Anti-BP180 IgG antibody ELISA values correlate with adverse pregnancy outcomes in pemphigoid gestationis

Nadège Cordel; Jasmine Flament; Fabienne Jouen; Vannina Seta; Emmanuelle Tancrède-Bohin; Catherine Picard Dahan; Maria-Polina Konstantinou; Olivier Dereure; Gaëlle Quéreux; Catherine Prost; Christophe Bedane; Sébastien Debarbieux; Jean-Philippe Lacour; Anne Dompmartin; Ewa Wierzbicka-Hainaut; Isabelle Bourgault Villada; Saskia Ingen Housz Oro; Pierre Vabres; Marie-Aleth Richard; Emmanuel Delaporte; Anne Pham-Ledard; Marie-Thérèse Leccia; Noémie Litrowski; Catherine Michel; Brigitte Lagrange; Michel D'Incan; Claire Abasq; Sophie Duvert-Lehembre; Alain Dupuy; Isabelle Alcaraz; Anne-Laure Breton-Guitarian; Florian Lombart; Eric Estève; Laurent Machet; Pascal Del Giudice; Marion Fenot; Thibaut Belmondo; Florence Morin; Olivia Guérin; Jacques Benichou; Benoît Tressières; Pascal Joly; French study Group on autoimmune bullous skin diseases

doi:10.1111/jdv.18973

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Anti-BP180 IgG antibody ELISA values correlate with adverse pregnancy outcomes in pemphigoid gestationis

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Anti-BP180 IgG antibody ELISA values correlate with adverse pregnancy outcomes in pemphigoid gestationis

Nadège Cordel, Jasmine Flament, Fabienne Jouen, Vannina Seta, Emmanuelle Tancrède-Bohin, Catherine Picard Dahan, Maria-Polina Konstantinou, Olivier Dereure, Gaëlle Quéreux, Catherine Prost, …

Journal of the European Academy of Dermatology and Venereology, Vol.37(6), pp.1207-1214

06/2023

DOI: https://doi.org/10.1111/jdv.18973

PMID: 36802102

Résumé

Autoantibodies

Autoantigens

Blister

Enzyme-Linked Immunosorbent Assay

Female

Humans

Immunoglobulin G

Infant, Newborn

Non-Fibrillar Collagens

Pemphigoid Gestationis - diagnosis

Pemphigoid, Bullous - diagnosis

Pregnancy

Pregnancy Outcome

Premature Birth

Retrospective Studies

Adverse pregnancy outcomes (APO) occur in 35% of patients with pemphigoid gestationis (PG). No biological predictor of APO has been established yet. To assess a potential relationship between the occurrence of APO and the serum value of anti-BP180 antibodies at the time of PG diagnosis. Multicentre retrospective study conducted from January 2009 to December 2019 in 35 secondary and tertiary care centres. (i) diagnosis of PG according to clinical, histological and immunological criteria, (ii) ELISA measurement of anti-BP180 IgG antibodies determined at the time of PG diagnosis with the same commercial kit and (iii) obstetrical data available. Of the 95 patients with PG included, 42 had one or more APO, which mainly corresponded to preterm birth (n = 26), intrauterine growth restriction (IUGR) (n = 18) and small weight for gestational age at birth (n = 16). From a ROC curve, we identified a threshold of 150 IU ELISA value as the most discriminating to differentiate between patients with or without IUGR, with 78% sensitivity, 55% specificity, 30% positive and 91% negative predictive value. The threshold >150 IU was confirmed using a cross-validation based on bootstrap resampling, which showed that the median threshold was 159 IU. Upon adjusting for oral corticosteroid intake and main clinical predictors of APO, an ELISA value of >150 IU was associated with the occurrence of IUGR (OR = 5.11; 95% CI: 1.48-22.30; p = 0.016) but not with any other APO. The combination of blisters and ELISA values higher than 150 IU led to a 2.4-fold higher risk of all-cause APO (OR: 10.90; 95% CI: 2.33-82.3) relative to patients with blisters but lower values of anti-BP180 antibodies (OR of 4.54; 95% CI 0.92-34.2). These findings suggest that anti-BP180 antibody ELISA value in combination with clinical markers is helpful in managing the risk of APO, in particular IUGR, in patients with PG.

