Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study

F. Balazard; S. Le Fur; S. Valtat; A. Valleron; Dominique Thevenieau; Corinne Fourmy Chatel; Rachel Desailloud; Hélène Bony-Trifunovic; Pierre-Henri Ducluzeau; Régis Coutant; Sophie Caudrelier; Armelle Pambou; Emmanuelle Dubosclard; Florence Joubert; Philippe Jan; Estelle Marcoux; Anne-Marie Bertrand; Brigitte Mignot; Alfred Penformis; Chantal Stuckens; Régis Piquemal; Pascal Barat; Vincent Rigalleau; Chantal Stheneur; Sylviane Fournier; Véronique Kerlan; Chantal Metz; Anne Fargeot-Espaliat; Yves Reznic; Frédérique Olivier; Iva Gueorguieva; Arnaud Monier; Catherine Radet; Vincent Gajdos; Daniel Terral; Christine Vervel; Djamel Bendifallah; Candace Ben Signor; Daniel Dervaux; Abdelkader Benmahammed; Guy-André Loeuille; Françoise Popelard; Agnès Guillou; Yves Benhamou; Jamil Khoury; Jean-Pierre Brossier; Joachim Bassil; Sylvaine Clavel; Bernard Le Luyer; Pierre Bougnères; Françoise Labay; Isabelle Guemas; Jacques Weill; Jean-Pierre Cappoen; Sylvie Nadalon; Anne Lienhardt-Roussie; Anne Paoli; Claudie Kerouedan; Edwige Yollin; Marc Nicolino; Gilbert Simonin; Jacques Cohen; Catherine Atlan; Agnès Tamboura; Hervé Dubourg; Marie-Laure Pignol; Philippe Talon; Stéphanie Jellimann; Lucy Chaillous; Sabine Baron; Marie-Noëlle Bortoluzzi; Elisabeth Baechler; Randa Salet; Ariane Zelinsky-Gurung; Fabienne Dallavale; Etienne Larger; Marie Laloi-Michelin; Jean-François Gautier; Bénédicte Guérin; Laure Oilleau; Laetitia Pantalone; Céline Lukas; Isabelle Guilhem; Marc de Kerdanet; Marie Wielickzo; Mélanie Priou-Guesdon; Odile Richard; François Kurtz; Norbert Laisney; Déborah Ancelle; Guilhem Guilhem; Catherine Boniface; Dominique Bockel; Denis Dufillot; Berthe Razafimahefa; Pierre Gourdy; Pierre B.A. Lecomte; Myriam Pepin-Donat; Emmanuelle Combes-Moukhovsky; Brigitte Zymmermann; Marina Raoulx; Anne Dumont

doi:10.1186/s12889-016-3690-9

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Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study

Journal article

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Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study

F. Balazard, S. Le Fur, S. Valtat, A. Valleron, Dominique Thevenieau, Corinne Fourmy Chatel, Rachel Desailloud, Hélène Bony-Trifunovic, Pierre-Henri Ducluzeau, Régis Coutant, …

BMC Public Health, Vol.16(1)

12/2016

DOI: https://doi.org/10.1186/s12889-016-3690-9

PMCID: PMC5041527

PMID: 27682602

Abstract

Case–control

Epidemiology

Type 1 diabetes

Data-driven

Environment

Background : The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedlybecause of changing environmental factors, which are yet largely unknown. The purpose of the study was tounravel environmental markers associated with T1D. Methods : Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends ofthe patients. Parents were asked to fill a 845-item questionnaire investigating the child’s environment before diagnosis.The analysis took into account the matching between cases and controls. A second analysis used propensity scoremethods. Results : We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnutcocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a petby old age. Conclusions : The found statistical association of new environmental markers with T1D calls for replication in othercohorts and investigation of new environmental areas.

