Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Latha Kadalayil; Md Zahangir Alam; Cory Haley White; Akram Ghantous; Esther Walton; Olena Gruzieva; Simon Kebede Merid; Ashish Kumar; Ritu P Roy; Olivia Solomon; Karen Huen; Brenda Eskenazi; Peter Rzehak; Veit Grote; Jean-Paul Langhendries; Elvira Verduci; Natalia Ferre; Darek Gruszfeld; Lu Gao; Weihua Guan; Xuehuo Zeng; Enrique F Schisterman; John F Dou; Kelly M Bakulski; Jason I Feinberg; Munawar Hussain Soomro; Giancarlo Pesce; Nour Baiz; Elena Isaevska; Michelle Plusquin; Marina Vafeiadi; Theano Roumeliotaki; Sabine a S Langie; Arnout Standaert; Catherine Allard; Patrice Perron; Luigi Bouchard; Evelien R van Meel; Janine F Felix; Vincent W V Jaddoe; Paul D Yousefi; Cecilia H Ramlau-Hansen; Caroline L Relton; Elmar W Tobi; Anne P Starling; Ivana V Yang; Maria Llambrich; Gillian Santorelli; Johanna Lepeule; Lucas A Salas; Mariona Bustamante; Susan L Ewart; Hongmei Zhang; Wilfried Karmaus; Stefan Röder; Ana Claudia Zenclussen; Jianping Jin; Wenche Nystad; Christian M Page; Maria Magnus; Dereje D Jima; Cathrine Hoyo; Rachel L Maguire; Tuomas Kvist; Darina Czamara; Katri Räikkönen; Tong Gong; Vilhelmina Ullemar; Sheryl L Rifas-Shiman; Emily Oken; Catarina Almqvist; Robert Karlsson; Jari Lahti; Susan K Murphy; Siri E Håberg; Stephanie London; Gunda Herberth; Hasan Arshad; Jordi Sunyer; Regina Grazuleviciene; Dana Dabelea; Régine P M Steegers-Theunissen; Ellen A Nohr; Thorkild I A Sørensen; Liesbeth Duijts; Marie-France Hivert; Vera Nelen; Maja Popovic; Manolis Kogevinas; Tim S Nawrot; Zdenko Herceg; Isabella Annesi-Maesano; M. Daniele Fallin; Edwina Yeung; Carrie V Breton; Berthold Koletzko; Nina Holland; Joseph L Wiemels; Erik Melén; Gemma C Sharp; Matt J Silver; Faisal I Rezwan; John W Holloway

doi:10.1186/s13148-023-01542-5

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Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

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Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Latha Kadalayil, Md Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P Roy, Olivia Solomon, …

Clinical Epigenetics, Vol.15(1)

11/09/2023

DOI: https://doi.org/10.1186/s13148-023-01542-5

Abstract

PACE

Meta-analysis

Birth season

DNA methylation

Differentially methylated regions (DMR)

Latitude

Background: Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear. Methods: We carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N = 9358) and in children aged 1-11 years (12 cohorts, N = 3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points. Results: We identified associations between birth season and DNAm (False Discovery Rate-adjusted p values < 0.05) at two CpGs at birth (winter-born) and four in the childhood (summer-born) analyses when compared to children born in autumn. Furthermore, we identified twenty-six differentially methylated regions (DMR) at birth (winter-born: 8, spring-born: 15, summer-born: 3) and thirty-two in childhood (winter-born: 12, spring and summer: 10 each) meta-analyses with few overlapping DMRs between the birth seasons or the two time points. The DMRs were associated with genes of known functions in tumorigenesis, psychiatric/neurological disorders, inflammation, or immunity, amongst others. Latitude-stratified meta-analyses [higher (≥ 50°N), lower (< 50°N, northern hemisphere only)] revealed differences in associations between birth season and DNAm by birth latitude. DMR analysis implicated genes with previously reported links to schizophrenia (LAX1), skin disorders (PSORS1C, LTB4R), and airway inflammation including asthma (LTB4R), present only at birth in the higher latitudes (≥ 50°N). Conclusions: In this large epigenome-wide meta-analysis study, we provide evidence for (i) associations between DNAm and season of birth that are unique for the seasons of the year (temporal effect) and (ii) latitude-dependent variations in the seasonal associations (spatial effect). DNAm could play a role in the molecular mechanisms underlying the effect of birth season on adult health outcomes.

