Antimicrobial lessons from a large observational cohort on intra-abdominal infections in intensive care units

Dirk Vogelaers; Stijn Blot; Andries Van den Berge; Philippe Montravers; Guy Francois; Sonia Labeau; Koen Blot; Mieke Deschepper; Massimo Antonelli; Jeffrey Lipman; Amin Lamrous; Cecilia Pereyra; Fernando Lipovestky; Despoina Koulenti; Jan De Waele; Joao Rezende-Neto; Yenny Cardenas; Tomas Vymazal; Hans Fjeldsoee-Nielsen; Matthias Kott; Arvaniti Kostoula; Yash Javeri; Massimo Girardis; Sharon Einav; Dylan de Lange; Luis Daniel Umezawa Makikado; Adam Mikstacki; José-Artur Paiva; Dana Tomescu; Alexey Gritsan; Bojan Jovanovic; Kumaresh Venkatesan; Tomislav Mirkovic; Emilio Maseda; Yalim Dikmen; Benedict Creagh-Brown; Monica Emmerich; Mariana Canale; Lorena Silvina Dietz; Santiago Ilutovich; John Thomas Sanchez Miñope; Ramona Baldomera Silva; Martin Alexis Montenegro; Patricio Martin; Pablo Saul; Viviana Chediack; Giselle Sutton; Rocio Couce; Carina Balasini; Susana Gonzalez; Florencia Maria Lascar; Emiliano Jorge Descotte; Natalia Soledad Gumiela; Carina Alejandra Pino; Cristian Cesio; Emanuel Valgolio; Eleonora Cunto; Cecilia Dominguez; Nydia Funes Nelson; Esteban Martin Abegao; Norberto Christian Pozo; Luciana Bianchi; Enrique Correger; Maria Laura Pastorino; Erica Aurora Miyazaki; Nicolas Grubissich; Mariel Garcia; Natalia Bonetto; Noelia Elizabeth Quevedo; Cristina Delia Gomez; Felipe Queti; Luis Gonzalez Estevarena; Ruben Fernandez; Ignacio Santolaya; Sergio Hugo Grangeat; Juan Doglia; Graciela Zakalik; Carlos Pellegrini; Maria Monserrat Lloria; Mercedes Esteban Chacon; Mariela Fumale; Mariela Leguizamon; Irene Beatriz Hidalgo; Roberto Julian Tiranti; Paola Capponi; Agustin Tita; Luis Cardonnet; Lisandro Bettini; Agñel Ramos; Luciano Lovesio; Edith Miriam Miranda; Angelica Beatriz Farfan; Carina Tolosa; Lise Segura; Adelina Bellocchio; Brian Alvarez; Adriana Manzur; Rodolfo Lujan; Natalia Fernandez; Nahuel Scarone; Alan Zazu; Carina Groh; Jason Fletcher; Julie Smith; Raman Azad; Nitin Chavan; Helen Wong; Mark Kol; Lewis Campbell; Therese Starr; Brigit Roberts; Bradley Wibrow; Timothy Warhurst; Meher Chinthamuneedi; Bernal Buitrago Ferney; Marc Simon; Daniel De Backer; Xavier Wittebole; David De Bels; Vincent Collin; Karolien Dams; Philippe Jorens; Jasperina Dubois; Jan Gunst; Lionel Haentjens; Nicolas De Schryver; Thierry Dugernier; Sandro Rizoli; Paul Santillan; Yi Han; Ewelina Biskup; Changjing Qu; Xinyu Li; Tao Yu; Lu Weihua; Daniel Molano-Franco; José Rojas; Juan Mauricio Pardo Oviedo; Dario Pinilla; Edgar Celis; Mario Arias; Anita Vukovic; Maja Vudrag; Matija Belavic; Josip Zunic; Janja Kuharic; Irena Bozanic Kricka; Ina Filipovic-Grcic; Boris Tomasevic; Melanija Obraz; Bruna Bodulica; Martin Dohnal; Jan Malaska; Milan Kratochvil; Igor Satinsky; Peter Schwarz; Zdenek Kos; Ladislav Blahut; Jan Maca; Marek Protus; Eva Kieslichová; Louise Gramstrup Nielsen; Birgitte Marianne Krogh; Francisco Rivadeneira; Freddy Morales; José Mora; Alexandra Saraguro Orozco; Diego Rolando MorochoTutillo; Nelson Remache Vargas; Estuardo Salgado Yepez; Boris Villamagua; Adel Alsisi; Abdelraouf Fahmy; Hervé Dupont; Sigismond Lasocki; Catherine Paugam-Burtz; Arnaud Foucrier; Alexandru Nica; Geneviève Barjon; Jihad Mallat; Guillaume Marcotte; Marc Leone; Gary Duclos; Philippe