Assessment of neuronal and glial serum biomarkers in myelin oligodendrocyte glycoprotein antibody-associated disease: the MULTIMOGAD study

Romain Marignier; Javier Villacieros-alvarez; Carmen Espejo; Georgin Arrambide; Nicolas Fissolo; Lucia Gutierrez; Alessandro Dinoto; Patricia Mulero; Laura Rubio-Flores; Pablo Nieto; Carmen Alcala; Jose E. Meca-Lallana; Pedro Martinez-Garcia; Jorge Millan; Raphael Bernard-Valnet; Ines Gonzalez; Aida Orviz Garcia; Raquel Tellez; Laura Navarro; Silvia Presas-Rodriguez; Lucia Romero-Pinel; Sergio Martinez-Yelamos; Juan Pablo Cuello; Ana Maria Alonso Torres; Raquel Pinar; Gary Alvarez Bravo; Lakhdar Benyahya; Sophie Trouillet-Assant; Virginie Dyon-Tafani; Caroline Froment Tilikete; Aurelie Ruet; Bertrand Bourre; Romain Deschamps; Caroline Papeix; Elisabeth Maillart; Philippe Kerschen; Xavier Ayrignac; Alex Rovira; Cristina Auger; Bertrand Audoin; Xavier Montalban; Mar Tintore; Sara Mariotto; Alvaro Cobo-Calvo

doi:10.1136/jnnp-2024-335137

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Assessment of neuronal and glial serum biomarkers in myelin oligodendrocyte glycoprotein antibody-associated disease: the MULTIMOGAD study

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Assessment of neuronal and glial serum biomarkers in myelin oligodendrocyte glycoprotein antibody-associated disease: the MULTIMOGAD study

Romain Marignier, Javier Villacieros-alvarez, Carmen Espejo, Georgin Arrambide, Nicolas Fissolo, Lucia Gutierrez, Alessandro Dinoto, Patricia Mulero, Laura Rubio-Flores, Pablo Nieto, …

Journal of neurology, neurosurgery and psychiatry, Vol.96(9), pp.884-892

01/09/2025

DOI: https://doi.org/10.1136/jnnp-2024-335137

PMID: 39939136

Résumé

Clinical Neurology

Life Sciences & Biomedicine

Neurosciences & Neurology

Psychiatry

Science & Technology

Surgery

Background Serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) have emerged as important biomarkers in multiple sclerosis (MS) and aquaporin-4 seropositive neuromyelitis optica spectrum disorder (AQP4-NMOSD). However, their interest in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remains unclear. Our aim was to characterise sNfL and sGFAP profile and analyse their usefulness in predicting relapses and disability in MOGAD. Methods Retrospective study of adult MOGAD patients with serum samples collected at baseline (<= 3 months from disease onset) and follow-up (>6 months from baseline sample). sNfL and sGFAP were analysed using Simoa HD-1, and values were compared across time-points. The association between biomarkers and clinical variables and their predictive value for disability and relapses were analysed. Results Eighty-nine MOGAD patients were included. Baseline sNfL and sGFAP values were high at baseline and decreased over time (p<0.001, p=0.027, respectively). sNfL and sGFAP values were associated with Expanded Disability Status Scale (EDSS) at attacks (beta 0.15 (0.06; 0.25), p=0.002; beta 0.14 (0.07; 0.21), p<0.001, respectively) and were lower in optic neuritis presentations (beta -0.69 (-1.18; -0.19), p=0.007; beta -0.42 (-0.76; -0.08), p=0.016). Biomarker deltas[Delta] (baseline values - second samples values) were associated with Delta EDSS (initial EDSS - final EDSS) (Delta sNfL beta 0.52 (0.01; 1.04), p=0.046; Delta sGFAP beta 1.07 (0.38; 1.75), p=0.003). Finally, sNfL values independently predicted the risk of relapses (HR 2.06 (1.41; 3.01), p<0.001). Conclusions Our results on sNfL and sGFAP suggest initial neuro-axonal and astrocytic damage in MOGAD and the utility of these biomarkers at onset and follow-up in predicting clinical recovery and relapses.

