Anopheles gambiae APL1 Is a Family of Variable LRR Proteins Required for Rel1-Mediated Protection from the Malaria Parasite, Plasmodium berghei

Michelle M Riehle; Jiannong Xu; Brian P Lazzaro; Susan M Rottschaefer; Boubacar Coulibaly; Madjou Sacko; Oumou Niare; Isabelle Morlais; Sekou F Traore; Kenneth Vernick

doi:10.1371/journal.pone.0003672

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Anopheles gambiae APL1 Is a Family of Variable LRR Proteins Required for Rel1-Mediated Protection from the Malaria Parasite, Plasmodium berghei

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Anopheles gambiae APL1 Is a Family of Variable LRR Proteins Required for Rel1-Mediated Protection from the Malaria Parasite, Plasmodium berghei

Michelle M Riehle, Jiannong Xu, Brian P Lazzaro, Susan M Rottschaefer, Boubacar Coulibaly, Madjou Sacko, Oumou Niare, Isabelle Morlais, Sekou F Traore and Kenneth Vernick

PLoS ONE, Vol.3(11)

07/11/2008

DOI: https://doi.org/10.1371/journal.pone.0003672

PMCID: PMC2577063

PMID: 18989366

Abstract

Animals

Anopheles

Base Sequence

Genes, Insect

Haplotypes

Insect Proteins

Molecular Sequence Data

Plasmodium berghei

Transcription Factors

We previously identified by genetic mapping an Anopheles gambiae chromosome region with strong influence over the outcome of malaria parasite infection in nature. Candidate gene studies in the genetic interval, including functional tests using the rodent malaria parasite Plasmodium berghei, identified a novel leucine-rich repeat gene, APL1, with functional activity against P. berghei.

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Title: Anopheles gambiae APL1 Is a Family of Variable LRR Proteins Required for Rel1-Mediated Protection from the Malaria Parasite, Plasmodium berghei
Creators - without role: Michelle M Riehle - University of Minnesota
Jiannong Xu - University of Minnesota
Brian P Lazzaro - Cornell University
Susan M Rottschaefer - Cornell University
Boubacar Coulibaly - University of Bamako
Madjou Sacko - University of Bamako
Oumou Niare - University of Bamako
Isabelle Morlais - Université de Montpellier, Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Sekou F Traore - University of Bamako
Kenneth Vernick - University of Minnesota
Publication Details: PLoS ONE, Vol.3(11)
Identifiers: 9946324409311
Academic Unit: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Language: English
Resource Type: Journal article
Local Fields: hal-03040503