Burtin; Enora Atchade; Yazine Mahjoub; Benoît Misset; Jean-François Timsit; Claire Dupuis; Benoît Veber; Matthieu Debarre; Oliver Collange; Julien Pottecher; Stephane Hecketsweiler; Mélanie Fromentin; Antoine Tesnière; Christian Koch; Michael Sander; Christian Eckmann; Gunnar Elke; Hermann Wrigge; Philipp Simon; Anthoula Chalkiadaki; Charalampos Tzanidakis; Ioannis Pneumatikos; Eleni Sertaridou; Zafiria Mastora; Ioannis Pantazopoulos; Metaxia Papanikolaou; Theonymfi Papavasilopoulou; John Floros; Virginia Kolonia; George Dimopoulos; Chryssa Diakaki; Michael Rallis; Alexandra Paridou; Alexandros Kalogeromitros; Vasiliki Romanou; Charikleia Nikolaou; Katerina Kounougeri; Evdoxia Tsigou; Vasiliki Psallida; Niki Karampela; Konstantinos Mandragos; Eftychia Kontoudaki; Alexandra Pentheroudaki; Christos Farazi-Chongouki; Agathi Karakosta; Isaac Chouris; Vasiliki Radu; Polychronis Malliotakis; Sofia Kokkini; Eliana Charalambous; Aikaterini Kyritsi; Vasilios Koulouras; Georgios Papathanakos; Eva Nagky; Clairi Lampiri; Fotios Tsimpoukas; Ioannis Sarakatsanos; Panagiotis Georgakopoulos; Ifigeneia Ravani; Athanasios Prekates; Konstantinos Sakellaridis; Christos Christopoulos; Efstratia Vrettou; Konstantinos Stokkos; Anastasia Pentari; Kostoula Arvaniti; Kyriaki Marmanidou; Christina Kydona; Georgios Tsoumaropoulos; Militisa Bitzani; Paschalina Kontou; Antonios Voudouris; [missing] Elli-Nikki; [missing] Flioni; Elli Antypa; Eleftheria Chasou; Souzana Anisoglou; Eirini Papageorgiou; Theoniki Paraforou; Agoritsa Tsioka; Antigoni Karathanou; Aristeidis Vakalos; Bhagyesh Shah; Chirag Thakkar; Nikhilesh Jain; Mohan Gurjar; Arvind Baronia; Prachee Sathe; Shilpa Kulkarni; Cherish Paul; John Paul; Mansoor Masjedi; Reza Nikandish; Farid Zand; Golnar Sabetian; Ata Mahmoodpoor; Seyed Mohammadreza Hashemian; Miklosh Bala; Romeo Flocco; Sergio Torrente; Vincenzo Pota; Savino Spadaro; Carlo Volta; Giulia Serafini; Sabrina Boraso; Ivo Tiberio; Andrea Cortegiani; Giovanni Misseri; Maria Barbagallo; Davide Nicolotti; Francesco Forfori; Francesco Corradi; Gennaro De Pascale; Lorella Pelagalli; Luca Brazzi; Ferdinando Giorgio Vittone; Alessandro Russo; Davide Simion; Antonella Cotoia; Gilda Cinnella; Patrick Toppin; Roxanne Johnson-Jackson; Yoshiro Hayashi; Ryohei Yamamoto; Hideto Yasuda; Yuki Kishihara; Junji Shiotsuka; Luis Alejandro Sanchez-Hurtado; Brigitte Tejeda-Huezo; Luis Gorordo; Silvio A Ñamendys-Silva; Francisco J Garcia-Guillen; Manuel Martinez; Erick Romero-Meja; Ever Colorado-Dominguez; Huub van den Oever; Karel Martijn Kalff; Wytze Vermeijden; Alexander Daniel Cornet; Oliver Beck; Nedim Cimic; Tom Dormans; Laura Bormans; Jan Bakker; Ditty Van Duijn; Gerrit Bosman; Piet Vos; Lenneke Haas; Akram Henein; Ariel M Miranda; Gonzalo Ernesto Gianella Malca; Abel Arroyo-Sanchez; Agnieszka Misiewska-Kaczur; Frisch Akinyi; Miroslaw Czuczwar; Karolina Luczak; Wiktor Sulkowski; Barbara Tamowicz; Beata Swit; Bronisław Baranowski; Piotr Smuszkiewicz; Iwona Trojanowska; Stanislaw Rzymski; Mariusz Sawinski; Marta Trosiak; Malgorzata Mikaszewska-Sokolewicz; Ricardo Alves; Dina Leal; Andriy Krystopchuk; Pedro Muguel Hilario Mendonca; Rui Antunes Pereira; Maria Raquel Lopes Marques de Carvalho; Carlos Candeias; Elena Molinos; Amélia Ferreira; Guiomar Castro; José-Manuel Pereira; Lurdes Santos; Alcina