Abstract
ORIGIN, EVOLUTION AND CONSERVATION OF THE ASP GENE……………………………………………..4 THE ANTISENSE TRANSCRIPTIONAL ACTIVITY OF HIV-1……………………………………………………..5 The antisense transcripts of HIV-1 in vitro…………………….…………………………………………………..6 The antisense transcripts of HIV-1 in vivo………………………………………………………………………….7 STRUCTURE AND SUBCELLULAR LOCALIZATION OF ASP………………………………………………….….8 Structure of ASP……………………………………………..………………………………………………………………...8 Subcellular localization of ASP…………………………………………………….…………………………………..10 ASP AND IMMUNE RESPONSE……………………………………………………………………………………….…11 FUNCTIONS OF ANTISENSE TRANSCRIPTS AND ASP IN THE LIFE CYCLE OF HIV-1………….……12