Résumé
β-
l-2′,3′-Dideoxyadenosine, β-
l-2′,3′-didehydro-2′,3′-dideoxyadenosine and related compounds were synthesized in a stereoselective manner. These compounds were tested in vitro against HBV in 2.2.15 cell line and against HIV-1 in PBM and CEM cells. It was found that β-
l-2′,3′-dideohydro-2′,3′-dideoxyadenosine (
7) exhibited significant anti-HIV (EC
50 0.38 μM in PBM cells) and anti-HBV activity (EC
50 1.2 μM).
β-L-2′,3′-Dideoxyadenosine, β-L-2′,3′-didehydro-2′,3′-dideoxyadenosine and related compounds were synthesized in a stereoselective manner. β-L-2′,3′-didehydro-2′,3′-dideoxyadenosine (
7) exhibited significant anti-HIV (EC
50 0.38 μM in PBM cells) and anti-HBV (EC
50 1.2 μM in 2.2.15 cells) activities.