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Titre: Anti-BP180 IgG antibody ELISA values correlate with adverse pregnancy outcomes in pemphigoid gestationis
Créateurs - sans rôle: Nadège Cordel - Univ Rouen Normandie, FOCIS Center of Excellence PAn'THER, Rouen, France
Jasmine Flament - Department of Dermatology, Rouen University Hospital, Rouen, France
Fabienne Jouen - Department of Immunology and biotherapies, Rouen University Hospital, Rouen, France
Vannina Seta - Assistance Publique – Hôpitaux de Paris
Emmanuelle Tancrède-Bohin - Assistance Publique – Hôpitaux de Paris
Catherine Picard Dahan - Department of Dermatology, Bichat Hospital AP-HP, Paris, France
Maria-Polina Konstantinou - Department of Dermatology, Toulouse University Hospital, Toulouse, France
Olivier Dereure - Department of Dermatology, Saint-Eloi University Hospital, Montpellier, France
Gaëlle Quéreux - Department of Dermatology, Nantes University Hospital, Nantes, France
Catherine Prost - Assistance Publique – Hôpitaux de Paris
Christophe Bedane - Department of Dermatology, Limoges University Hospital, Limoges, France
Sébastien Debarbieux - Department of Dermatology, Hôtel Dieu Hospital, Lyon, France
Jean-Philippe Lacour - Department of Dermatology, University Hospital of Nice, Nice, France
Anne Dompmartin - Department of Dermatology, Caen University Hospital, Caen, France
Ewa Wierzbicka-Hainaut - Department of Dermatology, Poitiers University Hospital, Poitiers, France
Isabelle Bourgault Villada - Department of Dermatology, Ambroise Paré Hospital, AP-HP, Boulogne-Billancourt, France
Saskia Ingen Housz Oro - Department of Dermatology, Henri Mondor Hospital, AP-HP and Univ Paris Est Créteil, EpidermE, Créteil, France
Pierre Vabres - Department of Dermatology, Dijon University Hospital, Dijon, France
Marie-Aleth Richard - Department of Dermatology, La Timone University Hospital APHM, Marseille, France
Emmanuel Delaporte - Department of Dermatology, UMR 7268 and North University Hospital APHM, Marseille, France
Anne Pham-Ledard - Department of Dermatology, University Hospital of Bordeaux, Saint-André Hospital, Bordeaux, France
Marie-Thérèse Leccia - Department of Dermatology, Allergology and Photobiology, Grenoble University Hospital, Grenoble, France
Noémie Litrowski - Department of Dermatology, Monod General Hospital, Le Havre, France
Catherine Michel - Department of Dermatology, Emile Muller Hospital, Mulhouse, France
Brigitte Lagrange - Department of Dermatology, Henri-Duffaut Hospital, Avignon, France
Michel D'Incan - Department of Dermatology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France
Claire Abasq - Department of Dermatology, Brest University Hospital, Brest, France
Sophie Duvert-Lehembre - Department of Dermatology, Dunkerque Hospital, Dunkerque, France
Alain Dupuy - Department of Dermatology, Rennes University Hospital, Rennes, France
Isabelle Alcaraz - Department of Infectious diseases and Travel, Gustave Dron Hospital, Tourcoing, France
Anne-Laure Breton-Guitarian - Department of Dermatology, Saint-Luc Saint-Joseph Hospital, Lyon, France
Florian Lombart - Department of Dermatology, Amiens University Hospital, Amiens, France
Eric Estève - Department of Dermatology, Orléans Regional Hospital, Orléans, France
Laurent Machet - Department of Dermatology, Tours University Hospital, Tours, France
Pascal Del Giudice - Infectiology-Dermatology Unit, Intercommunal Hospital of Fréjus Saint Raphaël, Fréjus, France
Marion Fenot - Department of Dermatology, Departmental Hospital of Vendée, La Roche-sur-Yon, France
Thibaut Belmondo - Assistance Publique – Hôpitaux de Paris
Florence Morin - Department of Immunology, Saint-Louis Hospital AP-HP, Paris, France
Olivia Guérin - Department of Biostatistics, Rouen University Hospital
Jacques Benichou - Bordeaux Population Health
Benoît Tressières - Centre d'Investigation Clinique Antilles Guyane, INSERM CIC 1424, Pointe-à-Pitre, Guadeloupe
Pascal Joly - Department of Dermatology, Rouen University Hospital, Rouen, France
French study Group on autoimmune bullous skin diseases
Détails de publication: Journal of the European Academy of Dermatology and Venereology, Vol.37(6), pp.1207-1214
Identifiants: 99157072509311
Unité académique: Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Langue: English
Type de ressource: Journal article