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An application of the Mitsunobu reaction in mannose series, using triethyl methanetricarboxylate as pronucleophile
Journal article   Open access   Peer reviewed

An application of the Mitsunobu reaction in mannose series, using triethyl methanetricarboxylate as pronucleophile

Cătălina Ionescu, Georgeta Ciobanu and Véronique Barragan-Montero
Afinidad. Journal of Chemical Engineering Theoretical and Applied Chemistry, Vol.80(600)
20/12/2023

Abstract

mannose triethyl methanetricarboxylate Mitsunobu reaction mannose triethyl methanetricarboxylate Mitsunobu reaction
Triethyl methanetricarboxylate, HC(CO2 Et) 3 , is a pronucleophile used in order to achieve chain elongation and ramification. In the present paper, it has been coupled to the C6 position of mannose in a one-step synthesis, via the Mitsunobu reaction, in 71% yield. The synthesis provides a direct and rapid route to a product that might be further used to obtain mannose analogues with various functional groups (e. g. carboxylic acids) in C6 position.
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