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Title: Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study
Creators - without role: F. Balazard - Centre National de la Recherche Scientifique
S. Le Fur - Inserm
S. Valtat - Inserm
A. Valleron - Bicêtre Hospital
Dominique Thevenieau
Corinne Fourmy Chatel
Rachel Desailloud - Centre Hospitalier Universitaire Amiens-Picardie
Hélène Bony-Trifunovic
Pierre-Henri Ducluzeau - Service Endocrinologie-Diabétologie
Régis Coutant - Centre Hospitalier Universitaire d'Angers
Sophie Caudrelier
Armelle Pambou - Centre Hospitalier d'Arras
Emmanuelle Dubosclard
Florence Joubert - Université Grenoble Alpes
Philippe Jan
Estelle Marcoux
Anne-Marie Bertrand - Centre Gabriel Naudé
Brigitte Mignot - Centre Hospitalier Universitaire de Besançon
Alfred Penformis
Chantal Stuckens - Pédiatrie-diabétologie
Régis Piquemal
Pascal Barat - NutriNeuro
Vincent Rigalleau - Hôpital Cardiologique du Haut-Lévêque
Chantal Stheneur - Consultation Marfan
Sylviane Fournier
Véronique Kerlan - Hôpital Maison Blanche
Chantal Metz
Anne Fargeot-Espaliat - Pédiatrie Neonatalogie, Centre Hospitalier Général, Brive-la-Gaillarde, Brive-la-Gaillarde, France
Yves Reznic
Frédérique Olivier - Institute for Marine and Antarctic Studies
Iva Gueorguieva - Eli Lilly
Arnaud Monier
Catherine Radet
Vincent Gajdos - Centre de recherche en Epidémiologie et Santé des Populations
Daniel Terral - Hôtel-Dieu de Paris
Christine Vervel
Djamel Bendifallah
Candace Ben Signor - Charmo University
Daniel Dervaux
Abdelkader Benmahammed
Guy-André Loeuille
Françoise Popelard - Service de Pédiatrie
Agnès Guillou
Yves Benhamou - Charmo University
Jamil Khoury
Jean-Pierre Brossier
Joachim Bassil - Roche
Sylvaine Clavel
Bernard Le Luyer - Université Le Havre Normandie
Pierre Bougnères - Thérapie génique, Génomique et Epigénomique
Françoise Labay
Isabelle Guemas
Jacques Weill - Lille’s Cardiology Hospital
Jean-Pierre Cappoen
Sylvie Nadalon - Hôpital Universitaire Dupuytren
Anne Lienhardt-Roussie - Hôpital Mère-Enfant
Anne Paoli - Laboratoire Identité Culturelle, Textes et Théâtralité
Claudie Kerouedan
Edwige Yollin
Marc Nicolino - Hospices Civils de Lyon
Gilbert Simonin
Jacques Cohen - Institut d'Informatique et de Mathématiques Appliquées de Grenoble
Catherine Atlan - Institut des Mondes Africains
Agnès Tamboura
Hervé Dubourg
Marie-Laure Pignol
Philippe Talon
Stéphanie Jellimann
Lucy Chaillous - Institut du Thorax
Sabine Baron - Centre Hospitalier Universitaire de Nantes
Marie-Noëlle Bortoluzzi
Elisabeth Baechler
Randa Salet
Ariane Zelinsky-Gurung
Fabienne Dallavale
Etienne Larger - Unité de recherche sur les maladies cardiovasculaires et métaboliques
Marie Laloi-Michelin
Jean-François Gautier - Charmo University
Bénédicte Guérin
Laure Oilleau
Laetitia Pantalone
Céline Lukas
Isabelle Guilhem - Centre Hospitalier Universitaire de Rennes
Marc de Kerdanet - Service de Pédiatrie
Marie Wielickzo
Mélanie Priou-Guesdon
Odile Richard
François Kurtz
Norbert Laisney
Déborah Ancelle
Guilhem Guilhem
Catherine Boniface
Dominique Bockel
Denis Dufillot
Berthe Razafimahefa
Pierre Gourdy - Hôpital Rangueil
Pierre B.A. Lecomte - Geothalg
Myriam Pepin-Donat
Emmanuelle Combes-Moukhovsky
Brigitte Zymmermann
Marina Raoulx
Anne Dumont
Publication Details: BMC Public Health, Vol.16(1)
Identifiers: 9938931509311
Academic Unit: Université de Montpellier
Language: English
Resource Type: Journal article
Local Fields: hal-02038642