Résumé
Aurora mitotic protein kinases (A, B and C) are frequently overexpressed in cells from various tumor types. Additionally, overexpression of Aurora-A is sufficient to transform NIH/3T3 cells to induce tumor formation when implanted in nude mice. Altogether, these results have led many pharmaceutical companies to design Aurora kinase inhibitors with the hope of discovering new anticancer molecules. Several novel compounds that target the ATP pocket have recently been discovered. In this review we suggest other alternative strategies that might be useful for specifically inhibiting individual Aurora kinases.