Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans

Matthias M Mauschitz; Timo Verzijden; Alexander K Schuster; Hisham Elbaz; Norbert Pfeiffer; Anthony Khawaja; Robert N Luben; Paul J Foster; Franziska G Rauscher; Kerstin Wirkner; Toralf Kirsten; Jost B Jonas; Mukharram M Bikbov; Ruth Hogg; Tunde Peto; Audrey Cougnard-Grégoire; Geir Bertelsen; Maja Gran Erke; Fotis Topouzis; Dimitrios A Giannoulis; Caroline Brandl; Iris M Heid; Catherine P Creuzot-Garcher; Pierre-Henry Gabrielle; Hans-Werner Hense; Daniel Pauleikhoff; Patricia Barreto; Rita Coimbra; Stefano Piermarocchi; Vincent Daien; Frank G Holz; Cecile Delcourt; Robert P Finger; European Eye Epidemiology E3 Conso

doi:10.1136/bjo-2022-321985

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Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans

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Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans

Matthias M Mauschitz, Timo Verzijden, Alexander K Schuster, Hisham Elbaz, Norbert Pfeiffer, Anthony Khawaja, Robert N Luben, Paul J Foster, Franziska G Rauscher, Kerstin Wirkner, …

British journal of ophthalmology, Vol.107(12), pp.1880-1886

01/12/2023

DOI: https://doi.org/10.1136/bjo-2022-321985

PMID: 36344262

Résumé

Clinical science

drugs

epidemiology

Background/aimsTo investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population.MethodsWe included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis.ResultsBetween studies, mean age ranged from 61.5±7.1 to 82.6±3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication.ConclusionOur study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD.

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Titre: Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans
Créateurs - sans rôle: Matthias M Mauschitz - University Hospital Bonn
Timo Verzijden - Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
Alexander K Schuster - Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
Hisham Elbaz - Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
Norbert Pfeiffer - Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
Anthony Khawaja - University of Cambridge
Robert N Luben - University of Cambridge
Paul J Foster - Moorfields Eye Hospital NHS Foundation Trust
Franziska G Rauscher - Leipzig University
Kerstin Wirkner - Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, 04103 Leipzig, Germany
Toralf Kirsten - Leipzig University Medical Center, Medical Informatics Center - Dept. of Medical Data Science, 04107 Leipzig, Germany
Jost B Jonas - Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland
Mukharram M Bikbov - Ufa Eye Research Institute
Ruth Hogg - Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK
Tunde Peto - Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK
Audrey Cougnard-Grégoire - Bordeaux Population Health
Geir Bertelsen - University Hospital of North Norway
Maja Gran Erke - Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
Fotis Topouzis - Aristotle University of Thessaloniki
Dimitrios A Giannoulis - Department of Ophthalmology, Aristotle University of Thessaloniki, School of Medicine, AHEPA Hospital, Thessaloniki, Greece
Caroline Brandl - Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany
Iris M Heid - Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany
Catherine P Creuzot-Garcher - Department of Ophthalmology, University Hospital Dijon, Dijon, France
Pierre-Henry Gabrielle - Department of Ophthalmology, University Hospital Dijon, Dijon, France
Hans-Werner Hense - University of Münster, Faculty of Medicine, Institute of Epidemiology, Münster, Germany
Daniel Pauleikhoff - Department of Ophthalmology, St. Franzikus-Hospital, Münster, Germany
Patricia Barreto - Univ Coimbra, Centre for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal
Rita Coimbra - AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
Stefano Piermarocchi - University of Padova, Department of Neuroscience, Padova, Italy
Vincent Daien - The Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
Frank G Holz - University Hospital Bonn
Cecile Delcourt - Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Team LEHA, F-33000 Bordeaux, France
Robert P Finger - University Hospital Bonn
European Eye Epidemiology E3 Conso
Détails de publication: British journal of ophthalmology, Vol.107(12), pp.1880-1886
Éditeur: BMJ Publishing Group Ltd
Nombre de pages: 7
Note de subvention: AZ 961-386261/733 / Stiftung Rheinland-Pfalz für Innovation (http://dx.doi.org/10.13039/501100004346)
Identifiants: 99139926809311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article