkar; James R Heath; José Luis Franco; Juan-Manuel Anaya; Jordi Solé-Violán; Luisa Imberti; Andrea Biondi; Paolo Bonfanti; Riccardo Castagnoli; Ottavia M Delmonte; Yu Zhang; Andrew L Snow; Steven M Holland; Catherine M Biggs; Marcela Moncada-Vélez; Andrés Augusto Arias; Lazaro Lorenzo; Soraya Boucherit; Boubacar Coulibaly; Dany Anglicheau; Anna M Planas; Filomeen Haerynck; Sotirija Duvlis; Robert L Nussbaum; Tayfun Ozcelik; Sevgi Keles; Ahmed A Bousfiha; Jalila El Bakkouri; Carolina Ramirez-Santana; Stéphane Paul; Qiang Pan-Hammarström; Lennart Hammarström; Annabelle Dupont; Alina Kurolap; Christine N Metz; Alessandro Aiuti; Giorgio Casari; Vito Lampasona; Fabio Ciceri; Lucila A Barreiros; Elena Dominguez-Garrido; Mateus Vidigal; Mayana Zatz; Diederik van de Beek; Sabina Sahanic; Ivan Tancevski; Yurii Stepanovskyy; Oksana Boyarchuk; Yoko Nukui; Miyuki Tsumura; Loreto Vidaur; Stuart G Tangye; Sonia Burrel; Darragh Duffy; Lluis Quintana-Murci; Adam Klocperk; Nelli Y Kann; Anna Shcherbina; Yu-Lung Lau; Daniel Leung; Matthieu Coulongeat; Julien Marlet; Rutger Koning; Luis Felipe Reyes; Angélique Chauvineau-Grenier; Fabienne Venet; Guillaume Monneret; Michel C Nussenzweig; Romain Arrestier; Idris Boudhabhay; Hagit Baris-Feldman; David Hagin; Joost Wauters; Isabelle Meyts; Adam H Dyer; Sean P Kennelly; Nollaig M Bourke; Rabih Halwani; Narjes Saheb Sharif-Askari; Karim Dorgham; Jérome Sallette; Souad Mehlal Sedkaoui; Suzan AlKhater; Raúl Rigo-Bonnin; Francisco Morandeira; Lucie Roussel; Donald C Vinh; Sisse Rye Ostrowski; Antonio Condino-Neto; Carolina Prando; Anastasiia Bondarenko; András N Spaan; Laurent Gilardin; Jacques Fellay; Stanislas Lyonnet; Kaya Bilguvar; Richard P Lifton; Shrikant Mane; Mark S Anderson; Bertrand Boisson; Vivien Béziat; Shen-Ying Zhang; Evangelos Andreakos; Olivier Hermine; Aurora Pujol; Pärt Peterson; Trine H Mogensen; Lee Rowen; James Mond; Stéphanie Debette; Xavier de Lamballerie; Xavier Duval; France Mentré; Marie Zins; Pere Soler-Palacin; Roger Colobran; Guy Gorochov; Xavier Solanich; Sophie Susen; Javier Martinez-Picado; Didier Raoult; Marc Vasse; Peter K Gregersen; Lorenzo Piemonti; Carlos Rodríguez-Gallego; Luigi D Notarangelo; Helen C Su; Kai Kisand; Satoshi Okada; Anne Puel; Emmanuelle Jouanguy; Charles M Rice; Pierre Tiberghien; Qian Zhang; Aurélie Cobat; Laurent Abel; Jean-Laurent Casanova; [missing] HGID Lab; [missing] COVID Clinicians; [missing] COVID-STORM Clinicians; [missing] NIAID Immune Response to COVID Group; [missing] NH-COVAIR Study Group; [missing] Danish CHGE; [missing] Danish Blood Donor Study; [missing] St. James’s Hospital SARS CoV2 Interest group; [missing] French COVID Cohort Study Group; [missing] Imagine COVID-Group; [missing] The Milieu Intérieur Consortium; [missing] CoV-Contact Cohort; [missing] Amsterdam UMC Covid- Biobank Investigators; [missing] COVID Human Genetic Effort; [missing] CONSTANCES cohort; [missing] 3C-Dijon Study; [missing] Cerba HealthCare; [missing] Etablissement du Sang study group; Jens Van Praet; Bart Lambrecht; Eva Van Braeckel; Cedric Bosteels; Levi Hoste; Eric Hoste; Fre Bauters; Leslie Naesens

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Article de revue

Avec comité de lecture

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Paul Bastard, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Jérémy Manry, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina Garcia-Prat, …

2021

Résumé

ALPHA

ANTIBODIES

ANTINUCLEAR

AUTOIMMUNITY

DISTINCT FUNCTIONS

General Medicine

IMMUNITY

Immunology

INTERFERON

Medicine and Health Sciences

MYASTHENIA-GRAVIS PATIENTS

PATIENT

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-alpha and/or IFN-omega are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-alpha and/or IFN-omega (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-beta. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-alpha and/or IFN-omega are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-beta do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases.

