Assessment of high-affinity hybridization, RNase H cleavage, and covalent linkage in translation arrest by antisense oligonucleotides

J. E. Gee; I. Robbins; A. C. van Der Laan; J. H. Van Boom; C. Colombier; M. Leng; A. M. Raible; J. S. Nelson; B. Lebleu

doi:10.1089/oli.1.1998.8.103

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Assessment of high-affinity hybridization, RNase H cleavage, and covalent linkage in translation arrest by antisense oligonucleotides

Journal article

Peer reviewed

Assessment of high-affinity hybridization, RNase H cleavage, and covalent linkage in translation arrest by antisense oligonucleotides

J. E. Gee, I. Robbins, A. C. van Der Laan, J. H. Van Boom, C. Colombier, M. Leng, A. M. Raible, J. S. Nelson and B. Lebleu

Antisense and Nucleic Acid Drug Development, Vol.8(2), pp.103--11

1998

DOI: https://doi.org/10.1089/oli.1.1998.8.103

PMID: 9593048

Abstract

Animals Cell-Free System L Cells (Cell Line) Macromolecular Substances Mice Molecular Structure Nucleic Acid Denaturation *Nucleic Acid Hybridization Nucleocapsid/*genetics *Nucleocapsid Proteins Oligonucleotides

Antisense/*pharmacology Protein Biosynthesis/*drug effects RNA

Messenger/*antagonists & inhibitors/genetics Rabbits Reticulocytes/drug effects/metabolism Ribonuclease H/*pharmacology Ribosomes/physiology Structure-Activity Relationship Temperature

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Title: Assessment of high-affinity hybridization, RNase H cleavage, and covalent linkage in translation arrest by antisense oligonucleotides
Creators - without role: J. E. Gee
I. Robbins - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
A. C. van Der Laan
J. H. Van Boom
C. Colombier
M. Leng - Université Claude Bernard Lyon 1
A. M. Raible
J. S. Nelson
B. Lebleu - Université de Montpellier, Institut de Génétique Moléculaire de Montpellier - IGMM
Publication Details: Antisense and Nucleic Acid Drug Development, Vol.8(2), pp.103--11
Identifiers: 9945994309311
Academic Unit: Institut de Génétique Moléculaire de Montpellier - IGMM
Language: English
Resource Type: Journal article
Local Fields: hal-02195847