Ferreira; Dulce Pascoalinho; Rosa Ribeiro; Guilherme Domingos; Pedro Gomes; David Nora; Rui Pedro Costa; Anabela Santos; Ahmed Subhy Alsheikhly; Mihai Popescu; Ioana Grigoras; Emilia Patrascanu; Igor Zabolotskikh; Tatiana Musaeva; Denis Gaigolnik; Vladimir Kulabukhov; Vladislav Belskiy; Nadezhda Zubareva; Maxim Tribulev; Ahmed Abdelsalam; Ayman Aldarsani; Muhammad Al-Khalid; Ghaleb Almekhlafi; Yasser Mandourah; Krstina Doklestic; Jelena Velickovic; Dejan Velickovic; Radmilo Jankovic; Svetlana Skoric-Jokic; Dragana Radovanovic; Guy Richards; Ahmad Alli; Maria Del Carmen Cordoba Nielfa; Rafael Sánchez Iniesta; Adela Benítez-Cano Martínez; Carlos Garcia Bernedo; Santiago Alberto Picos Gil; Xavier Nuvials; Jordi Rello; Joseba Gonzalez Garcia; Jose Manuel Garcia Peña; Roberto Jimenez; Luis Herrera; Laura Galarza Barrachina; Ignacio Catalan Monzon; Francisco Javier Redondo; Ruben Villazala; Diego Fernando Matallana Zapata; Isabel Maria Villa Lopez; Gabriel Moreno-Gonzalez; Juan Carlos Lopez-Delgado; Jorge Solera Marin; Purificacion Sanchez-Zamora; Montserrat Vallverdú Vidal; Jesús Flores González; Irene Salinas; Cecilia Hermosa; Fernando Martinez-Sagasti; Sara Domingo-Marín; Johanna Abril Victorino; Raquel Garcia-Alvarez; Pablo López-Arcas Calleja; Maria-Victoria de la Torre-Prados; Pablo Vidal-Cortes; Lorena Del Río-Carbajo; Javier Izura; Victoria Minguez; Josep Trenado Alvarez; Anna Parera Prous; Daniel Paz; Ferran Roche-Campo; Gerardo Aguilar; Javier Belda; Jesus Rico-Feijoo; Cesat Aldecoa; Begoña Zalba-Etayo; Martin Lang; Alexander Dullenkopf; Konlawij Trongtrakul; Anusang Chtsomkasem; Türkay Akbaş; Mustafa Necmettin Unal; Menekse Ozcelik; Ayca Gumus; Atilla Ramazanoglu; Dilek Memis; Inal Mehmet; Seval Urkmez; Asu Ozgultekin; Oktay Demirkiran; Nesrin Ahu Aslan; Deniz Kizilaslan; Ferda Kahveci; Nurdan Ünlü; Zeynep Ozkan; Callum Kaye; Jan Jansen; Orla O’Neill; Christopher Nutt; Rajeev Jha; Nicolas Hooker; Irina Grecu; Christina Petridou; Murali Shyamsundar; Lia McNamee; John Trinder; Samantha Hagan; Catriona Kelly; Jonathon Silversides; Casiano Barrera Groba; Owen Boyd; Kaushik Bhowmick; Sally Humphreys; Charlotte Summers; Petra Polgarova; Michael Margarson; Justin Dickens; Suzanne Pearson; Elaine Chinery; Noel Hemmings; Sinead O’Kane; Pauline Austin; Stephen Cole; Catherine Plowright; Roberta Box; Christopher Wright; Lorna Young; Ben Creagh-Brown; Laura Montague; Robert Parker; Ben Morton; Marlies Ostermann; Julia Bilinska; Bernd Oliver Rose; Rosie Reece-Anthony; Christine Ryan; Mark Hamilton; Philip Hopkins; Julia Wendon; Giovanni Brescia; Nazia Ijaz; James Wood; Michelle George; Piroska Toth-Tarsoly; Bryan Yates; Maureen Armstrong; Carmen Scott; Christine Boyd; Tamas Szakmany; David Rees; Paul Pulak; Mandy Coggon; Bhaskar Saha; Linda Kent; Bethan Gibson; Julie Camsooksai; Henrik Reschreiter; Pat Morgan; Sivatharshini Sangaralingham; Alastair Lowe; Petr Vondras; Sunil Jamadarkhana; Carina Cruz; Rakesh Bhandary; Peter Hersey; Julie Furneval; Richard Innes; Patricia Doble; Ben Attwood; Penny Parsons; Valerie Page; Xiaobei Zhao; Julian Dalton; Mohammed Hegazy; Yasser Awad; Douglas Naylor; Amanda Naylor; Sarah Lee; Sidney Brevard; Noelle Davis; [missing] for the Abdominal Sepsis Study Group on behalf of the Trials Group of the European Society of Intensive Care Medicine