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Détails

Titre: Assessment of neuronal and glial serum biomarkers in myelin oligodendrocyte glycoprotein antibody-associated disease: the MULTIMOGAD study
Créateurs - sans rôle: Romain Marignier - Hosp Civils Lyon, Hop Neurol Pierre Wertheimer, Serv Neurol, Sclerose Plaques Pathol Myeline & Neuroinflammat, Lyon, France
Javier Villacieros-alvarez - Hosp Univ Vall Hebron, Vall Hebron Inst Recerca, Ctr Esclerosi Multiple Catalunya Cemcat, Neurol Dept, Barcelona, Spain
Carmen Espejo - Hosp Univ Vall Hebron, Vall Hebron Inst Recerca, Ctr Esclerosi Multiple Catalunya Cemcat, Neurol Dept, Barcelona, Spain
Georgin Arrambide - Hosp Univ Vall Hebron, Vall Hebron Inst Recerca, Ctr Esclerosi Multiple Catalunya Cemcat, Neurol Dept, Barcelona, Spain
Nicolas Fissolo - Hosp Univ Vall Hebron, Vall Hebron Inst Recerca, Ctr Esclerosi Multiple Catalunya Cemcat, Neurol Dept, Barcelona, Spain
Lucia Gutierrez - Hosp Univ Vall Hebron, Vall Hebron Inst Recerca, Ctr Esclerosi Multiple Catalunya Cemcat, Neurol Dept, Barcelona, Spain
Alessandro Dinoto - Hosp Clin Univ Valladolid, Serv Neurol, Valladolid, Spain
Patricia Mulero - Aravaca & Arturo Soria Univ Hosp, Vithas La Milagrosa, Synaptia Madrid Neurosci, Madrid, Spain
Laura Rubio-Flores - Hosp Univ Rey Juan Carlos, Serv Neurocirugia, Madrid, Spain
Pablo Nieto - Hosp Univ & Politecn La Fe, Unidad Neuroinmunol, Valencia, Spain
Carmen Alcala - Virgen La Arrixaca Clin Univ Hosp, Neurol Dept, Multiple Sclerosis CSUR, Clin Neuroimmunol Unit,IMIB Arrixaca, Murcia, Spain
Jose E. Meca-Lallana - Univ Lausanne, Lausanne Univ Hosp, Ctr Hosp Univ Vaudois, Lausanne, Switzerland
Pedro Martinez-Garcia - Univ Lausanne, Lausanne Univ Hosp, Ctr Hosp Univ Vaudois, Lausanne, Switzerland
Jorge Millan - Univ Lausanne, Lausanne Univ Hosp, Ctr Hosp Univ Vaudois, Lausanne, Switzerland
Raphael Bernard-Valnet - Hosp Gen Univ Elche, Dept Neurol, Alicante, Spain
Ines Gonzalez - Germans Trias & Pujol Hosp, Radiol Dept, Barcelona, Spain
Aida Orviz Garcia - Hosp Univ Bellvitge, Dept Clin Sci,Hosp Univ Bellvitge, Inst Invest Biomed Bellvitge IDIBELL,Neurol & Neur, Sch Med,Multiple Sclerosis Unit,Dept Neurol,Neuros, LHospitalet De Llobregat, Barcelona, Spain
Raquel Tellez - Hosp Univ Bellvitge, Dept Clin Sci,Hosp Univ Bellvitge, Inst Invest Biomed Bellvitge IDIBELL,Neurol & Neur, Sch Med,Multiple Sclerosis Unit,Dept Neurol,Neuros, LHospitalet De Llobregat, Barcelona, Spain
Laura Navarro - Hosp Reg Univ Malaga, Malaga, Spain
Silvia Presas-Rodriguez - Hosp Univ Clin San Cecilio, Serv Neurol, Granada, Spain
Lucia Romero-Pinel - Hosp Univ Girona Dr Josep Trueta, Hosp Santa Caterina, Unitat Neuroimmunol & Esclerosi Multiple Terr Giro, Girona 17190, Spain