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Title: Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Creators - without role: Latha Kadalayil - University of Southampton
Md Zahangir Alam - Southampton General Hospital
Cory Haley White - Merck & Co., Inc., Rahway, NJ, USA
Akram Ghantous - Centre International de Recherche sur le Cancer
Esther Walton - University of Bath
Olena Gruzieva - Karolinska Institutet
Simon Kebede Merid - Centre for Palaeogenetics
Ashish Kumar - Stockholm South General Hospital
Ritu P Roy - UCSF Helen Diller Family Comprehensive Cancer Center
Olivia Solomon - University of California, Berkeley
Karen Huen - University of California, Berkeley
Brenda Eskenazi - University of California, Berkeley
Peter Rzehak - Ludwig-Maximilians-Universität München
Veit Grote - Ludwig-Maximilians-Universität München
Jean-Paul Langhendries - Clinique Saint-Vincent [Liège-Rocourt,Belgium]
Elvira Verduci - Ospedale dei Bambini Vittore Buzzi
Natalia Ferre - Universidad Rovira i Virgili
Darek Gruszfeld
Lu Gao - University of Southern California
Weihua Guan - University of Minnesota
Xuehuo Zeng - Glotech
Enrique F Schisterman - University of Pennsylvania
John F Dou - University of Michigan–Ann Arbor
Kelly M Bakulski - University of Michigan–Ann Arbor
Jason I Feinberg - Johns Hopkins University
Munawar Hussain Soomro - Institut Pierre Louis d‘Épidémiologie et de Santé Publique
Giancarlo Pesce - Inserm
Nour Baiz - Université de Montpellier, Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Elena Isaevska - University of Turin
Michelle Plusquin - Hasselt University
Marina Vafeiadi - University of Crete
Theano Roumeliotaki - University of Crete
Sabine a S Langie - Flemish Institute for Technological Research
Arnout Standaert - Flemish Institute for Technological Research
Catherine Allard - Centre Hospitalier Universitaire de Sherbrooke
Patrice Perron - Université de Sherbrooke
Luigi Bouchard - Université de Sherbrooke
Evelien R van Meel - Erasmus MC
Janine F Felix - Erasmus MC
Vincent W V Jaddoe - Erasmus MC
Paul D Yousefi - Medical Research Council
Cecilia H Ramlau-Hansen - Aarhus University
Caroline L Relton - Medical Research Council
Elmar W Tobi - Erasmus MC
Anne P Starling - University of Colorado Anschutz Medical Campus
Ivana V Yang - Colorado School of Public Health
Maria Llambrich - Barcelona Institute for Global Health
Gillian Santorelli - University of Bradford
Johanna Lepeule - Inserm
Lucas A Salas - Barcelona Institute for Global Health
Mariona Bustamante - Barcelona Institute for Global Health
Susan L Ewart - Michigan State University
Hongmei Zhang - University of Memphis
Wilfried Karmaus - University of Memphis
Stefan Röder - Helmholtz Centre for Environmental Research
Ana Claudia Zenclussen - Helmholtz Centre for Environmental Research
Jianping Jin - Meridian Institute
Wenche Nystad - Norwegian Institute of Public Health
Christian M Page - Norwegian Institute of Public Health
Maria Magnus - Norwegian Institute of Public Health
Dereje D Jima - North Carolina State University
Cathrine Hoyo - North Carolina State University
Rachel L Maguire - North Carolina State University
Tuomas Kvist - University of Helsinki
Darina Czamara - Max Planck Institute of Psychiatry
Katri Räikkönen - University of Helsinki
Tong Gong - Karolinska Institutet
Vilhelmina Ullemar - Karolinska Institutet
Sheryl L Rifas-Shiman - Harvard Pilgrim Health Care
Emily Oken - Harvard Pilgrim Health Care
Catarina Almqvist - Karolinska Institutet
Robert Karlsson - Karolinska Institutet
Jari Lahti - University of Helsinki
Susan K Murphy - Duke Medical Center
Siri E Håberg - Norwegian Institute of Public Health
Stephanie London - National Institute of Environmental Health Sciences
Gunda Herberth - Helmholtz Centre for Environmental Research
Hasan Arshad
Jordi Sunyer - Barcelona Institute for Global Health
Regina Grazuleviciene - Vytautas Magnus University
Dana Dabelea - Colorado School of Public Health
Régine P M Steegers-Theunissen - Erasmus MC
Ellen A Nohr
Thorkild I A Sørensen - University of Copenhagen
Liesbeth Duijts - Erasmus MC
Marie-France Hivert
Vera Nelen - Provincial Institute for Hygiene
Maja Popovic - University of Turin
Manolis Kogevinas
Tim S Nawrot - Hasselt University
Zdenko Herceg - Centre International de Recherche sur le Cancer
Isabella Annesi-Maesano - Inserm
M. Daniele Fallin - Johns Hopkins University
Edwina Yeung - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Carrie V Breton - University of Southern California
Berthold Koletzko - Ludwig-Maximilians-Universität München
Nina Holland - Berkeley Public Health Division
Joseph L Wiemels - University of Southern California
Erik Melén - Sachs' Children and Youth Hospital
Gemma C Sharp - Medical Research Council
Matt J Silver - MRC Unit the Gambia
Faisal I Rezwan - Aberystwyth University
John W Holloway - NIHR Southampton Biomedical Research Centre
Publication Details: Clinical Epigenetics, Vol.15(1)
Identifiers: 9941596709311
Academic Unit: Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Language: English
Resource Type: Journal article
Local Fields: hal-04660902