Antimicrobial lessons from a large observational cohort on intra-abdominal infections in intensive care units

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Antimicrobial lessons from a large observational cohort on intra-abdominal infections in intensive care units

Dirk Vogelaers, Stijn Blot, Andries Van den Berge, Philippe Montravers, Guy Francois, Sonia Labeau, Koen Blot, Mieke Deschepper, Massimo Antonelli, Jeffrey Lipman, …

2021

Résumé

BLOOD-STREAM INFECTIONS

ENTEROBACTERIACEAE

ESCHERICHIA-COLI

FLUOROQUINOLONE RESISTANCE

FOOD

KLEBSIELLA-PNEUMONIAE

Medicine and Health Sciences

MORTALITY

PERITONITIS

Pharmacology (medical)

PYELONEPHRITIS

RISK-FACTORS

Severe intra-abdominal infection commonly requires intensive care. Mortality is high and is mainly determined by disease-specific characteristics, i.e. setting of infection onset, anatomical barrier disruption, and severity of disease expression. Recent observations revealed that antimicrobial resistance appears equally common in community-acquired and late-onset hospital-acquired infection. This challenges basic principles in anti-infective therapy guidelines, including the paradigm that pathogens involved in community-acquired infection are covered by standard empiric antimicrobial regimens, and second, the concept of nosocomial acquisition as the main driver for resistance involvement. In this study, we report on resistance profiles of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecalis and Enterococcus faecium in distinct European geographic regions based on an observational cohort study on intra-abdominal infections in intensive care unit (ICU) patients. Resistance against aminopenicillins, fluoroquinolones, and third-generation cephalosporins in E. coli, K. pneumoniae and P. aeruginosa is problematic, as is carbapenem-resistance in the latter pathogen. For E. coli and K. pneumoniae, resistance is mainly an issue in Central Europe, Eastern and South-East Europe, and Southern Europe, while resistance in P. aeruginosa is additionally problematic in Western Europe. Vancomycin-resistance in E. faecalis is of lesser concern but requires vigilance in E. faecium in Central and Eastern and South-East Europe. In the subcohort of patients with secondary peritonitis presenting with either sepsis or septic shock, the appropriateness of empiric antimicrobial therapy was not associated with mortality. In contrast, failure of source control was strongly associated with mortality. The relevance of these new insights for future recommendations regarding empiric antimicrobial therapy in intra-abdominal infections is discussed.