Sergio Martinez-Yelamos - Hosp Univ Girona Dr Josep Trueta, Hosp Santa Caterina, Unitat Neuroimmunol & Esclerosi Multiple Terr Giro, Girona 17190, Spain
Juan Pablo Cuello - Hosp Civils Lyon, Hop Neurol Pierre Wertheimer, Neuropsychol Lab, Bron, France
Ana Maria Alonso Torres - Ctr Hosp Univ Bordeaux, Bordeaux, France
Raquel Pinar - CHU Hop Rouen, Rouen, France
Gary Alvarez Bravo - Fdn Adolphe Rothschild Hosp, Paris, France
Lakhdar Benyahya - Hosp Civils Lyon, Hop Neurol Pierre Wertheimer, Serv Neurol, Sclerose Plaques Pathol Myeline & Neuroinflammat, Lyon, France
Sophie Trouillet-Assant - Montpellier Univ Hosp, Montpellier, France
Virginie Dyon-Tafani - Montpellier Univ Hosp, Montpellier, France
Caroline Froment Tilikete - Univ Autonoma Barcelona, Vall Hebron Hosp Univ, Vall Hebron Inst Recerca, Dept Radiol IDI,Sect Neuroradiol, Barcelona, Spain
Aurelie Ruet - Inserm
Bertrand Bourre - CHU Rouen, Neurol, Rouen, France
Romain Deschamps - Fdn Adolphe Rothschild Hosp, Paris, France
Caroline Papeix - Fdn Ophtalmol Adolphe Rothschild, Paris, Ile De France, France
Elisabeth Maillart - Fdn Ophtalmol Adolphe Rothschild, Paris, Ile De France, France
Philippe Kerschen - Ctr Hosp Luxembourg, Luxembourg Ville, Luxembourg, Luxembourg
Xavier Ayrignac - Montpellier Univ Hosp, Montpellier, France
Alex Rovira - Univ Autonoma Barcelona, Vall Hebron Hosp Univ, Hosp Univ Vall Hebron,Sect Neuroradiol, Vall Hebron Inst Recerca,Dept Radiol IDI, Pg Vall dHebron 119-129, Barcelona 08035, Spain
Cristina Auger - Univ Autonoma Barcelona, Vall Hebron Hosp Univ, Hosp Univ Vall Hebron,Sect Neuroradiol, Vall Hebron Inst Recerca,Dept Radiol IDI, Pg Vall dHebron 119-129, Barcelona 08035, Spain
Bertrand Audoin - Assistance Publ Hop Marseille, Marseille, France
Xavier Montalban - Hosp Univ Vall Hebron, Vall Hebron Inst Recerca, Ctr Esclerosi Multiple Catalunya Cemcat, Neurol Dept, Barcelona, Spain
Mar Tintore - Centre d'Esclerosi Múltiple de Catalunya
Sara Mariotto - Hosp Clin Univ Valladolid, Serv Neurol, Valladolid, Spain
Alvaro Cobo-Calvo - Hosp Univ Vall Hebron, Vall Hebron Inst Recerca, Ctr Esclerosi Multiple Catalunya Cemcat, Neurol Dept, Barcelona, Spain
Détails de publication: Journal of neurology, neurosurgery and psychiatry, Vol.96(9), pp.884-892
Éditeur: Bmj Publishing Group
Nombre de pages: 9
Note de subvention: PI20/00800 / Instituto Carlos III; Instituto de Salud Carlos III; Spanish Government JR19/00007 / Joan Rodes contract ARSEP-1276 / Fondation pour l'aide a la recherche sur la sclerose en plaques (ARSEP) FI21/00282 / P-FIS grant
Identifiants: 99155030209311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article