Résumé
We report the anti-Chagasic activity of the natural dihydrostilbenoid isonotholaenic acid and several simple derivatives, as well as that of some representative compounds of related synthetic series, with basic structures of benzalphthalides, dihydrostilbamides, isoindoles, phthalazin-1-ones, imidazo[2,1
-a]isoindoles and pyrimido[2,1
-a]isoindoles. The evaluation was performed in vitro on cultures of epimastigote and trypomastigote forms of
Trypanosoma cruzi. Some of the tested compounds resulted to be as potent as benznidazole (epimastigotes), and others were shown to be more active than gentian violet (trypomastigotes), used as reference drugs.
The natural dihydrostilbene isonotholaenic acid, semi-synthetic derivatives and total synthetic analogues, displaying benzalphthalide, dihydrostilbamide, phthalazinone, and imidazo/pyrimido-isoindole structures, have been obtained and tested on anti-trypanosome assays.