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Titre: Antimicrobial lessons from a large observational cohort on intra-abdominal infections in intensive care units
Créateurs - sans rôle: Dirk Vogelaers
Stijn Blot
Andries Van den Berge
Philippe Montravers
Guy Francois
Sonia Labeau
Koen Blot
Mieke Deschepper
Massimo Antonelli
Jeffrey Lipman
Amin Lamrous
Cecilia Pereyra
Fernando Lipovestky
Despoina Koulenti
Jan De Waele
Joao Rezende-Neto
Yenny Cardenas
Tomas Vymazal
Hans Fjeldsoee-Nielsen
Matthias Kott
Arvaniti Kostoula
Yash Javeri
Massimo Girardis
Sharon Einav
Dylan de Lange
Luis Daniel Umezawa Makikado
Adam Mikstacki
José-Artur Paiva
Dana Tomescu
Alexey Gritsan
Bojan Jovanovic
Kumaresh Venkatesan
Tomislav Mirkovic
Emilio Maseda
Yalim Dikmen
Benedict Creagh-Brown
Monica Emmerich
Mariana Canale
Lorena Silvina Dietz
Santiago Ilutovich
John Thomas Sanchez Miñope
Ramona Baldomera Silva
Martin Alexis Montenegro
Patricio Martin
Pablo Saul
Viviana Chediack
Giselle Sutton
Rocio Couce
Carina Balasini
Susana Gonzalez
Florencia Maria Lascar
Emiliano Jorge Descotte
Natalia Soledad Gumiela
Carina Alejandra Pino
Cristian Cesio
Emanuel Valgolio
Eleonora Cunto
Cecilia Dominguez
Nydia Funes Nelson
Esteban Martin Abegao
Norberto Christian Pozo
Luciana Bianchi
Enrique Correger
Maria Laura Pastorino
Erica Aurora Miyazaki
Nicolas Grubissich
Mariel Garcia
Natalia Bonetto
Noelia Elizabeth Quevedo
Cristina Delia Gomez
Felipe Queti
Luis Gonzalez Estevarena
Ruben Fernandez
Ignacio Santolaya
Sergio Hugo Grangeat
Juan Doglia
Graciela Zakalik
Carlos Pellegrini
Maria Monserrat Lloria
Mercedes Esteban Chacon
Mariela Fumale
Mariela Leguizamon
Irene Beatriz Hidalgo
Roberto Julian Tiranti
Paola Capponi
Agustin Tita
Luis Cardonnet
Lisandro Bettini
Agñel Ramos
Luciano Lovesio
Edith Miriam Miranda
Angelica Beatriz Farfan
Carina Tolosa
Lise Segura
Adelina Bellocchio
Brian Alvarez
Adriana Manzur
Rodolfo Lujan
Natalia Fernandez
Nahuel Scarone
Alan Zazu
Carina Groh
Jason Fletcher
Julie Smith
Raman Azad
Nitin Chavan
Helen Wong
Mark Kol
Lewis Campbell
Therese Starr
Brigit Roberts
Bradley Wibrow
Timothy Warhurst
Meher Chinthamuneedi
Bernal Buitrago Ferney
Marc Simon
Daniel De Backer
Xavier Wittebole
David De Bels
Vincent Collin
Karolien Dams
Philippe Jorens
Jasperina Dubois
Jan Gunst
Lionel Haentjens
Nicolas De Schryver
Thierry Dugernier
Sandro Rizoli
Paul Santillan
Yi Han
Ewelina Biskup
Changjing Qu
Xinyu Li
Tao Yu
Lu Weihua