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Détails

Titre: Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Créateurs - sans rôle: Paul Bastard
Adrian Gervais
Tom Le Voyer
Jérémie Rosain
Quentin Philippot
Jérémy Manry
Eleftherios Michailidis
Hans-Heinrich Hoffmann
Shohei Eto
Marina Garcia-Prat
Lucy Bizien
Alba Parra-Martínez
Rui Yang
Liis Haljasmägi
Mélanie Migaud
Karita Särekannu
Julia Maslovskaja
Nicolas de Prost
Yacine Tandjaoui-Lambiotte
Charles-Edouard Luyt
Blanca Amador-Borrero
Alexandre Gaudet
Julien Poissy
Pascal Morel
Pascale Richard
Fabrice Cognasse
Jesus Troya
Sophie Trouillet-Assant
Alexandre Belot
Kahina Saker
Pierre Garçon
Jacques G Rivière
Jean-Christophe Lagier
Stéphanie Gentile
Lindsey B Rosen
Elana Shaw
Tomohiro Morio
Junko Tanaka
David Dalmau
Pierre-Louis Tharaux
Damien Sene
Alain Stepanian
Bruno Megarbane
Vasiliki Triantafyllia
Arnaud Fekkar
James R Heath
José Luis Franco
Juan-Manuel Anaya
Jordi Solé-Violán
Luisa Imberti
Andrea Biondi
Paolo Bonfanti
Riccardo Castagnoli
Ottavia M Delmonte
Yu Zhang
Andrew L Snow
Steven M Holland
Catherine M Biggs
Marcela Moncada-Vélez
Andrés Augusto Arias
Lazaro Lorenzo
Soraya Boucherit
Boubacar Coulibaly
Dany Anglicheau
Anna M Planas
Filomeen Haerynck
Sotirija Duvlis
Robert L Nussbaum
Tayfun Ozcelik
Sevgi Keles
Ahmed A Bousfiha
Jalila El Bakkouri
Carolina Ramirez-Santana
Stéphane Paul
Qiang Pan-Hammarström
Lennart Hammarström
Annabelle Dupont
Alina Kurolap
Christine N Metz
Alessandro Aiuti
Giorgio Casari
Vito Lampasona
Fabio Ciceri
Lucila A Barreiros
Elena Dominguez-Garrido
Mateus Vidigal
Mayana Zatz
Diederik van de Beek
Sabina Sahanic
Ivan Tancevski
Yurii Stepanovskyy
Oksana Boyarchuk
Yoko Nukui
Miyuki Tsumura
Loreto Vidaur
Stuart G Tangye
Sonia Burrel
Darragh Duffy
Lluis Quintana-Murci
Adam Klocperk
Nelli Y Kann
Anna Shcherbina
Yu-Lung Lau
Daniel Leung
Matthieu Coulongeat
Julien Marlet
Rutger Koning
Luis Felipe Reyes
Angélique Chauvineau-Grenier
Fabienne Venet
Guillaume Monneret
Michel C Nussenzweig
Romain Arrestier
Idris Boudhabhay
Hagit Baris-Feldman
David Hagin
Joost Wauters
Isabelle Meyts
Adam H Dyer
Sean P Kennelly
Nollaig M Bourke
Rabih Halwani
Narjes Saheb Sharif-Askari
Karim Dorgham
Jérome Sallette
Souad Mehlal Sedkaoui
Suzan AlKhater
Raúl Rigo-Bonnin
Francisco Morandeira
Lucie Roussel
Donald C Vinh
Sisse Rye Ostrowski
Antonio Condino-Neto
Carolina Prando
Anastasiia Bondarenko
András N Spaan
Laurent Gilardin
Jacques Fellay
Stanislas Lyonnet
Kaya Bilguvar
Richard P Lifton
Shrikant Mane
Mark S Anderson
Bertrand Boisson
Vivien Béziat
Shen-Ying Zhang
Evangelos Andreakos
Olivier Hermine
Aurora Pujol
Pärt Peterson
Trine H Mogensen
Lee Rowen
James Mond
Stéphanie Debette
Xavier de Lamballerie
Xavier Duval
France Mentré
Marie Zins
Pere Soler-Palacin
Roger Colobran
Guy Gorochov
Xavier Solanich
Sophie Susen
Javier Martinez-Picado
Didier Raoult
Marc Vasse
Peter K Gregersen
Lorenzo Piemonti
Carlos Rodríguez-Gallego
Luigi D Notarangelo
Helen C Su
Kai Kisand
Satoshi Okada
Anne Puel
Emmanuelle Jouanguy
Charles M Rice
Pierre Tiberghien
Qian Zhang
Aurélie Cobat
Laurent Abel
Jean-Laurent Casanova
[missing] HGID Lab
[missing] COVID Clinicians
[missing] COVID-STORM Clinicians
[missing] NIAID Immune Response to COVID Group
[missing] NH-COVAIR Study Group
[missing] Danish CHGE
[missing] Danish Blood Donor Study
[missing] St. James’s Hospital SARS CoV2 Interest group
[missing] French COVID Cohort Study Group
[missing] Imagine COVID-Group
[missing] The Milieu Intérieur Consortium
[missing] CoV-Contact Cohort
[missing] Amsterdam UMC Covid- Biobank Investigators
[missing] COVID Human Genetic Effort
[missing] CONSTANCES cohort
[missing] 3C-Dijon Study
[missing] Cerba HealthCare
[missing] Etablissement du Sang study group
Jens Van Praet
Bart Lambrecht
Eva Van Braeckel
Cedric Bosteels
Levi Hoste
Eric Hoste
Fre Bauters
Leslie Naesens
Identifiants: 99148826809311
Unité académique: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Langue: English
Type de ressource: Journal article