Anti-PrP antibodies block PrPSc replication in prion-infected cell cultures by accelerating PrPC degradation.

Journal article

Open access

Peer reviewed

Véronique Perrier, Jérôme Solassol, Carole Crozet, Yveline Frobert, Chantal Mourton-Gilles, Jacques Grassi and Sylvain Lehmann

Journal of Neurochemistry, Vol.89(2), pp.454-63

04/2004

PMCID: PMC2063508

PMID: 15056288

Abstract

antibodies mechanism and therapeutic

anti-prion agent

prion diseases

Animals

Antibodies, Monoclonal

Neuroblastoma

PrPC Proteins

PrPSc Proteins

Prion Diseases

Cell Line, Tumor

Dose-Response Relationship, Drug

Drug Evaluation, Preclinical

Drug Synergism

Humans

Mice

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Title: Anti-PrP antibodies block PrPSc replication in prion-infected cell cultures by accelerating PrPC degradation.
Creators - without role: Véronique Perrier - Université de Montpellier, Institut de Génétique Humaine - IGH
Jérôme Solassol - Université de Montpellier, Institut de Génétique Humaine - IGH
Carole Crozet - Université de Montpellier, Institut de Génétique Humaine - IGH
Yveline Frobert - CEA Paris-Saclay
Chantal Mourton-Gilles - Centre National de la Recherche Scientifique
Jacques Grassi - Commissariat à l'Énergie Atomique et aux Énergies Alternatives
Sylvain Lehmann - Université de Montpellier, Institut de Génétique Humaine - IGH
Publication Details: Journal of Neurochemistry, Vol.89(2), pp.454-63
Identifiers: 9934641009311
Academic Unit: Institut de Recherche en Cancérologie de Montpellier - IRCM; Institut des Neurosciences de Montpellier - INM; Institut de Génétique Humaine - IGH
Language: English
Resource Type: Journal article
Local Fields: inserm-00143226