Daniel Molano-Franco
José Rojas
Juan Mauricio Pardo Oviedo
Dario Pinilla
Edgar Celis
Mario Arias
Anita Vukovic
Maja Vudrag
Matija Belavic
Josip Zunic
Janja Kuharic
Irena Bozanic Kricka
Ina Filipovic-Grcic
Boris Tomasevic
Melanija Obraz
Bruna Bodulica
Martin Dohnal
Jan Malaska
Milan Kratochvil
Igor Satinsky
Peter Schwarz
Zdenek Kos
Ladislav Blahut
Jan Maca
Marek Protus
Eva Kieslichová
Louise Gramstrup Nielsen
Birgitte Marianne Krogh
Francisco Rivadeneira
Freddy Morales
José Mora
Alexandra Saraguro Orozco
Diego Rolando MorochoTutillo
Nelson Remache Vargas
Estuardo Salgado Yepez
Boris Villamagua
Adel Alsisi
Abdelraouf Fahmy
Hervé Dupont
Sigismond Lasocki
Catherine Paugam-Burtz
Arnaud Foucrier
Alexandru Nica
Geneviève Barjon
Jihad Mallat
Guillaume Marcotte
Marc Leone
Gary Duclos
Philippe Burtin
Enora Atchade
Yazine Mahjoub
Benoît Misset
Jean-François Timsit
Claire Dupuis
Benoît Veber
Matthieu Debarre
Oliver Collange
Julien Pottecher
Stephane Hecketsweiler
Mélanie Fromentin
Antoine Tesnière
Christian Koch
Michael Sander
Christian Eckmann
Gunnar Elke
Hermann Wrigge
Philipp Simon
Anthoula Chalkiadaki
Charalampos Tzanidakis
Ioannis Pneumatikos
Eleni Sertaridou
Zafiria Mastora
Ioannis Pantazopoulos
Metaxia Papanikolaou
Theonymfi Papavasilopoulou
John Floros
Virginia Kolonia
George Dimopoulos
Chryssa Diakaki
Michael Rallis
Alexandra Paridou
Alexandros Kalogeromitros
Vasiliki Romanou
Charikleia Nikolaou
Katerina Kounougeri
Evdoxia Tsigou
Vasiliki Psallida
Niki Karampela
Konstantinos Mandragos
Eftychia Kontoudaki
Alexandra Pentheroudaki
Christos Farazi-Chongouki
Agathi Karakosta
Isaac Chouris
Vasiliki Radu
Polychronis Malliotakis
Sofia Kokkini
Eliana Charalambous
Aikaterini Kyritsi
Vasilios Koulouras
Georgios Papathanakos
Eva Nagky
Clairi Lampiri
Fotios Tsimpoukas
Ioannis Sarakatsanos
Panagiotis Georgakopoulos
Ifigeneia Ravani
Athanasios Prekates
Konstantinos Sakellaridis
Christos Christopoulos
Efstratia Vrettou
Konstantinos Stokkos
Anastasia Pentari
Kostoula Arvaniti
Kyriaki Marmanidou
Christina Kydona
Georgios Tsoumaropoulos
Militisa Bitzani
Paschalina Kontou
Antonios Voudouris
[missing] Elli-Nikki
[missing] Flioni
Elli Antypa
Eleftheria Chasou
Souzana Anisoglou
Eirini Papageorgiou
Theoniki Paraforou
Agoritsa Tsioka
Antigoni Karathanou
Aristeidis Vakalos
Bhagyesh Shah
Chirag Thakkar
Nikhilesh Jain
Mohan Gurjar
Arvind Baronia
Prachee Sathe
Shilpa Kulkarni
Cherish Paul
John Paul
Mansoor Masjedi
