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An overview of the KIN1/PAR-1/MARK kinase family
Article de revue scientifique   Avec comité de lecture

An overview of the KIN1/PAR-1/MARK kinase family

Jean-Pierre Tassan et Xavier Le Goff
Biology of the cell, Vol.96(3), p.193-199
04/2004
PMID: 15182702

Résumé

Animals Cell Cycle - physiology Cell Division - physiology Humans Phosphoproteins - physiology Protein Kinases - physiology Protein-Serine-Threonine Kinases - classification Protein-Serine-Threonine Kinases - physiology Saccharomyces cerevisiae Proteins - physiology Signal Transduction - physiology Xenopus Proteins - physiology Yeasts
Members of the KIN1/PAR-1/MARK kinase family are conserved from yeast to humans and share a similar primary structural organization. Several kinases of this family appear to be at the crossroads of various biological functions including cell polarity, cell cycle control, intracellular signalisation, microtubules stability and protein stability. Here we present an overview of known roles of KIN1/PAR-1/MARK kinases including pEg3 a newly identified member which is regulated during the cell cycle and is a potential regulator of the cell cycle progression. Some common modes of action can be deciphered for this protein kinase family.

Indicateurs

1 Consultations de la notice

Détails

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