Reza Nikandish
Farid Zand
Golnar Sabetian
Ata Mahmoodpoor
Seyed Mohammadreza Hashemian
Miklosh Bala
Romeo Flocco
Sergio Torrente
Vincenzo Pota
Savino Spadaro
Carlo Volta
Giulia Serafini
Sabrina Boraso
Ivo Tiberio
Andrea Cortegiani
Giovanni Misseri
Maria Barbagallo
Davide Nicolotti
Francesco Forfori
Francesco Corradi
Gennaro De Pascale
Lorella Pelagalli
Luca Brazzi
Ferdinando Giorgio Vittone
Alessandro Russo
Davide Simion
Antonella Cotoia
Gilda Cinnella
Patrick Toppin
Roxanne Johnson-Jackson
Yoshiro Hayashi
Ryohei Yamamoto
Hideto Yasuda
Yuki Kishihara
Junji Shiotsuka
Luis Alejandro Sanchez-Hurtado
Brigitte Tejeda-Huezo
Luis Gorordo
Silvio A Ñamendys-Silva
Francisco J Garcia-Guillen
Manuel Martinez
Erick Romero-Meja
Ever Colorado-Dominguez
Huub van den Oever
Karel Martijn Kalff
Wytze Vermeijden
Alexander Daniel Cornet
Oliver Beck
Nedim Cimic
Tom Dormans
Laura Bormans
Jan Bakker
Ditty Van Duijn
Gerrit Bosman
Piet Vos
Lenneke Haas
Akram Henein
Ariel M Miranda
Gonzalo Ernesto Gianella Malca
Abel Arroyo-Sanchez
Agnieszka Misiewska-Kaczur
Frisch Akinyi
Miroslaw Czuczwar
Karolina Luczak
Wiktor Sulkowski
Barbara Tamowicz
Beata Swit
Bronisław Baranowski
Piotr Smuszkiewicz
Iwona Trojanowska
Stanislaw Rzymski
Mariusz Sawinski
Marta Trosiak
Malgorzata Mikaszewska-Sokolewicz
Ricardo Alves
Dina Leal
Andriy Krystopchuk
Pedro Muguel Hilario Mendonca
Rui Antunes Pereira
Maria Raquel Lopes Marques de Carvalho
Carlos Candeias
Elena Molinos
Amélia Ferreira
Guiomar Castro
José-Manuel Pereira
Lurdes Santos
Alcina Ferreira
Dulce Pascoalinho
Rosa Ribeiro
Guilherme Domingos
Pedro Gomes
David Nora
Rui Pedro Costa
Anabela Santos
Ahmed Subhy Alsheikhly
Mihai Popescu
Ioana Grigoras
Emilia Patrascanu
Igor Zabolotskikh
Tatiana Musaeva
Denis Gaigolnik
Vladimir Kulabukhov
Vladislav Belskiy
Nadezhda Zubareva
Maxim Tribulev
Ahmed Abdelsalam
Ayman Aldarsani
Muhammad Al-Khalid
Ghaleb Almekhlafi
Yasser Mandourah
Krstina Doklestic
Jelena Velickovic
Dejan Velickovic
Radmilo Jankovic
Svetlana Skoric-Jokic
Dragana Radovanovic
Guy Richards
Ahmad Alli
Maria Del Carmen Cordoba Nielfa
Rafael Sánchez Iniesta
Adela Benítez-Cano Martínez
Carlos Garcia Bernedo
Santiago Alberto Picos Gil
Xavier Nuvials
Jordi Rello
Joseba Gonzalez Garcia
Jose Manuel Garcia Peña
Roberto Jimenez
Luis Herrera
Laura Galarza Barrachina
Ignacio Catalan Monzon
Francisco Javier Redondo
Ruben Villazala
Diego Fernando Matallana Zapata
Isabel Maria Villa Lopez
Gabriel Moreno-Gonzalez
Juan Carlos Lopez-Delgado
Jorge Solera Marin
Purificacion Sanchez-Zamora
Montserrat Vallverdú Vidal
Jesús Flores González
Irene Salinas
Cecilia Hermosa
Fernando Martinez-Sagasti
Sara Domingo-Marín
Johanna Abril Victorino
Raquel Garcia-Alvarez
Pablo López-Arcas Calleja
Maria-Victoria de la Torre-Prados
Pablo Vidal-Cortes
Lorena Del Río-Carbajo
Javier Izura
Victoria Minguez
Josep Trenado Alvarez
Anna Parera Prous
Daniel Paz
Ferran Roche-Campo
Gerardo Aguilar
Javier Belda
Jesus Rico-Feijoo
Cesat Aldecoa
Begoña Zalba-Etayo
Martin Lang
Alexander Dullenkopf
Konlawij Trongtrakul
Anusang Chtsomkasem
Türkay Akbaş
Mustafa Necmettin Unal
Menekse Ozcelik
Ayca Gumus
Atilla Ramazanoglu
Dilek Memis
Inal Mehmet
Seval Urkmez
Asu Ozgultekin
Oktay Demirkiran
Nesrin Ahu Aslan
Deniz Kizilaslan
Ferda Kahveci
Nurdan Ünlü
Zeynep Ozkan
Callum Kaye
Jan Jansen
Orla O’Neill
Christopher Nutt
Rajeev Jha
Nicolas Hooker
Irina Grecu
Christina Petridou
Murali Shyamsundar
Lia McNamee
John Trinder
Samantha Hagan
Catriona Kelly
Jonathon Silversides
Casiano Barrera Groba
Owen Boyd
Kaushik Bhowmick
Sally Humphreys
Charlotte Summers
Petra Polgarova
Michael Margarson
Justin Dickens
Suzanne Pearson
Elaine Chinery
Noel Hemmings
Sinead O’Kane
Pauline Austin
Stephen Cole
Catherine Plowright
Roberta Box
Christopher Wright
Lorna Young
Ben Creagh-Brown
Laura Montague
Robert Parker
Ben Morton
Marlies Ostermann
Julia Bilinska
Bernd Oliver Rose
Rosie Reece-Anthony
Christine Ryan
Mark Hamilton
Philip Hopkins
Julia Wendon
Giovanni Brescia
Nazia Ijaz
James Wood
Michelle George
Piroska Toth-Tarsoly
Bryan Yates
Maureen Armstrong
Carmen Scott
Christine Boyd
Tamas Szakmany
David Rees
Paul Pulak
Mandy Coggon
Bhaskar Saha
Linda Kent
Bethan Gibson
Julie Camsooksai
Henrik Reschreiter
Pat Morgan
Sivatharshini Sangaralingham
Alastair Lowe
Petr Vondras
Sunil Jamadarkhana
Carina Cruz
Rakesh Bhandary
Peter Hersey
Julie Furneval
Richard Innes
Patricia Doble
Ben Attwood
Penny Parsons
Valerie Page
Xiaobei Zhao
Julian Dalton
Mohammed Hegazy
Yasser Awad
Douglas Naylor
Amanda Naylor
Sarah Lee
Sidney Brevard
Noelle Davis
[missing] for the Abdominal Sepsis Study Group on behalf of the Trials Group of the European Society of Intensive Care Medicine
Identifiants: 99153964309311
Unité académique: Initial MAnagement & prevent of acute orGan failures IN critically ill patiEnts - IMAGINE
Langue: English
Type de ressource: Journal article